Gastric and Esophageal Cancer Research
in the peer-reviewed medical literature
None of the 700+ studies listed on this site can substitute for consulting a licensed naturopathic physician. And none can be expected to function as stand-alone, at-home treatment.
High-dose vitamin C decreased esophageal cancer tumors in rats.
Acta Cir Bras. 2009 May-Jun;24(3):183-8.
Role of the vitamin C in diethylnitrosamine-induced esophageal cancer in Wistar rats.
Curcumin may be considered a novel therapeutic strategy to inhibit gastric cancer cell growth.
Oncol Lett. 2016 Dec;12(6):5156-5162. doi: 10.3892/ol.2016.5354. Epub 2016 Nov 4.
Curcumin suppresses the proliferation of gastric cancer cells by downregulating H19.
Higher intake of dietary vitamin C might have a protective effect against esophageal cancer.
Int J Cancer. 2016 Apr 15;138(8):1843-50. doi: 10.1002/ijc.29838. Epub 2015 Oct 15.
Association between dietary vitamin C intake and risk of esophageal cancer: A dose-response meta-analysis.
Weikang Keli once a day for 25 days could significantly reduce gastric tumor volumes by about 50%.
Phytomedicine. 2013 Jan 15;20(2):159-65. doi: 10.1016/j.phymed.2012.10.001. Epub 2012 Nov 8.
Chinese medicine formula "Weikang Keli" induces autophagic cell death on human gastric cancer cell line SGC-7901.
Lysine may be a potential therapeutic tool for gastric cancer management.
Am J Cancer Res. 2014 Dec 15;5(1):87-100. eCollection 2015.
KDM5B is overexpressed in gastric cancer and is required for gastric cancer cell proliferation and metastasis.
Vitamins can significantly reduce the risk of gastric cancer, especially vitamin A, vitamin C, vitamin E.
PLoS One. 2014 Dec 30;9(12):e116060. doi: 10.1371/journal.pone.0116060. eCollection 2014.
Vitamin intake reduce the risk of gastric cancer: meta-analysis and systematic review of randomized and observational studies.
Weichang'an Decoction slows tumor growth and metastasis of gastric cancer.
Zhong Xi Yi Jie He Xue Bao. 2005 Sep;3(5):378-81.
[Growth-inhibiting and anti-metastasis effects of Weichang'an Decoction on orthotopic transplant nude mouse model of human gastric cancer].
[Article in Chinese]
Aster tataricus induces apoptosis of gastric cancer cells.
Int J Biol Macromol. 2012 Nov;51(4):509-13. doi: 10.1016/j.ijbiomac.2012.06.019. Epub 2012 Jun 19.
Inhibition of human gastric carcinoma cell growth in vitro by a polysaccharide from Astertataricus.
Nitrate is a well-studied gastric carcinogen. Vitamin C / ascorbic acid reduced carcinogenic nitrates to nitrites.
Ann N Y Acad Sci. 1975 Sep 30;258:181-9.
Reduction of gastric carcinogens with ascorbic acid.
Celastrus orbiculatus not only has significant antiproliferative effects but also has both in vivo and in vitro apoptotic effects in Gastric Cancer.
J Ethnopharmacol. 2017 May 2. pii: S0378-8741(17)30727-4. doi: 10.1016/j.jep.2017.04.030. [Epub ahead of print]
Anticancer efficacy of the ethyl acetate extract from the traditional Chinese medicine herb Celastrus orbiculatus against human gastric cancer.
Flavone Polyphenols inhibited cell proliferation and induced cell death in Gastric Adenocarcinoma.
J Chromatogr B Analyt Technol Biomed Life Sci. 2017 May 15;1053:1-8. doi: 10.1016/j.jchromb.2017.03.035. Epub 2017 Mar 31.
Flavone polyphenols dominate in Thymus schimperi Ronniger: LC-ESI-MS/MS characterization and study of anti-proliferative effects of plant extract on AGS and HepG2 cancer cells.
