Liver and Biliary Tract Cancer Research
in the peer-reviewed medical literature
None of the 700+ studies listed on this site can substitute for consulting a licensed naturopathic physician. And none can be expected to function as stand-alone, at-home treatment.
A case study of high dose vitamin C bringing about regression of multiple pulmonary metastases from liver cancer.
Yonsei Med J. 2015 Sep;56(5):1449-52. doi: 10.3349/ymj.2015.56.5.1449.
High-Dose Vitamin C Promotes Regression of Multiple Pulmonary Metastases Originating from Hepatocellular Carcinoma.
This paper examines the essential role in cancer prevention derivatives from plants have played due to their pleiotropic abilities to scavenge free radicals, inhibit cell growth and induce apoptosis.
Anticancer Agents Med Chem. 2018 Jun 3. doi: 10.2174/1871520618666180604085612. [Epub ahead of print]
Rosmarinic acid, isolated from herbal balm mint plants, has demonstrated anti-tumor properties against liver cancer.
Biomed Pharmacother. 2018 Jun 1;105:334-349. doi: 10.1016/j.biopha.2018.05.129. [Epub ahead of print]
Proteomics analysis demonstrating rosmarinic acid suppresses cell growth by blocking the glycolytic pathway in human HepG2 cells.
Antitumor effects of Oroxin B (a flavonoid isolated from Oroxylum indicum) were demonstrated along with the possible molecular pathway mechanism involved.
Pharmacogn Mag. 2018 Apr-Jun;14(54):207-213. doi: 10.4103/pm.pm_119_17. Epub 2018 Apr 10.
Evidence for the Involvement of COX-2/VEGF and PTEN/Pl3K/AKT Pathway the Mechanism of Oroxin B Treated Liver Cancer.
Anticarginogenic effects of Garcinia mangostana on the development of liver cancer.
Pharmacogn Mag. 2018 Apr-Jun;14(54):186-190. doi: 10.4103/pm.pm_213_17. Epub 2018 Apr 10.
Biochemical Evidence for the Antitumor Potential of Garcinia mangostana Linn. On Diethylnitrosamine-Induced Hepatic Carcinoma.
Efficacy of traditional herbal medicine was compared and found to be superior to that of transarterial chemoembolization in small hepatocellular carcinoma post surgery.
Cancer. 2018 May 15;124(10):2161-2168. doi: 10.1002/cncr.30915. Epub 2018 Mar 2.
Traditional herbal medicine prevents postoperative recurrence of small hepatocellular carcinoma: A randomized controlled study.
The herbal formula Yang-Gan Jie-Du Sang-Jie was found to inhibit anchorage-independent growth in human hepatocellular carcinoma Bel-7402 cells.
BMC Complement Altern Med. 2018 Jan 16;18(1):17. doi: 10.1186/s12906-018-2083-2
Herbal formula YGJDSJ inhibits anchorage-independent growth and induces anoikis in hepatocellular carcinoma Bel-7402 cells.
Effects of Salvia chinensia Benth exhibited prominent inhibition of and suppressed the orthotopic growth of hepatocellular carcinoma cells in mice livers.
Oncotarget. 2017 Nov 11;8(62):105848-105859. doi: 10.18632/oncotarget.22406. eCollection 2017 Dec 1.
Identification of WT1 as determinant of heptatocellular carcinoma and its inhibition by Chinese herbal medicine Salvia chinensis Benth and its active ingredient protocatechualdehyde.
Trametes robiniophila Murr was found to inhibit proliferation and migration of hepatocellular carcinoma.
J Cancer. 2017 Nov 6;8(19):4087-4097. doi: 10.7150/jca.21018. eCollection 2017.
Huaier Restrains Proliferative and Migratory Potential of Hepatocellular Carcinoma Cells Partially Through Decreased Yes-Associated Protein 1.
Rhododendron luteum extract shows ability to selectively kill colon cancer and liver cancer cells.
J BUON. 2016 Jul-Aug;21(4):883-888.
