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Skin Cancer Research

in the peer-reviewed medical literature

None of the 700+ studies listed on this site can substitute for consulting a licensed naturopathic physician.  And none can be expected to function as stand-alone, at-home treatment.

Vitamin C significantly induced cell cycle arrest and apoptosis in Melanoma.


Melanoma Res. 2006 Dec;16(6):509-19.

Sodium ascorbate inhibits growth via the induction of cell cycle arrest and apoptosis in human malignant melanoma A375.S2 cells.

Lin SY1, Lai WWChou CCKuo HMLi TMChung JGYang JH.


Vitamin C deficiency increased growth and spread of melanoma cells in mice deprived of it.


Exp Oncol. 2011 Dec;33(4):226-30.

Ascorbate depletion increases growth and metastasis of melanoma cells in vitamin C deficient mice.

Cha J1, Roomi MW, Ivanov V, Kalinovsky T, Niedzwiecki A, Rath M.



An intravenous nutrient mixture of ascorbic acid, lysine, proline, arginine, and green tea extract have shown to inhibit lung metastasis of some melanoma cells in mice.


Exp Lung Res. 2006 Nov-Dec;32(10):517-30.

Inhibition of pulmonary metastasis of melanoma b16fo cells in C57BL/6 mice by a nutrient mixture consisting of ascorbic Acid, lysine, proline, arginine, and green tea extract.

Roomi MW1, Roomi N, Ivanov V, Kalinovsky T, Niedzwiecki A, Rath M.

Vitamin D compounds may contribute to skin cancer prevention.


Dermatoendocrinol. 2013 Jan 1;5(1):20-33. doi: 10.4161/derm.23939.

Novel vitamin D compounds and skin cancer prevention.

Tongkao-On W1, Gordon-Thomson C1, Dixon KM1, Song EJ1, Luu T1, Carter SE1, Sequeira VB2, Reeve VE3, Mason RS1.


This paper documents the protective effects on UV light-induced skin cancer of Thai plants and their bioactive compounds.


J Photochem Photobiol B2018 May 2;185:80-89. doi: 10.1016/j.jphotobiol.2018.04.046. [Epub ahead of print]

The protective effect of some Thai plants and their bioactive compounds in UV light-induced skin carcinogenesis.

de Silva MBTencomnao T.


Phytochemicals, such as steroids, coumarines, trepenes, essential oils, alkaloids, esters, ethers, resins, phenols and flavonoids are examined  and information is provided about marketed formulations developed so far from plant derived compounds for skin cancer prevention and treatment.


Biomed Pharmacother. 2018 Jul;103:1643-1651. doi: 10.1016/j.biopha.2018.04.113. Epub 2018 May 7.

Plant derived anticancer agents: A green approach towards skin cancers.

Ijaz SAkhtar NKhan MSHameed AIrfan MArshad MAAli SAsrar M.

Viwithan an extract from the roots Rennet (Withania somnifera) is potently toxic to melanoma skin cancer cells.


Pharmacogn Mag.   Sudeep HV, Gouthamchandra K, Venkatesh BJ, Prasad KS. Viwithan, a StandardizedWithania somnifera Root Extract Induces Apoptosis in Murine Melanoma Cells. 2018 Jan;13(Suppl 4):S801-S806. doi: 10.4103/pm.pm_121_17. Epub 2018 Jan 31. PubMed PMID: 29491636; PubMed Central PMCID: PMC5822503.


Leaf and stem extracts from Graviola (Annona muricata) were shown to treat non-melanoma skin cancer.


Int J Mol Sci.  Chamcheu JC, Rady I, Chamcheu RN, Siddique AB, Bloch MB, Banang Mbeumi S, Babatunde AS, Uddin MB, Noubissi FK, Jurutka PW, Liu YY, Spiegelman VS, Whitfield GK, El Sayed KA. Graviola (Annona muricata) Exerts Anti-Proliferative, Anti-Clonogenic and Pro-Apoptotic Effects in Human Non-Melanoma Skin Cancer UW-BCC1 and A431 Cells In Vitro: Involvement of Hedgehog Signaling. 2018 Jun 16;19(6). doi: 10.3390/ijms19061791. PubMed PMID: 29914183; PubMed Central PMCID: PMC6032424.