Rosmarinus officinalis represents a promising anticancer agent against gastric cancer.
Phytomedicine. 2016 Dec 1;23(13):1671-1679. doi: 10.1016/j.phymed.2016.09.008. Epub 2016 Sep 24.
Sageone, a diterpene from Rosmarinus officinalis, synergizes with cisplatin cytotoxicity in SNU-1 human gastric cancer cells.
The present study demonstrated that Urtica dioica inhibited proliferation of gastric and colorectal cancer cells while posing no significant toxic effect on normal cells.
Cell Mol Biol 2016 Oct 15;62(9):90-96.
Cytotoxic effects of Urtica dioica radix on human colon (HT29) and gastric (MKN45) cancer cells mediated through oxidative and apoptotic mechanisms.
Astragalus extract enhances apoptosis in gastric cancer cells in vitro and in vivo.
Pak J Pharm Sci. 2016 Sep;29(5):1473-1482.
Astragalus extract inhibits proliferation but enhances apoptosis in gastric cancer.
Novel polysaccharide from algae extract induces cancer cell apoptosis and arrested cell cycle in gastric cancer cells.
Int J Oncol. 2016 Oct;49(4):1561-1568. doi: 10.3892/ijo.2016.3658. Epub 2016 Aug 18.
A novel polysaccharide derived from algae extract induces apoptosis and cell cycle arrest in human gastric carcinoma MKN45 cells via ROS/JNK signaling pathway.
Scutellaria barbata can inhibit the proliferation and promote apoptosis of human gastric adenocarcinoma cells.
J Pharmacopuncture. 2016 Jun;19(2):129-36. doi: 10.3831/KPI.2016.19.014.
Inductions of Caspase-, MAPK- and ROS-dependent Apoptosis and Chemotherapeutic Effects Caused by an Ethanol Extract of Scutellaria barbata D. Don in Human Gastric Adenocarcinom Cells.
Bornyl acetate, from the plant Blumea balsamifera, potentiates anticancer activity in human gastric cancer cells by inducing apoptosis.
J BUON. 2016 Jan-Feb;21(1):108-17.
Synergistic enhancement of the antitumor activity of 5-fluorouracil by bornyl acetate in SGC-7901 human gastric cancer cells and the determination of the underlying mechanism of action.
In this study, Euphorbia esula extract inhibited proliferation and induced apoptosis in human gastric carcinoma.
World J Gastroenterol. 2016 Apr 7;22(13):3564-72. doi: 10.3748/wjg.v22.i13.3564.
Apoptosis of human gastric carcinoma cells induced by Euphorbia esula latex.
Huaier fungus inhibits tumorigenic capacity of human gastric cancer cells.
J Ethnopharmacol. 2016 Jun 20;186:143-50. doi: 10.1016/j.jep.2016.03.069. Epub 2016 Apr 1.
Huaier aqueous extract sensitizes cells to rapamycin and cisplatin through activating mTOR signaling.
Black currant extract may be a promising anticancer candidate for gastric cancer.
J Med Food. 2016 Apr;19(4):365-73. doi: 10.1089/jmf.2015.3521. Epub 2016 Mar 23.
Black Currant (Ribes nigrum L.) Extract Induces Apoptosis of MKN-45 and TE-1 Cells Through MAPK- and PI3K/Akt-Mediated Mitochondrial Pathways.
Ginkgo biloba extract could inhibit gastric cancer proliferation through adjusting cell cycle and inducing cell apoptosis.
Int J Clin Exp Med. 2015 Nov 15;8(11):20977-82. eCollection 2015.
Ginkgo biloba extract induce cell apoptosis and G0/G1 cycle arrest in gastric cancer cells.
The caper plant inhibits proliferation, and apoptosis was induced in gastric cancer cells.
Exp Ther Med. 2015 Dec;10(6):2403-2409. Epub 2015 Sep 25.