Selective cytotoxic effect of Rhododendron luteum extract on human colon and liver cancer cells.
Essential oils from Rosmarinus officinalis can affect the pattern of bcl-2 and bax genes expressions, and this may increase the apoptosis of liver cancer cell line HepG2.
Zhong Yao Cai. 2008 Jun;31(6):877-9.
[Expression of bcl-2 and bax genes in the liver cancer cell line HepG2 after apoptosis induced by essential oils from Rosmarinus officinalis].
[Article in Chinese]
When trying to find pain relief for cancer patients, research found that DMSO, sodium bicarbonate, and SAMe was not only helpful relieving pain, but also helped cancer go into remission.
J Pain Palliat Care Pharmacother. 2014 Sep;28(3):206-11. doi: 10.3109/15360288.2014.938882. Epub 2014 Aug 7.
Palliative treatment for advanced biliary adenocarcinomas with combination dimethyl sulfoxide-sodium bicarbonate infusion and S-adenosyl-L-methionine.
An iv nutrient mixture suppressed the growth and liver metastasis of some melanoma cells in lab studies.
Oncol Rep. 2008 Oct;20(4):809-17.
Suppression of growth and hepatic metastasis of murine B16FO melanoma cells by a novel nutrient mixture.
Vitamin E intake, either from diet or supplements, may reduce the risk of liver cancer.
J Natl Cancer Inst. 2012 Aug 8;104(15):1173-81. doi: 10.1093/jnci/djs277. Epub 2012 Jul 17.
Vitamin intake and liver cancer risk: a report from two cohort studies in China.
Mountain peony compounds could be a promising drug to treat liver cancer.
Eur J Pharmacol. 2008 Apr 28;584(2-3):246-52. doi: 10.1016/j.ejphar.2008.02.016. Epub 2008 Feb 15.
Anti-tumor effects of paeonol in a HepA-hepatoma bearing mouse model via induction of tumor cell apoptosis and stimulation of IL-2 and TNF-alpha production.
Artesunate has marked antitumor activity in liver cancer.
Zhongguo Zhong Yao Za Zhi. 2001 Oct;26(10):707-8, 720.
[Experimental studies of antitumor effect of artesunate on liver cancer].
[Article in Chinese]
Curcumin mediates its antiproliferative and apoptotic effects through activation of multiple cell signaling pathways, and thus, its activity against cholangiocarcinoma should be further investigated.
Carcinogenesis. Curcumin suppresses proliferation and induces apoptosis in human biliary cancer cells through modulation of multiple cell signaling pathways. Prakobwong S, et al. 2011. https://www.ncbi.nlm.nih.gov/m/pubmed/21325634/
Cratoxylum formosum extracts induced cell death, stimulated apoptosis and inhibited migration of liver cancer cells.
Biomed Rep. 2017 Apr;6(4):441-448. doi: 10.3892/br.2017.871. Epub 2017 Mar 10.
Cytotoxic and antimigratory effects of Cratoxy formosum extract against HepG2 liver cancer cells.
Gypsophila elegans has the ability to induce apoptosis against liver cancer cells.
J Ethnopharmacol. 2016 Jul 1;187:187-94. doi: 10.1016/j.jep.2016.04.050. Epub 2016 Apr 27.
Isoorientin from Gypsophila elegans induces apoptosis in liver cancer cells via mitochondrial-mediated pathway.
Allium atroviolaceum may be useful for the treatment of liver cancer.
Front Pharmacol. 2017 Jan 31;8:5. doi: 10.3389/fphar.2017.00005. eCollection 2017.
In vitro Antiproliferative and Apoptosis Inducing Effect of Allium atroviolaceum Bulb Extract on Breast, Cervical, and Liver Cancer Cells.
Cyphomandra betacea fruits have potential as an effective agent in liver cancer therapy.
Springerplus. 2016 Dec 20;5(1):2105. doi: 10.1186/s40064-016-3777-x. eCollection 2016.
Phenolics profile and anti-proliferative activity of Cyphomandra Betacea fruit in breast and liver cancer cells.