Extra-virgin olive oil extracts can be used effectively to prevent or treat non-melanoma skin cancer.

Toxicol In Vitro.  Polini B, Digiacomo M, Carpi S, Bertini S, Gado F, Saccomanni G, Macchia M, Nieri P, Manera C, Fogli S. Oleocanthal and oleacein contribute to the in vitro therapeutic potential of extra virgin oil-derived extracts in non-melanoma skin cancer. . 2018 Oct;52:243-250. doi: 10.1016/j.tiv.2018.06.021. Epub 2018 Jun 28. PubMed PMID: 29959992.

​Sutherlandia frutescens extract is effective in inducing apoptosis in malignant melanoma cells.


Evid Based Complement Alternat Med. 2016;2016:4921067. doi: 10.1155/2016/4921067. Epub 2016 Aug 30.

The Induction of Apoptosis in A375 Malignant Melanoma Cells by Sutherlandia frutescens.

van der Walt NB1, Zakeri Z2, Cronjé MJ1.



Bupleurum kaoi shows anti-melanoma activity and may have potential use in the future as a form of treatment for melanoma.


J Ethnopharmacol. 2016 Feb 17;179:432-42. doi: 10.1016/j.jep.2015.12.058. Epub 2015 Dec 31.

Anti-melanoma activity of Bupleurum chinense, Bupleurum kaoi and nanoparticle formulation of their major bioactive compound saikosaponin-d.

Hu SC1, Lee IT2, Yen MH3, Lin CC3, Lee CW4, Yen FL5.

Curcumin has a potential role in the treatment of melanoma.


Biomed Pharmacother. 2017 Apr;88:832-834. doi: 10.1016/j.biopha.2017.01.078. Epub 2017 Feb 24.

Curcumin and treatment of melanoma: The potential role of microRNAs.

Lelli D1, Pedone C1, Sahebkar A2.


Curcumin may provide a valuable tool for the development of a therapeutic combination against melanoma.


Int J Cancer. 2004 Sep 1;111(3):381-7.

In vitro and in vivo anti-tumoral effect of curcumin against melanoma cells.

Odot J1, Albert PCarlier ATarpin MDevy JMadoulet C.



Garlic appears to be a good candidate as an antitumor agent against melanoma.


Immunopharmacol Immunotoxicol. 2010 Sep;32(3):371-5. doi: 10.3109/08923970903420574.

Cytotoxic effect of garlic extract and its fractions on Sk-mel3 melanoma cell line.

Hakimzadeh H1, Ghazanfari TRahmati BNaderimanesh H.


S-allyl cysteine inhibited cellular growth and proliferation and modulated major cell differentiation markers of melanoma.


Oncology. 1993;50(1):63-9.

Growth inhibition and modulation of cell markers of melanoma by S-allyl cysteine.

Takeyama H1, Hoon DSSaxton REMorton DLIrie RF.



A nutrient mixture of ascorbic acid, lysine, proline, arginine, and green tea extract is effective in inhibiting the metastasis of melanoma cells.


Exp Lung Res. 2006 Nov-Dec;32(10):517-30.

Inhibition of pulmonary metastasis of melanoma b16fo cells in C57BL/6 mice by a nutrient mixture consisting of ascorbic Acid, lysine, proline, arginine, and green tea extract.

Roomi MW1, Roomi NIvanov VKalinovsky TNiedzwiecki ARath M.



Selenium might be a potent inhibitor of the metastatic capacity of melanoma cells.


Int Immunopharmacol. 2011 Dec;11(12):2208-13. doi: 10.1016/j.intimp.2011.10.002. Epub 2011 Oct 18.

Selenium inhibits migration of murine melanoma cells via down-modulation of IL-18 expression.

Song H1, Kim JLee HKPark HJNam JPark GBKim YSCho DHur DY.



Quercetin and Sulforaphane may be an effective approach for the treatment of malignant melanoma.


Exp Ther Med. 2010 Nov;1(6):915-920. Epub 2010 Aug 26.

Quercetin and sulforaphane in combination suppress the progression of melanoma through the down-regulation of matrix metalloproteinase-9.

Pradhan SJ1, Mishra RSharma PKundu GC.