In vitro analysis of the role of the mitochondrial apoptosis pathway in CSBE therapy against human gastric cancer.
Dictamnus extract induces apoptosis of AGS human gastric adenocarcinoma cells.
Pharmacogn Mag. 2015 Oct;11(Suppl 2):S329-36. doi: 10.4103/0973-1296.165994.
Apoptosis of AGS human gastric adenocarcinoma cells by methanolic extract of Dictamnus.
Ethanolic extract of Tulipa edulis bak may inhibit the growth of human gastric cancer by causing apoptosis in the cancer cells.
Oncol Lett. 2015 Oct;10(4):2371-2377. Epub 2015 Jul 16.
Ethanolic extract of Tulipa edulis Bak induces apoptosis in SGC-7901 human gastric carcinoma cells via the mitochondrial signaling pathway.
Ginkgo biloba extract conferred an inhibitory effect on the proliferation of gastric carcinoma cells.
Clin Transl Oncol. 2016 May;18(5):521-6. doi: 10.1007/s12094-015-1399-3. Epub 2015 Oct 21.
The effect of EGB on proliferation of gastric carcinoma SGC7901 cells.
In this study, supercritical fluid extract of Phalsak induced apoptosis with inhibition of human gastric cancer cells.
Evid Based Complement Alternat Med. 2015;2015:402385. doi: 10.1155/2015/402385. Epub 2015 Aug 13.
Auraptene, a Major Compound of Supercritical Fluid Extract of Phalsak (Citrus Hassaku Hort ex Tanaka), Induces Apoptosis through the Suppression of mTOR Pathways in Human Gastric Cancer SNU-1 Cells.
This study revealed the cytotoxic effect of the aqueous extract of Agrostemma githago seed on gastric cancer cells.
J Ethnopharmacol. 2015 Dec 4;175:295-300. doi: 10.1016/j.jep.2015.07.010. Epub 2015 Jul 18.
Aqueous extract of Agrostemma githago seed inhibits caspase-3 and induces cell-cycle arrest at G1 phase in AGS cell line.
Eucommia ulmoides oliver extract exhibited potential anti-tumor activity for AGS gastric cancer cell.
J Food Sci Technol. 2015 Aug;52(8):4925-34. doi: 10.1007/s13197-014-1571-8. Epub 2014 Sep 30.
Microwave-assisted extraction and purification of chlorogenic acid from by-products of Eucommia Ulmoides Oliver and its potential anti-tumor activity.
Cordyceps taii has potent in vivo antitumor and antimetastatic activities in gastric cancer cells.
BMC Complement Altern Med. 2015 Jul 9;15:216. doi: 10.1186/s12906-015-0762-9.
Antitumor and antimetastatic activities of chloroform extract of medicinal mushroom Cordyceps taii in mouse models.
Rheum undulatum mediates cell death associated with an intrinsic apoptotic pathway in human adenocarcinoma gastric cell lines.
J Pharmacopuncture. 2015 Jun;18(2):26-32. doi: 10.3831/KPI.2015.18.012.
Association of a Methanol Extract of Rheum undulatum L. Mediated Cell Death in AGS Cells with an Intrinsic Apoptotic Pathway.
Alocasia cucullate compounds may be a potential source of novel compounds for gastric cancer treatment.
BMC Complement Altern Med. 2015 Feb 26;15:33. doi: 10.1186/s12906-015-0554-2.
Antitumor effect and apoptosis induction of Alocasia cucullata (Lour.) G. Don in human gastric cancer cells in vitro and in vivo.
Extract of Zuojin Pill can potentially serve as an antitumor agent.
Chin J Integr Med. 2015 Nov;21(11):837-45. doi: 10.1007/s11655-015-2043-3. Epub 2015 Apr 6.
Extract of Zuojin Pill ([characters: see text]) induces apoptosis of SGC-7901 cells via mitochondria-dependent pathway.
Celastrus orbiculatus may be considered a novel anticancer agent for the treatment of metastasis in gastric cancer.
