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Gastric and Esophageal Cancer Research

in the peer-reviewed medical literature

None of the 700+ studies listed on this site can substitute for consulting a licensed naturopathic physician.  And none can be expected to function as stand-alone, at-home treatment.

High-dose vitamin C decreased esophageal cancer tumors in rats.


Acta Cir Bras. 2009 May-Jun;24(3):183-8.

Role of the vitamin C in diethylnitrosamine-induced esophageal cancer in Wistar rats.

Ramos AC1, Araujo MR, Lopes LR, Andreollo NA.



Curcumin may be considered a novel therapeutic strategy to inhibit gastric cancer cell growth.


Oncol Lett. 2016 Dec;12(6):5156-5162. doi: 10.3892/ol.2016.5354. Epub 2016 Nov 4.

Curcumin suppresses the proliferation of gastric cancer cells by downregulating H19.

Liu G1, Xiang T2, Wu QF1, Wang WX3. Lee J1, Cho K.


Higher intake of dietary vitamin C might have a protective effect against esophageal cancer.


Int J Cancer. 2016 Apr 15;138(8):1843-50. doi: 10.1002/ijc.29838. Epub 2015 Oct 15.

Association between dietary vitamin C intake and risk of esophageal cancer: A dose-response meta-analysis.

Bo Y1, Lu Y2, Zhao Y3, Zhao E3, Yuan L3, Lu W3, Cui L1, Lu Q1.



Weikang Keli once a day for 25 days could significantly reduce gastric tumor volumes by about 50%.


Phytomedicine. 2013 Jan 15;20(2):159-65. doi: 10.1016/j.phymed.2012.10.001. Epub 2012 Nov 8.

Chinese medicine formula "Weikang Keli" induces autophagic cell death on human gastric cancer cell line SGC-7901.

Huo J1, Qin FCai XJu JHu CWang ZLu WWang XCao P.

Lysine may be a potential therapeutic tool for gastric cancer management.


Am J Cancer Res. 2014 Dec 15;5(1):87-100. eCollection 2015.

KDM5B is overexpressed in gastric cancer and is required for gastric cancer cell proliferation and metastasis.

Wang Z1, Tang F2, Qi G3, Yuan S4, Zhang G5, Tang B4, He S4.


Vitamins can significantly reduce the risk of gastric cancer, especially vitamin A, vitamin C, vitamin E.


PLoS One. 2014 Dec 30;9(12):e116060. doi: 10.1371/journal.pone.0116060. eCollection 2014.

Vitamin intake reduce the risk of gastric cancer: meta-analysis and systematic review of randomized and observational studies.

Kong P1, Cai Q2, Geng Q3, Wang J4, Lan Y5, Zhan Y1, Xu D1.


Weichang'an Decoction slows tumor growth and metastasis of gastric cancer.


Zhong Xi Yi Jie He Xue Bao. 2005 Sep;3(5):378-81.

[Growth-inhibiting and anti-metastasis effects of Weichang'an Decoction on orthotopic transplant nude mouse model of human gastric cancer].

[Article in Chinese]

Zhao HL1, Zhao AGYou SFGu YTang LDYang JK.


Aster tataricus induces apoptosis of gastric cancer cells.


Int J Biol Macromol. 2012 Nov;51(4):509-13. doi: 10.1016/j.ijbiomac.2012.06.019. Epub 2012 Jun 19.

Inhibition of human gastric carcinoma cell growth in vitro by a polysaccharide from Astertataricus.

Zhang Y1, Wang QWang TZhang HTian YLuo HYang SWang YHuang X.

Nitrate is a well-studied gastric carcinogen.  Vitamin C / ascorbic acid reduced carcinogenic nitrates to nitrites.

Ann N Y Acad Sci. 1975 Sep 30;258:181-9.

Reduction of gastric carcinogens with ascorbic acid.

Raineri RWeisburger JH.

Celastrus orbiculatus not only has significant antiproliferative effects but also has both in vivo and in vitro apoptotic effects in Gastric Cancer.