Quercetin may have a potential role in the prevention and treatment of melanoma.


Biochem Pharmacol. 2014 Feb 1;87(3):424-34. doi: 10.1016/j.bcp.2013.11.008. Epub 2013 Nov 23.

Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling.

Cao HH1, Tse AK1, Kwan HY1, Yu H1, Cheng CY1, Su T1, Fong WF1, Yu ZL2.



In this study, zinc induces apoptosis in melanoma cells.


Anticancer Res. 2015 Oct;35(10):5309-16.

Zinc Induces Apoptosis of Human Melanoma Cells, Increasing Reactive Oxygen Species, p53 and FAS Ligand.

Provinciali M1, Pierpaoli E2, Bartozzi B2, Bernardini G2.



Benzyl isothiocyanates has potential as an agent for the treatment of melanoma.


J Agric Food Chem. 2012 Jan 18;60(2):665-75. doi: 10.1021/jf204193v. Epub 2012 Jan 6.

Benzyl isothiocyanate (BITC) induces G2/M phase arrest and apoptosis in human melanoma A375.S2 cells through reactive oxygen species (ROS) and both mitochondria-dependent and death receptor-mediated multiple signaling pathways.

Huang SH1, Wu LWHuang ACYu CCLien JCHuang YPYang JSYang JHHsiao YPWood WGYu CSChung JG.



Phenethyl Isothiocyanate triggered apoptotic death in A375.S2 cells.


Hum Exp Toxicol. 2014 Mar;33(3):270-83. doi: 10.1177/0960327113491508. Epub 2013 Jun 11.

Phenethyl isothiocyanate triggers apoptosis in human malignant melanoma A375.S2 cells

through reactive oxygen species and the mitochondria-dependent pathways.

Huang SH1, Hsu MHHsu SCYang JSHuang WWHuang ACHsiao YPYu CCChung JG.


Cantharidin may have potential as a novel anti-cancer agent for the treatment of skin cancer.


Int J Oncol. 2014 Dec;45(6):2393-402. doi: 10.3892/ijo.2014.2689. Epub 2014 Sep 30.

Cantharidin induces G2/M phase arrest by inhibition of Cdc25c and Cyclin A and triggers apoptosis through reactive oxygen species and the mitochondria‑dependent pathways of A375.S2 human melanoma cells.

Hsiao YP1, Tsai CH1, Wu PP2, Hsu SC3, Liu HC3, Huang YP4, Yang JH5, Chung JG3.



Casticin, found in the plant Artemisia annua, could be used as an inhibitor of migration and invasion of human melanoma cells.


Molecules. 2016 Mar 19;21(3):384. doi: 10.3390/molecules21030384.

Casticin Inhibits A375.S2 Human Melanoma Cell Migration/Invasion through Downregulating NF-κB and Matrix Metalloproteinase-2 and -1.

Wu ZY1, Lien JC2, Huang YP3, Liao CL4, Lin JJ5, Fan MJ6, Ko YC7, Hsiao YP8, Lu HF9,10, Chung JG11,12.



Gallic acid may be potential cancer chemotherapeutic agent, which can markedly inhibit the invasive capacity of melanoma cells.


Melanoma Res. 2011 Aug;21(4):267-73. doi: 10.1097/CMR.0b013e3283414444.

Gallic acid inhibits the migration and invasion of A375.S2 human melanoma cells through the inhibition of matrix metalloproteinase-2 and Ras.

Lo C1, Lai TYYang JSYang JHMa YSWeng SWLin HYChen HYLin JGChung JG.



This study shows that Milk Thistle extract (Silybin) suppresses melanoma growth.


Cancer Prev Res (Phila). 2013 May;6(5):455-65. doi: 10.1158/1940-6207.CAPR-12-0425. Epub 2013 Feb 27.

Direct targeting of MEK1/2 and RSK2 by silybin induces cell-cycle arrest and inhibits melanoma cell growth.

Lee MH1, Huang ZKim DJKim SHKim MOLee SYXie HPark SJKim JYKundu JKBode AMSurh YJDong Z.



Remirea maritima is antioxidant and anti-proliferative against melanoma cells.


Molecules. 2015 Jun 25;20(7):11699-718. doi: 10.3390/molecules200711699.