Integr Cancer Ther. 2015 May;14(3):271-81. doi: 10.1177/1534735415572880. Epub 2015 Feb 26.
Antimetastatic effects of Celastrus orbiculatus on human gastric adenocarcinoma by inhibiting epithelial-mesenchymal transition and NF-κB/snail signaling pathway.
Extract of Silybum marianum inhibits ADA activity in cancerous gastric tissues significantly.
Pharmacogn Mag. 2015 Jan-Mar;11(41):143-6. doi: 10.4103/0973-1296.149729.
Effects of aqueous extract from Silybum marianum on adenosine deaminase activity in cancerous and noncancerous human gastric and colon tissues.
Prunella vulgaris fungus extract exhibits a growth-suppressive activity on gastric cancer.
Oncol Lett. 2015 Feb;9(2):945-949. Epub 2014 Nov 20.
Extracts of endophytic fungus xkc-s03 from Prunella vulgaris L. spica inhibit gastric cancer in vitro and in vivo.
Ferulago has cytotoxic and apoptosis-inducing effects on gastric cancer cell lines.
Iran J Pharm Res. 2014 Fall;13(4):1335-45.
Anti-tumor Activity of Ferulago angulata Boiss. Extract in Gastric Cancer Cell Line via Induction of Apoptosis.
Ethanol extract of Radix glycyrrhizae has an anti-proliferative activity on human gastric cancer cells.
Afr J Tradit Complement Altern Med. 2014 Jan 28;11(2):334-8. eCollection 2014.
Studies on the identification of constituents in ethanol extract of Radix Glycyrrhizae and their anticancer activity.
Celastrus orbiculatus may be considered a novel anti-cancer agent for the treatment of metastasis in gastric cancer.
BMC Complement Altern Med. 2014 Nov 5;14:433. doi: 10.1186/1472-6882-14-433.
Research on the efficacy of Celastrus Orbiculatus in suppressing TGF-β1-induced epithelial-mesenchymal transition by inhibiting HSP27 and TNF-α-induced NF-κ B/Snail signaling pathway in human gastric adenocarcinoma.
Aqueous extract of Alpinia galangal has anti-proliferative effect on human gastric cancer.
Iran J Cancer Prev. 2014 Summer;7(3):142-6.
The Effects of Aqueous Extract of Alpinia Galangal on Gastric Cancer Cells (AGS) and L929 Cells in Vitro.
Schizandra chinensis extracts might be an effective chemotherapeutic for the treatment of human gastric cancer.
Pharm Biol. 2015 Feb;53(2):212-9. doi: 10.3109/13880209.2014.913297. Epub 2014 Sep 22.
Schizandra chinensis extracts induce apoptosis in human gastric cancer cells via JNK/p38 MAPK activation and the ROS-mediated/mitochondria-dependent pathway.
Actinidia valvata dunn extract exhibits an obvious preventive effect on gastrointestinal carcinogenesis through the regulation of cell proliferation and apoptosis.
Asian Pac J Cancer Prev. 2014;15(15):6363-7.
Preventive effect of Actinidia valvata Dunn extract on N-methyl-N'-nitro-N-nitrosoguanidine-induced gastrointestinal cancer in rats.
In this study, Ganoderma lucidum extract inhibited the growth of gastric cancer cell lines.
Food Funct. 2014 Jul 25;5(7):1389-94. doi: 10.1039/c4fo00258j.
A methanolic extract of Ganoderma lucidum fruiting body inhibits the growth of a gastric cancer cell line and affects cellular autophagy and cell cycle.
Patrinia heterophylla bunge extract causes apoptosis in gastric cancer cells, therefore providing a potential therapeutic agent for treatment of gastric cancer.
Asian Pac J Cancer Prev. 2013;14(11):6481-6.
Induction of cytotoxicity and apoptosis in human gastric cancer cell SGC-7901 by isovaltrate acetoxyhydrin isolated from Patrinia heterophylla bunge involves a mitochondrial pathway and G2/M phase cell cycle arrest.