J Ethnopharmacol. 2017 May 2. pii: S0378-8741(17)30727-4. doi: 10.1016/j.jep.2017.04.030. [Epub ahead of print]

Anticancer efficacy of the ethyl acetate extract from the traditional Chinese medicine herb Celastrus orbiculatus against human gastric cancer.

Wang H1, Tao L2, Ni T3, Gu H4, Jin F5, Dai X6, Feng J7, Ding Y8, Xiao W9, Guo S10, Hisamitsu T11, Qian Y12, Liu Y13.


Flavone Polyphenols inhibited cell proliferation and induced cell death in Gastric Adenocarcinoma.


J Chromatogr B Analyt Technol Biomed Life Sci. 2017 May 15;1053:1-8. doi: 10.1016/j.jchromb.2017.03.035. Epub 2017 Mar 31.

Flavone polyphenols dominate in Thymus schimperi Ronniger: LC-ESI-MS/MS characterization and study of anti-proliferative effects of plant extract on AGS and HepG2 cancer cells.

Desta KT1, Kim GS2, El-Aty AMA3, Raha S2, Kim MB4, Jeong JH5, Warda M6, Hacımüftüoğlu A7, Shin HC8, Shim JH9, Shin SC10.



Rosmarinus officinalis represents a promising anticancer agent against gastric cancer.


Phytomedicine. 2016 Dec 1;23(13):1671-1679. doi: 10.1016/j.phymed.2016.09.008. Epub 2016 Sep 24.

Sageone, a diterpene from Rosmarinus officinalis, synergizes with cisplatin cytotoxicity in SNU-1 human gastric cancer cells.

Shrestha S1, Song YW2, Kim H1, Lee DS3, Cho SK4.



The present study demonstrated that Urtica dioica inhibited proliferation of gastric and colorectal cancer cells while posing no significant toxic effect on normal cells.


Cell Mol Biol 2016 Oct 15;62(9):90-96.

Cytotoxic effects of Urtica dioica radix on human colon (HT29) and gastric (MKN45) cancer cells mediated through oxidative and apoptotic mechanisms.

Ghasemi S1, Moradzadeh M2, Mousavi SH3, Sadeghnia HR4.


Astragalus extract enhances apoptosis in gastric cancer cells in vitro and in vivo.


Pak J Pharm Sci. 2016 Sep;29(5):1473-1482.

Astragalus extract inhibits proliferation but enhances apoptosis in gastric cancer.

Wang Z1, Dong L2, Zhen Y2, Wang Y2, Qi D3, Xu A3, Meng X2, Li W2.


Novel polysaccharide from algae extract induces cancer cell apoptosis and arrested cell cycle in gastric cancer cells.


Int J Oncol. 2016 Oct;49(4):1561-1568. doi: 10.3892/ijo.2016.3658. Epub 2016 Aug 18.

A novel polysaccharide derived from algae extract induces apoptosis and cell cycle arrest in human gastric carcinoma MKN45 cells via ROS/JNK signaling pathway.

Xie P1, Fujii I1, Zhao J2, Shinohara M2, Matsukura M1.



Scutellaria barbata can inhibit the proliferation and promote apoptosis of human gastric adenocarcinoma cells.


J Pharmacopuncture. 2016 Jun;19(2):129-36. doi: 10.3831/KPI.2016.19.014.

Inductions of Caspase-, MAPK- and ROS-dependent Apoptosis and Chemotherapeutic Effects Caused by an Ethanol Extract of Scutellaria barbata D. Don in Human Gastric Adenocarcinom Cells.

Shim JH1, Gim H1, Lee S1, Kim BJ1.



Bornyl acetate, from the plant Blumea balsamifera, potentiates anticancer activity in human gastric cancer cells by inducing apoptosis.


J BUON. 2016 Jan-Feb;21(1):108-17.

Synergistic enhancement of the antitumor activity of 5-fluorouracil by bornyl acetate in SGC-7901 human gastric cancer cells and the determination of the underlying mechanism of action.

Li J1, Wang SX.



In this study, Euphorbia esula extract inhibited proliferation and induced apoptosis in human gastric carcinoma.


World J Gastroenterol. 2016 Apr 7;22(13):3564-72. doi: 10.3748/wjg.v22.i13.3564.