Redox-Active Profile Characterization of Remirea maritima Extracts and Its Cytotoxic Effect in Mouse Fibroblasts (L929) and Melanoma (B16F10) Cells.

Dória GA1, Santos AR2, Bittencourt LS3, Bortolin RC4, Menezes PP5, Vasconcelos BS6, Souza RO7, Fonseca MJ8, Santos AD9, Saravanan S10, Silva FA11, Gelain DP12, Moreira JC13, Prata AP14, Quintans-Júnior LJ15, Araújo AA16.



Crude water extract of Withania somnifera has potent cytotoxic effect on human malignant melanoma A375 cells.


PLoS One. 2015 Sep 3;10(9):e0137498. doi: 10.1371/journal.pone.0137498. eCollection 2015.

Withania somnifera Root Extract Has Potent Cytotoxic Effect against Human Malignant Melanoma Cells.

Halder B1, Singh S1, Thakur SS1.



The plant Rubus inhibits human melanoma cell growth.


Biomed Pharmacother. 2016 May;80:193-9. doi: 10.1016/j.biopha.2016.03.022. Epub 2016 Mar 26.

Caspase dependent apoptotic inhibition of melanoma and lung cancer cells by tropical Rubus extracts.

George BP1, Abrahamse H2, Hemmaragala NM2.


Garcinia hanburyi extract can inhibit the proliferation of malignant melanoma cells and induce their apoptosis.


Int J Dermatol. 2009 Feb;48(2):186-92. doi: 10.1111/j.1365-4632.2009.03946.x.

Gambogic acid induces apoptosis by regulating the expression of Bax and Bcl-2 and enhancing caspase-3 activity in human malignant melanoma A375 cells.

Xu X1, Liu YWang LHe JZhang HChen XLi YYang JTao J.



Rhodiola crenulata extract may harbor potential novel adjuvant therapy for the treatment of melanoma.


Tumour Biol. 2015 Dec;36(12):9795-805. doi: 10.1007/s13277-015-3742-2. Epub 2015 Jul 10.

Antineoplastic effects of Rhodiola crenulata treatment on B16-F10 melanoma.

Dudek MC1,2, Wong KE1,2,3, Bassa LM1,2, Mora MC2,3, Ser-Dolansky J1, Henneberry JM3, Crisi GM3, Arenas RB3, Schneider SS4,5,6,7.


Water extract of Inonotus obliquus mushroom exhibited a potential anticancer activity against melanoma cells.


J Ethnopharmacol. 2009 Jan 21;121(2):221-8. doi: 10.1016/j.jep.2008.10.016. Epub 2008 Oct 25.

Potential anticancer properties of the water extract of Inonotus [corrected] obliquus by induction of apoptosis in melanoma B16-F10 cells.

Youn MJ1, Kim JKPark SYKim YPark CKim ESPark KISo HSPark R.


Curcuma rhizome may be a promising natural source for active compounds against malignant melanoma.


Biol Res. 2015 Jan 12;48:1. doi: 10.1186/0717-6287-48-1.

Evaluation of phenolic profile, antioxidant and anticancer potential of two main representants of Zingiberaceae family against B164A5 murine melanoma cells.

Danciu C1, Vlaia L2, Fetea F3, Hancianu M4, Coricovac DE5, Ciurlea SA6, Şoica CM7, Marincu I8, Vlaia V9, Dehelean CA10, Trandafirescu C11.


Aqueous extract of Vietnamese Sophora Root can inhibit the proliferation of melanoma cells


Afr J Tradit Complement Altern Med. 2013 Nov 2;11(1):62-6. eCollection 2014.

Effects of Vietnamese Sophora Root on growth, adhesion, invasion and motility of melanoma cells.

Zhang D1, Liu S1, Yao M1, Liu X1, Lai H1.


Compounds found in the plant Sophora genu, inhibit the invasiveness and metastasis of human malignant melanoma cells.


Int J Dermatol. 2008 May;47(5):448-56. doi: 10.1111/j.1365-4632.2008.03627.x.

Matrine inhibits invasiveness and metastasis of human malignant melanoma cell line A375 in vitro.

Liu XY1, Fang HYang ZGWang XYRuan LMFang DRDing YGWang YNZhang YJiang XLChen HC.