In this Study, Astragalus saponins inhibited human gastric cancer cell growth, decreased invasion ability and induced apoptosis.
Diagn Pathol. 2013 Oct 24;8:179. doi: 10.1186/1746-1596-8-179.
Astragalus saponins affect proliferation, invasion and apoptosis of gastric cancer BGC-823 cells.
Buxus Microphylla inhibits the growth and the survival of gastric cancer cells.
J Pharmacopuncture. 2013 Sep;16(3):39-45. doi: 10.3831/KPI.2013.16.016.
Buxus Microphylla var. Koreana Nakai Extract for the Treatment of Gastric Cancer.
Ramson water extract induced apoptosis in human AGS gastric cancer cells.
Onco Targets Ther. 2013 Jun 25;6:779-83. doi: 10.2147/OTT.S45865. Print 2013.
Apoptosis and G2/M arrest induced by Allium ursinum (ramson) watery extract in an AGS gastric cancer cell line.
Ethyl acetate extract of Memecylon edule induces apoptosis selectively in gastric cancer cells.
Asian Pac J Trop Med. 2013 May 13;6(5):337-45. doi: 10.1016/S1995-7645(13)60036-X.
Apoptogenic activity of ethyl acetate extract of leaves of Memecylon edule on human gastric carcinoma cells via mitochondrial dependent pathway.
This study shows Atractylodes lancea inhibited the growth of human gastric cancer cells.
Cytotechnology. 2014 Mar;66(2):201-8. doi: 10.1007/s10616-013-9559-1. Epub 2013 Apr 7.
Selective fraction of Atractylodes lancea (Thunb.) DC. and its growth inhibitory effect on human gastric cancer cells.
Ethanol Extract of Gleditsia sinensis thorns shows inhibition of gastric cancer cell growth.
Oncol Rep. 2013 Apr;29(4):1609-16. doi: 10.3892/or.2013.2271. Epub 2013 Feb 4.
Suppressive effects of an ethanol extract of Gleditsia sinensis thorns on human SNU-5 gastric cancer cells.
Paeonia suffruticosa extract might be a potential anti-cancer agent for gastric cancer.
J Biomed Sci. 2012 Sep 10;19:82. doi: 10.1186/1423-0127-19-82.
Ethanol extract of paeonia suffruticosa Andrews (PSE) induced AGS human gastric cancer cell apoptosis via fas-dependent apoptosis and MDM2-p53 pathways.
Sargassum pallidum aqueous extract may enhance immunity and antioxidant activities in gastric cancer.
Molecules. 2012 Jul 11;17(7):8419-29. doi: 10.3390/molecules17078419.
Evaluation of antioxidant and immunity-enhancing activities of Sargassum pallidum aqueous extract in gastric cancer rats.
Orostachys japonica extract has substantial anti-cancer activity in human gastric cancer cells.
Biol Pharm Bull. 2012;35(5):660-5.
Effects of the ethylacetate extract of Orostachys japonicus on induction of apoptosis through the p53-mediated signaling pathway in human gastric cancer cells.
Lactobacillus casei extract induces apoptosis in gastric cancer cells.
Integr Cancer Ther. 2013 Mar;12(2):165-73. doi: 10.1177/1534735412442380. Epub 2012 Apr 13.
Lactobacillus casei extract induces apoptosis in gastric cancer by inhibiting NF-κB and mTOR-mediated signaling.
Extract of Ecballium elaterium fruit has a cytotoxic effect on gastric cancer cell lines by means of apoptosis.
J Gastrointest Cancer. 2012 Dec;43(4):579-83. doi: 10.1007/s12029-012-9383-4.
Cytotoxic effect of freeze-dried extract of Ecballium elaterium fruit on gastric adenocarcinoma (AGS) and esophageal squamous cell carcinoma (KYSE30) cell lines.