Apoptosis of human gastric carcinoma cells induced by Euphorbia esula latex.

Fu ZY1, Han XD1, Wang AH1, Liu XB1.



Huaier fungus inhibits tumorigenic capacity of human gastric cancer cells.


J Ethnopharmacol. 2016 Jun 20;186:143-50. doi: 10.1016/j.jep.2016.03.069. Epub 2016 Apr 1.

Huaier aqueous extract sensitizes cells to rapamycin and cisplatin through activating mTOR signaling.

Hu Z1, Yang A2, Fan H3, Wang Y4, Zhao Y1, Zha X5, Zhang H6, Tu P7.



Black currant extract may be a promising anticancer candidate for gastric cancer.


J Med Food. 2016 Apr;19(4):365-73. doi: 10.1089/jmf.2015.3521. Epub 2016 Mar 23.

Black Currant (Ribes nigrum L.) Extract Induces Apoptosis of MKN-45 and TE-1 Cells Through MAPK- and PI3K/Akt-Mediated Mitochondrial Pathways.

Liu B1, Li Z1.



Ginkgo biloba extract could inhibit gastric cancer proliferation through adjusting cell cycle and inducing cell apoptosis.


Int J Clin Exp Med. 2015 Nov 15;8(11):20977-82. eCollection 2015.

Ginkgo biloba extract induce cell apoptosis and G0/G1 cycle arrest in gastric cancer cells.

Bai Y1, Zhao F2, Li Y3, Wang L4, Fang XJ4, Wang CY5.



The caper plant inhibits proliferation, and apoptosis was induced in gastric cancer cells.


Exp Ther Med. 2015 Dec;10(6):2403-2409. Epub 2015 Sep 25.

In vitro analysis of the role of the mitochondrial apoptosis pathway in CSBE therapy against human gastric cancer.

Ji YB1, Yu L1.



Dictamnus extract induces apoptosis of AGS human gastric adenocarcinoma cells.


Pharmacogn Mag. 2015 Oct;11(Suppl 2):S329-36. doi: 10.4103/0973-1296.165994.

Apoptosis of AGS human gastric adenocarcinoma cells by methanolic extract of Dictamnus.

Park HS1, Hong NR1, Ahn TS1, Kim H2, Jung MH1, Kim BJ1.


Ethanolic extract of Tulipa edulis bak may inhibit the growth of human gastric cancer by causing apoptosis in the cancer cells.


Oncol Lett. 2015 Oct;10(4):2371-2377. Epub 2015 Jul 16.

Ethanolic extract of Tulipa edulis Bak induces apoptosis in SGC-7901 human gastric carcinoma cells via the mitochondrial signaling pathway.

Lin R1, Li Z1, Lin J1, Ye J1, Cai Q1, Chen L2, Peng J1.



Ginkgo biloba extract conferred an inhibitory effect on the proliferation of gastric carcinoma cells.


Clin Transl Oncol. 2016 May;18(5):521-6. doi: 10.1007/s12094-015-1399-3. Epub 2015 Oct 21.

The effect of EGB on proliferation of gastric carcinoma SGC7901 cells.

Qian Y1, Xia L2, Shi W1, Sun JJ1, Sun YQ3.



In this study, supercritical fluid extract of Phalsak induced apoptosis with inhibition of human gastric cancer cells.


Evid Based Complement Alternat Med. 2015;2015:402385. doi: 10.1155/2015/402385. Epub 2015 Aug 13.

Auraptene, a Major Compound of Supercritical Fluid Extract of Phalsak (Citrus Hassaku Hort ex Tanaka), Induces Apoptosis through the Suppression of mTOR Pathways in Human Gastric Cancer SNU-1 Cells.

Moon JY1, Kim H1, Cho SK2.



This study revealed the cytotoxic effect of the aqueous extract of Agrostemma githago seed on gastric cancer cells.


J Ethnopharmacol. 2015 Dec 4;175:295-300. doi: 10.1016/j.jep.2015.07.010. Epub 2015 Jul 18.

Aqueous extract of Agrostemma githago seed inhibits caspase-3 and induces cell-cycle arrest at G1 phase in AGS cell line.