Persian shallot extract could be considered as a potential candidate for the prevention or treatment of liver cancer.
Cytotechnology. 2017 Apr 10. doi: 10.1007/s10616-017-0093-4. [Epub ahead of print]
Persian shallot, Allium hirtifolium Boiss, induced apoptosis in human hepatocellular carcinoma cells.
Ampelopsis sinica root extract may be a potential therapeutic agent in the treatment of hepatocellular carcinoma.
Oncol Rep. 2017 Apr;37(4):2227-2236. doi: 10.3892/or.2017.5504. Epub 2017 Mar 13.
Anti-hepatoma activities of ethyl acetate extract from Ampelopsis sinica root.
Rubus aleaefolius Poir may be a potential novel therapeutic agent for the treatment of hepatocellular carcinoma.
Int J Oncol. 2013 Mar;42(3):971-8. doi: 10.3892/ijo.2013.1779. Epub 2013 Jan 18.
Total alkaloids of Rubus aleaefolius Poir inhibit hepatocellular carcinoma growth in vivo and in vitro via activation of mitochondrial-dependent apoptosis.
Sinomenium acutum plant compounds may serve as a potential drug candidate against hepatocellular carcinoma.
Int J Oncol. 2013 Jan;42(1):229-38. doi: 10.3892/ijo.2012.1704. Epub 2012 Nov 16.
Sinomenine hydrochloride inhibits human hepatocellular carcinoma cell growth in vitro and in vivo: involvement of cell cycle arrest and apoptosis induction.
In this study, oleanolic acid demonstrated significant antitumor activities in liver cancer.
Carcinogenesis. 2013 Jun;34(6):1323-30. doi: 10.1093/carcin/bgt058. Epub 2013 Feb 12.
Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis.
Fenugreek seeds are a promising nontoxic herbal with therapeutic potential to induce apoptosis in liver cancer cells.
Biomed Res Int. 2015;2015:914645. doi: 10.1155/2015/914645. Epub 2015 Oct 18.
Trigonella foenum (Fenugreek) Induced Apoptosis in hepatocellular carcinoma Cell Line, HepG2, Mediated by Upregulation of p53 and Proliferating Cell Nuclear Antigen.
Bistorta officinalis may be a potential new alternative or complementary medicine for liver cancer.
Sci Rep. 2017 Jan 30;7:41437. doi: 10.1038/srep41437.
Aqueous extract of Polygonum bistorta modulates proteostasis by ROS-induced ER stress in human hepatoma cells.
Ginkgo biloba leaves extract show apoptotic and anti-proliferative properties in hepatocellular carcinoma.
Acta Biochim Pol. 2017;64(1):25-33. doi: 10.18388/abp.2015_1200. Epub 2016 Oct 14.
Biochemical and molecular evidences for the antitumor potential of Ginkgo biloba leaves extract in rodents.
In this study, Juniperus chinensis , shows to have anti-angiogenic and anti-hepatocellular activities.
BMC Complement Altern Med. 2016 Aug 8;16:277. doi: 10.1186/s12906-016-1250-6.
Antiangiogenic and antihepatocellular carcinoma activities of the Juniperus chinensis extract.
Saw Palmetto suppressed tumor expansion and may be potential adjuvant treatment for hepatocellular carcinoma.
Int J Mol Sci. 2016 Aug 5;17(8). pii: E1277. doi: 10.3390/ijms17081277.
New Natural Pigment Fraction Isolated from Saw Palmetto: Potential for Adjuvant Therapy of hepatocellular carcinoma.
Elytranthe parasitica active fractions could be a promising contender in the treatment of hepatocellular carcinoma.
BMC Complement Altern Med. 2016 Oct 26;16(1):420.
Pro-apoptotic and cytotoxic effects of enriched fraction of Elytranthe parasitica (L.) Danser against HepG2 hepatocellular carcinoma.
Red sage water compounds may be a chemotherapeutic agent for patients with hepatocellular carcinoma.