Extract from the dried rhizomes of Curcuma comosa is a promising therapeutic agent for skin disorders such as melanoma.


Bioorg Med Chem Lett. 2013 Sep 15;23(18):5178-81. doi: 10.1016/j.bmcl.2013.07.010. Epub 2013 Jul 17.

Diarylheptanoids with inhibitory effects on melanogenesis from the rhizomes of Curcuma comosa in B16 melanoma cells.

Matsumoto T1, Nakamura SNakashima SYoshikawa MFujimoto KOhta TMorita AYasui RKashiwazaki EMatsuda H.



Sanguinarine, An ammonium salt found in the bloodroot plant, is a rapid inducer of human melanoma caspase-dependent cell death.


Eur J Pharmacol. 2013 Apr 5;705(1-3):109-18. doi: 10.1016/j.ejphar.2013.02.035. Epub 2013 Mar 13.

Rapid human melanoma cell death induced by sanguinarine through oxidative stress.

Burgeiro A1, Bento ACGajate COliveira PJMollinedo F.



In this study, Eruca sativa extract, reduced tumor growth and inhibited melanoma growth.


Fitoterapia. 2011 Jun;82(4):647-53. doi: 10.1016/j.fitote.2011.02.004. Epub 2011 Feb 21.

Phytochemical potential of Eruca sativa for inhibition of melanoma tumor growth.

Khoobchandani M1, Ganesh NGabbanini SValgimigli LSrivastava MM.



Hibiscus rosa-sinesis flower extract contains compounds that inhibit melanoma cell growth.


J Tradit Complement Med. 2016 Feb 23;7(1):45-49. doi: 10.1016/j.jtcme.2016.01.005. eCollection 2017.

Components in aqueous Hibiscus rosa-sinensis flower extract inhibit in vitro melanoma cell growth.

Goldberg KH1, Yin AC2, Mupparapu A2, Retzbach EP2, Goldberg GS2, Yang CF1.


Taraxacum coreanum , Youngia sonchifolia, and Ixeris dentata plant extracts suppress the growth of human melanoma cells through apoptosis.


J Ethnopharmacol. 2016 Dec 24;194:1022-1031. doi: 10.1016/j.jep.2016.11.010. Epub 2016 Nov 8.

Anticancer effects of Ixeris dentata (Thunb. ex Thunb.) nakai extract on human melanoma cells A375P and A375SM.

Lee HN1, Shin SA1, Choo GS1, Kim HJ1, Park YS1, Park BK1, Kim BS1, Kim SK1, Cho SD2, Nam JS3, Choi CS4, Jung JY5.

Ruta graveolen extract induces both apoptotic and autophagic cell death in skin melanoma cells

Phytother Res. 2014 Aug;28(8):1153-62. doi: 10.1002/ptr.5107. Epub 2013 Dec 17.

Graveoline isolated from ethanolic extract of Ruta graveolens triggers apoptosis and autophagy in skin melanoma cells: a novel apoptosis-independent autophagic signaling pathway.

Ghosh S1, Bishayee KKhuda-Bukhsh AR.



Huaier ( the extract from the fungus Trametes robiniophila Murriell) is an effective complementary agent for cancer treatment of melanoma.


Acta Histochem. 2013 Sep;115(7):705-11. doi: 10.1016/j.acthis.2013.02.010. Epub 2013 Apr 16.

Effects of Huaier aqueous extract on proliferation and apoptosis in the melanoma cell line A875.

Zhang F1, Zhang ZLiu Z.



Germinated brown rice fraction can act as an effective anticancer agent to treat melanoma.


Evid Based Complement Alternat Med. 2013;2013:321096. doi: 10.1155/2013/321096. Epub 2013 Feb 25.

Antrodia camphorata Grown on Germinated Brown Rice Suppresses Melanoma Cell Proliferation by Inducing Apoptosis and Cell Differentiation and Tumor Growth.

Song M1, Park DKPark HJ



St John's-wort perforatum-derived product was able to suppress proliferation of human malignant melanoma cells.


Cell Prolif. 2013 Apr;46(2):193-202. doi: 10.1111/cpr.12020.