Bohlooli S1, Bohlooli S2, Aslanian R3, Nouri F2, Teimourzadeh A4.



Eucommia ulmoides oliver extract exhibited potential anti-tumor activity for AGS gastric cancer cell.


J Food Sci Technol. 2015 Aug;52(8):4925-34. doi: 10.1007/s13197-014-1571-8. Epub 2014 Sep 30.

Microwave-assisted extraction and purification of chlorogenic acid from by-products of Eucommia Ulmoides Oliver and its potential anti-tumor activity.

Shao P1, Zhang JF1, Chen XX1, Sun PL1.


Cordyceps taii has potent in vivo antitumor and antimetastatic activities in gastric cancer cells.


BMC Complement Altern Med. 2015 Jul 9;15:216. doi: 10.1186/s12906-015-0762-9.

Antitumor and antimetastatic activities of chloroform extract of medicinal mushroom Cordyceps taii in mouse models.

Liu RM1, Zhang XJ2, Liang GY3, Yang YF4, Zhong JJ5, Xiao JH6.



Rheum undulatum mediates cell death associated with an intrinsic apoptotic pathway in human adenocarcinoma gastric cell lines.


J Pharmacopuncture. 2015 Jun;18(2):26-32. doi: 10.3831/KPI.2015.18.012.

Association of a Methanol Extract of Rheum undulatum L. Mediated Cell Death in AGS Cells with an Intrinsic Apoptotic Pathway.

Hong NR1, Park HS1, Ahn TS1, Jung MH1, Kim BJ1.



Alocasia cucullate compounds may be a potential source of novel compounds for gastric cancer treatment.


BMC Complement Altern Med. 2015 Feb 26;15:33. doi: 10.1186/s12906-015-0554-2.

Antitumor effect and apoptosis induction of Alocasia cucullata (Lour.) G. Don in human gastric cancer cells in vitro and in vivo.

Wei P1,2, Zhiyu C3,4, Xu T5, Xiangwei Z6.



Extract of Zuojin Pill can potentially serve as an antitumor agent.


Chin J Integr Med. 2015 Nov;21(11):837-45. doi: 10.1007/s11655-015-2043-3. Epub 2015 Apr 6.

Extract of Zuojin Pill ([characters: see text]) induces apoptosis of SGC-7901 cells via mitochondria-dependent pathway.

Peng QX1,2, Cai HB1, Peng JL3, Yung KL2, Shi J2, Mo ZX4.



Celastrus orbiculatus may be considered a novel anticancer agent for the treatment of metastasis in gastric cancer.


Integr Cancer Ther. 2015 May;14(3):271-81. doi: 10.1177/1534735415572880. Epub 2015 Feb 26.

Antimetastatic effects of Celastrus orbiculatus on human gastric adenocarcinoma by inhibiting epithelial-mesenchymal transition and NF-κB/snail signaling pathway.

Zhu Y1, Liu Y2, Qian Y1, Dai X3, Yang L1, Chen J1, Guo S4, Hisamitsu T4.



Extract of Silybum marianum inhibits ADA activity in cancerous gastric tissues significantly.


Pharmacogn Mag. 2015 Jan-Mar;11(41):143-6. doi: 10.4103/0973-1296.149729.

Effects of aqueous extract from Silybum marianum on adenosine deaminase activity in cancerous and noncancerous human gastric and colon tissues.

Öztürk B1, Kocaoğlu EH2, Durak ZE3.



Prunella vulgaris fungus extract exhibits a growth-suppressive activity on gastric cancer.


Oncol Lett. 2015 Feb;9(2):945-949. Epub 2014 Nov 20.

Extracts of endophytic fungus xkc-s03 from Prunella vulgaris L. spica inhibit gastric cancer in vitro and in vivo.

Tan J1, Qi H1, Ni J1.



Ferulago has cytotoxic and apoptosis-inducing effects on gastric cancer cell lines.


Iran J Pharm Res. 2014 Fall;13(4):1335-45.

Anti-tumor Activity of Ferulago angulata Boiss. Extract in Gastric Cancer Cell Line via Induction of Apoptosis.