Int J Oncol. 2016 Dec;49(6):2538-2548. doi: 10.3892/ijo.2016.3748. Epub 2016 Oct 24.
AKT/mTOR signaling pathway is involved in salvianolic acid B-induced autophagy and apoptosis in hepatocellular carcinoma cells.
Paeonia lactiflora extract has therapeutic potential for the treatment of hepatocellular carcinoma.
Int J Mol Sci. 2016 May 4;17(5). pii: E669. doi: 10.3390/ijms17050669.
Identification of 1,2,3,4,6-Penta-O-galloyl-β-d-glucopyranoside as a Glycine N-Methyltransferase Enhancer by High-Throughput Screening of Natural Products Inhibits hepatocellular carcinoma.
Cordyceps militaris fungus show cytotoxic effects in liver cancer cells.
Mol Med Rep. 2016 Jun;13(6):5132-40. doi: 10.3892/mmr.2016.5175. Epub 2016 Apr 25.
Cordyceps militaris induces tumor cell death via the caspase‑dependent mitochondrial pathway in HepG2 and MCF‑7 cells.
Dioscorea nipponica extract may have potential use as a chemo-preventive agent against liver cancer metastasis.
Am J Chin Med. 2016;44(1):177-95. doi: 10.1142/S0192415X16500129.
Dioscorea nipponica Attenuates Migration and Invasion by Inhibition of Urokinase-Type Plasminogen Activator through Involving PI3K/Akt and Transcriptional Inhibition of NF-[Formula: see text]B and SP-1 in hepatocellular carcinoma.
Compounds found in the plant Scutellaria baicalensis could be a potential therapeutic agent against liver cancer.
Oncol Lett. 2015 Sep;10(3):1831-1835. Epub 2015 Jun 22.
Wogonoside induces apoptosis in Bel-7402, a hepatocellular carcinoma cell line, by regulating Bax/Bcl-2.
Prophylactic dietary supplementation with lycopene-enriched tomato extract may counteract hepatocellular carcinoma progression and/or protect against disease onset.
Nutr Cancer. 2015;67(8):1268-75. doi: 10.1080/01635581.2015.1087040. Epub 2015 Oct 16.
Lycopene Enriched Tomato Extract Inhibits Hypoxia, Angiogenesis, and Metastatic Markers in early Stage N-Nitrosodiethylamine Induced hepatocellular carcinoma.
Grape seed extract could be a promising natural remedy for attenuating hepatocellular carcinoma.
Acta Biochim Pol. 2015;62(3):573-80. doi: 10.18388/abp.2015_1030. Epub 2015 Sep 8.
Current concepts in pathophysiology and management of hepatocellular carcinoma.
Petasites japonicus root extract exerts an anticancer effect on Hep3B hepatocellular carcinoma.
Exp Ther Med. 2015 May;9(5):1791-1796. Epub 2015 Feb 17.
Antiproliferative effect of the methanol extract from the roots of Petasites japonicus on Hep3B hepatocellular carcinoma cells in vitro and in vivo.
Euphorbia helioscopia could effectively inhibit tumor growth, induce apoptosis, and inhibit tumor invasion and metastasis in hepatocellular carcinoma.
Biomed Res Int. 2015;2015:601015. doi: 10.1155/2015/601015. Epub 2015 May 18.
hepatocellular carcinoma Growth Is Inhibited by Euphorbia helioscopia L. Extract in Nude Mice Xenografts.
The plant Rumex vesicarius is an anti-cancer candidate with a promising potential against hepatocellular carcinoma.
Asian Pac J Cancer Prev. 2015;16(10):4303-10.
Significance of Rumex vesicarius as anticancer remedy against hepatocellular carcinoma: a proposal-based on experimental animal studies.
Breadfruit and its dichloromethane fraction can induce autophagic cell death in hepatocellular carcinoma cells.
Am J Chin Med. 2015;43(3):559-79. doi: 10.1142/S0192415X15500354.
Artocarpus communis Induces Autophagic Instead of Apoptotic Cell Death in Human hepatocellular carcinoma Cells.