Hypericum perforatum L. subsp. perforatum induces inhibition of free radicals and enhanced phototoxicity in human melanoma cells under ultraviolet light.

Menichini G1, Alfano CMarrelli MToniolo CProvenzano EStatti GANicoletti MMenichini FConforti F.



Sinularia may be helpful for drug development and progression monitoring of human melanoma.


Electrophoresis. 2012 Apr;33(7):1139-52. doi: 10.1002/elps.201100462.

Proteomic investigation of anti-tumor activities exerted by sinularin against A2058 melanoma cells.

Su TR1, Lin JJChiu CCChen JYSu JHCheng ZJHwang WIHuang HHWu YJ.



Labisia pumila extract was able to inhibit human melanoma cell growth.


Evid Based Complement Alternat Med. 2012;2012:123470. doi: 10.1155/2012/123470. Epub 2012 Mar 8.

Antiproliferative and Proapoptotic Effects of Labisia pumila Ethanol Extract and Its Active Fraction in Human Melanoma HM3KO Cells.

Lope Pihie AH1, Zakaria ZAOthman F.



Ume apricot extract is a potential therapeutic agent for treating malignant melanoma.


Phytother Res. 2012 Jun;26(6):833-8. doi: 10.1002/ptr.3645. Epub 2011 Nov 10.

MK615, a Prunus mume Steb. Et Zucc ('Ume') extract, attenuates the growth of A375 melanoma cells by inhibiting the ERK1/2-Id-1 pathway.

Tada K1, Kawahara KMatsushita SHashiguchi TMaruyama IKanekura T.



Zyflamend inhibits melanoma growth by regulating the autophagy-apoptosis.


Nutr Cancer. 2011;63(6):940-9. doi: 10.1080/01635581.2011.586488. Epub 2011 Jul 11.

Zyflamend mediates therapeutic induction of autophagy to apoptosis in melanoma cells.

Ekmekcioglu S1, Chattopadhyay CAkar UGabisi A JrNewman RAGrimm EA.



Grape seed compounds  have the ability to inhibit melanoma cell invasion/migration.


PLoS One. 2011;6(6):e21539. doi: 10.1371/journal.pone.0021539. Epub 2011 Jun 27.

Grape seed proanthocyanidins inhibit melanoma cell invasiveness by reduction of PGE2 synthesis and reversal of epithelial-to-mesenchymal transition.

Vaid M1, Singh TKatiyar SK.



The plant Dioscorea nipponica could reduce the metastasis of melanoma cells.


Evid Based Complement Alternat Med. 2011;2011:507920. doi: 10.1155/2011/507920. Epub 2011 Jan 10.

Antimetastatic Potentials of Dioscorea nipponica on Melanoma In Vitro and In Vivo.

Ho ML1, Hsieh YSChen JYChen KSChen JJKuo WHLin SJChen PN.



Black nightshade has potential application for treating metastatic melanoma.


J Agric Food Chem. 2010 Nov 24;58(22):11913-23. doi: 10.1021/jf1022065. Epub 2010 Oct 28.

Solanum nigrum Linn. water extract inhibits metastasis in mouse melanoma cells in vitro and in vivo.

Wang HC1, Wu DHChang YCLi YJWang CJ.


Panax ginseng extract cell proliferation through inducing apoptosis.


J Ethnopharmacol. 2010 Oct 28;132(1):115-21. doi: 10.1016/j.jep.2010.07.052. Epub 2010 Aug 5.

The ethyl acetate extract of PGP (Phellinus linteus grown on Panax ginseng) suppresses B16F10 melanoma cell proliferation through inducing cellular differentiation and apoptosis.

Park HJ1, Han ESPark DK.



The extract of the plant Lang-du  may have a wide therapeutic and/or adjuvant therapeutic application in the treatment of melanoma.


Cytotechnology. 2010 Aug;62(4):357-66. doi: 10.1007/s10616-010-9283-z. Epub 2010 Jul 4.

Inhibitory effects of Lang-du extract on the in vitro and in vivo growth of melanoma cells and its molecular mechanisms of action.

Wang L1, Duan HWang YLiu KJiang PQu ZYagasaki KZhang G.



Euphorbia fischeriana Steud may have broad therapeutic applications in the treatment of malignant melanoma.