Heidari S1, Akrami H1, Gharaei R1, Jalili A2, Mahdiuni H1, Golezar E1.




Ethanol extract of Radix glycyrrhizae has an anti-proliferative activity on human gastric cancer cells.


Afr J Tradit Complement Altern Med. 2014 Jan 28;11(2):334-8. eCollection 2014.

Studies on the identification of constituents in ethanol extract of Radix Glycyrrhizae and their anticancer activity.

Shi X1, Zou M1, He J1, Xie H1, Li X1.



Celastrus orbiculatus may be considered a novel anti-cancer agent for the treatment of metastasis in gastric cancer.


BMC Complement Altern Med. 2014 Nov 5;14:433. doi: 10.1186/1472-6882-14-433.

Research on the efficacy of Celastrus Orbiculatus in suppressing TGF-β1-induced epithelial-mesenchymal transition by inhibiting HSP27 and TNF-α-induced NF-κ B/Snail signaling pathway in human gastric adenocarcinoma.

Zhu YLiu Y1, Qian YDai XYang LChen JGuo SHisamitsu T.



Aqueous extract of Alpinia galangal has anti-proliferative effect on human gastric cancer.


Iran J Cancer Prev. 2014 Summer;7(3):142-6.

The Effects of Aqueous Extract of Alpinia Galangal on Gastric Cancer Cells (AGS) and L929 Cells in Vitro.

Hadjzadeh MA1, Ghanbari H1, Keshavarzi Z2, Tavakol-Afshari J3.



Schizandra chinensis extracts might be an effective chemotherapeutic for the treatment of human gastric cancer.


Pharm Biol. 2015 Feb;53(2):212-9. doi: 10.3109/13880209.2014.913297. Epub 2014 Sep 22.

Schizandra chinensis extracts induce apoptosis in human gastric cancer cells via JNK/p38 MAPK activation and the ROS-mediated/mitochondria-dependent pathway.

Kim HS1, Lee JHPark HSLee GSKim HWHa KTKim BJ.


Actinidia valvata dunn extract exhibits an obvious preventive effect on gastrointestinal carcinogenesis through the regulation of cell proliferation and apoptosis.


Asian Pac J Cancer Prev. 2014;15(15):6363-7.

Preventive effect of Actinidia valvata Dunn extract on N-methyl-N'-nitro-N-nitrosoguanidine-induced gastrointestinal cancer in rats.

Wang X1, Liu HWang XZeng ZXie LQSun ZGWei MX.



In this study, Ganoderma lucidum extract inhibited the growth of gastric cancer cell lines.


Food Funct. 2014 Jul 25;5(7):1389-94. doi: 10.1039/c4fo00258j.

A methanolic extract of Ganoderma lucidum fruiting body inhibits the growth of a gastric cancer cell line and affects cellular autophagy and cell cycle.

Oliveira M1, Reis FSSousa DTavares CLima RTFerreira ICdos Santos TVasconcelos MH.


Patrinia heterophylla bunge extract causes apoptosis in gastric cancer cells, therefore providing a potential therapeutic agent for treatment of gastric cancer.


Asian Pac J Cancer Prev. 2013;14(11):6481-6.

Induction of cytotoxicity and apoptosis in human gastric cancer cell SGC-7901 by isovaltrate acetoxyhydrin isolated from Patrinia heterophylla bunge involves a mitochondrial pathway and G2/M phase cell cycle arrest.

Yang B1, Wang YQCheng RBChen JLChen JJia LTZhang RS.



In this Study, Astragalus saponins inhibited human gastric cancer cell growth, decreased invasion ability and induced apoptosis. 


Diagn Pathol. 2013 Oct 24;8:179. doi: 10.1186/1746-1596-8-179.

Astragalus saponins affect proliferation, invasion and apoptosis of gastric cancer BGC-823 cells.

Wang TXuan XLi MGao PZheng YZang W1, Zhao G.



Buxus Microphylla inhibits the growth and the survival of gastric cancer cells.


J Pharmacopuncture. 2013 Sep;16(3):39-45. doi: 10.3831/KPI.2013.16.016.