Exp Ther Med. 2016 Apr;11(4):1475-1480. Epub 2016 Feb 9.

Euphorbia fischeriana Steud inhibits malignant melanoma via modulation of the phosphoinositide-3-kinase/Akt signaling pathway.

Dong MH1, Zhang Q1, Wang YY2, Zhou BS3, Sun YF1, Fu Q1.



Red spider lily extract exhibits anti-cancer activity against melanoma cells.


Oncol Rep. 2010 Aug;24(2):473-8.

Ethanol extract of Lycoris radiata induces cell death in B16F10 melanoma via p38-mediated AP-1 activation.

Son M1, Kim ALee JPark CHHeo JCLee HJLee SH.



Apigenin and Luteolin (Compounds found in certain plants) inhibit cell growth in both amelanotic melanoma and malignant melanoma cells.


Z Naturforsch C. 2010 Mar-Apr;65(3-4):180-6.

In vitro antioxidant and antiproliferative activities of flavonoids from Ailanthus excelsa (Roxb.) (Simaroubaceae) leaves.

Said A1, Tundis RHawas UWEl-Kousy SMRashed KMenichini FBonesi MHuefner ALoizzo MRMenichinib F.



The plant Phlebodium aureum may be beneficial for skin cancer prevention or treatment.


Arch Dermatol Res. 2009 Aug;301(7):487-95. doi: 10.1007/s00403-009-0950-x. Epub 2009 Apr 17.

Beneficial regulation of matrixmetalloproteinases and their inhibitors, fibrillar collagens and transforming growth factor-beta by Polypodium leucotomos, directly or in dermal fibroblasts, ultraviolet radiated fibroblasts, and melanoma cells.

Philips N1, Conte JChen YJNatrajan PTaw MKeller TGivant JTuason MDulaj LLeonardi DGonzalez S.


The plant Boerhaavia diffusa could enhance the immune response against metastatic progression of melanoma cells.


J Exp Ther Oncol. 2008;7(1):17-29.

Boerhaavia diffusa stimulates cell-mediated immune response by upregulating IL-2 and downregulating the pro-inflammatory cytokines and GM-CSF in B16F-10 metastatic melanoma bearing mice.

Manu KA1, Kuttan G.



Celastrus orbiculatus extract has cytotoxic activity against human melanoma cells.


J Ethnopharmacol. 2008 Apr 17;117(1):175-7. doi: 10.1016/j.jep.2008.01.028. Epub 2008 Feb 6.

Cytotoxic sesquiterpenoids from the ethanol extract of fruits of Celastrus orbiculatus.

Xu J1, Guo YQLi XWei KZhao XJ.



In this study, the plant Biophytum sensitivum, showed inhibitory effects melanoma cells.


J Exp Ther Oncol. 2007;6(3):241-50.

Anti-angiogenic effect of Biophytum sensitivum is exerted through its cytokine modulation activity and inhibitory activity against VEGF mRNA expression, endothelial cell migration and capillary tube formation.

Guruvayoorappan C1, Kuttan G.



A mixture of Ascorbic Acid, Lysine, Proline and Green Tea Extract may have a therapeutic potential in melanoma.


In Vivo. 2006 Jan-Feb;20(1):25-32.

In vivo and in vitro antitumor effect of ascorbic acid, lysine, proline and green tea extract on human melanoma cell line A2058.

Roomi MW1, Ivanov VNetke SKalinovsky TNiedzwiecki ARath M.


Adzuki bean extract inhibits the adhesion and migration of melanoma cells.


Biosci Biotechnol Biochem. 2005 Mar;69(3):448-54.

Potential ability of hot water adzuki (Vigna angularis) extracts to inhibit the adhesion, invasion, and metastasis of murine B16 melanoma cells.

Itoh T1, Umekawa HFuruichi Y.

Sho-saiko-to could suppress the proliferation of carcinoma cells.


Cancer Res. 1994 Jan 15;54(2):448-54.

The herbal medicine sho-saiko-to inhibits proliferation of cancer cell lines by inducing apoptosis and arrest at the G0/G1 phase.

Yano H1, Mizoguchi AFukuda KHaramaki MOgasawara SMomosaki SKojiro M.

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