Buxus Microphylla var. Koreana Nakai Extract for the Treatment of Gastric Cancer.

Lee HJ1, Kim MC1, Lim B1, Kim BJ1.


Ramson water extract induced apoptosis in human AGS gastric cancer cells.


Onco Targets Ther. 2013 Jun 25;6:779-83. doi: 10.2147/OTT.S45865. Print 2013.

Apoptosis and G2/M arrest induced by Allium ursinum (ramson) watery extract in an AGS gastric cancer cell line.

Xu XY1, Song GQYu YQMa HYMa LJin YN.



Ethyl acetate extract of Memecylon edule induces apoptosis selectively in gastric cancer cells.


Asian Pac J Trop Med. 2013 May 13;6(5):337-45. doi: 10.1016/S1995-7645(13)60036-X.

Apoptogenic activity of ethyl acetate extract of leaves of Memecylon edule on human gastric carcinoma cells via mitochondrial dependent pathway.

Naidu VG1, Mahesh BUGiddam AKBabu KRDing J, Babu KSRamesh BPragada RRGopalakrishnakone P.



This study shows Atractylodes lancea inhibited the growth of human gastric cancer cells. 


Cytotechnology. 2014 Mar;66(2):201-8. doi: 10.1007/s10616-013-9559-1. Epub 2013 Apr 7.

Selective fraction of Atractylodes lancea (Thunb.) DC. and its growth inhibitory effect on human gastric cancer cells.

Zhao M1, Wang QOuyang ZHan BWang WWei YWu YYang B.



Ethanol Extract of Gleditsia sinensis thorns shows inhibition of gastric cancer cell growth.


Oncol Rep. 2013 Apr;29(4):1609-16. doi: 10.3892/or.2013.2271. Epub 2013 Feb 4.

Suppressive effects of an ethanol extract of Gleditsia sinensis thorns on human SNU-5 gastric cancer cells.

Lee SJ1, Ryu DHJang LCCho SCKim WJMoon SK.


Paeonia suffruticosa extract might be a potential anti-cancer agent for gastric cancer.


J Biomed Sci. 2012 Sep 10;19:82. doi: 10.1186/1423-0127-19-82.

Ethanol extract of paeonia suffruticosa Andrews (PSE) induced AGS human gastric cancer cell apoptosis via fas-dependent apoptosis and MDM2-p53 pathways.

Choi HS1, Seo HSKim JHUm JYShin YCKo SG.


Sargassum pallidum aqueous extract may enhance immunity and antioxidant activities in gastric cancer.


Molecules. 2012 Jul 11;17(7):8419-29. doi: 10.3390/molecules17078419.

Evaluation of antioxidant and immunity-enhancing activities of Sargassum pallidum aqueous extract in gastric cancer rats.

Zhang RL1, Luo WDBi TNZhou SK.



Orostachys japonica extract has substantial anti-cancer activity in human gastric cancer cells.


Biol Pharm Bull. 2012;35(5):660-5.

Effects of the ethylacetate extract of Orostachys japonicus on induction of apoptosis through the p53-mediated signaling pathway in human gastric cancer cells.

Ryu DS1, Lee HSLee GSLee DS.


Lactobacillus casei extract induces apoptosis in gastric cancer cells.


Integr Cancer Ther. 2013 Mar;12(2):165-73. doi: 10.1177/1534735412442380. Epub 2012 Apr 13.

Lactobacillus casei extract induces apoptosis in gastric cancer by inhibiting NF-κB and mTOR-mediated signaling.

Hwang JW1, Baek YMYang KEYoo HSCho CKLee YWPark JEom CYLee ZWChoi JSJang IS.



Extract of Ecballium elaterium fruit has a cytotoxic effect on gastric cancer cell lines by means of apoptosis.


J Gastrointest Cancer. 2012 Dec;43(4):579-83. doi: 10.1007/s12029-012-9383-4.

Cytotoxic effect of freeze-dried extract of Ecballium elaterium fruit on gastric adenocarcinoma (AGS) and esophageal squamous cell carcinoma (KYSE30) cell lines.

Bohlooli S1, Jafari NJahed S.

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