In this study, toad skin extract exhibited potent therapeutic effect in xenografted human hepatoma without notable side effects.
Oncotarget. 2015 May 10;6(13):11627-39.
ψ-Bufarenogin, a novel anti-tumor compound, suppresses liver cancer growth by inhibiting receptor tyrosine kinase-mediated signaling.
Lingzhi mushroom extract shows inhibition of hepatocellular carcinoma cells.
J Transl Med. 2015 Mar 26;13:100. doi: 10.1186/s12967-015-0465-5.
Ganoderma lucidum polysaccharide extract inhibits hepatocellular carcinoma growth by downregulating regulatory T cells accumulation and function by inducing microRNA-125b.
Hedyotis diffusa may have antiproliferative activity, inhibition of metastasis, and apoptotic effects in induced hepatocellular carcinoma.
Evid Based Complement Alternat Med. 2015;2015:501508. doi: 10.1155/2015/501508. Epub 2015 Mar 10.
Oldenlandia diffusa Promotes Antiproliferative and Apoptotic Effects in a Rat hepatocellular carcinoma with Liver Cirrhosis.
Graptopetalum paraguayense compounds could be considered for the treatment of hepatocellular carcinoma.
PLoS One. 2015 Apr 7;10(4):e0121298. doi: 10.1371/journal.pone.0121298. eCollection 2015.
Evaluation of the medicinal herb Graptopetalum paraguayense as a treatment for liver cancer.
Koidz seed extract has anticancer potency in hepatocellular carcinoma cells.
Evid Based Complement Alternat Med. 2014;2014:192749. doi: 10.1155/2014/192749. Epub 2014 Oct 20.
Akebia trifoliate (Thunb.) Koidz Seed Extract Inhibits the Proliferation of Human hepatocellular carcinoma Cell Lines via Inducing Endoplasmic Reticulum Stress.
Jiedu Xiaozheng Yin extract can inhibit the proliferation of hepatocellular carcinoma.
Oncol Rep. 2014 Dec;32(6):2710-8. doi: 10.3892/or.2014.3541. Epub 2014 Oct 13.
Ethyl acetate extract from Jiedu Xiaozheng Yin inhibits the proliferation of human hepatocellular carcinoma cells by suppressing polycomb gene product Bmi1 and Wnt/β-catenin signaling.
Entada phaseoloides seed extract inhibits liver cancer cell proliferation by inducing cell apoptosis.
J BUON. 2014 Apr-Jun;19(2):406-11.
N-butanol fraction of Entada phaseoloides ethanol extract inhibits hepatocellular carcinoma HepG2 cell proliferation by inducing apoptosis.
Scutellaria baicalensis Georgi could be a potent chemotherapeutic agent against hepatocellular carcinoma.
J Ethnopharmacol. 2014 Aug 8;155(1):847-51. doi: 10.1016/j.jep.2014.05.053. Epub 2014 Jun 6.
Korean Scutellaria baicalensis Georgi methanol extracts inhibits metastasis via the Forkhead Box M1 activity in hepatocellular carcinoma cells.
Cratoxylum formosum extract induced a caspase-dependent apoptosis in liver cancer cells.
Chin Med. 2014 Apr 7;9(1):12. doi: 10.1186/1749-8546-9-12.
Cratoxylum formosum (Jack) Dyer ssp. pruniflorum (Kurz) Gogel. (Hóng yá mù) extract induces apoptosis in human hepatocellular carcinoma HepG2 cells through caspase-dependent pathways.
Livistona chinensis seeds inhibit tumor angiogenesis in hepatocellular carcinoma.
Oncol Rep. 2014 Apr;31(4):1723-8. doi: 10.3892/or.2014.3051. Epub 2014 Feb 24.
Livistona chinensis seeds inhibit hepatocellular carcinoma angiogenesis in vivo via suppression of the Notch pathway.
Extract of Livistona chinensis seed shows an induction of hepatocellular carcinoma cell apoptosis.
Oncol Rep. 2013 May;29(5):1859-66. doi: 10.3892/or.2013.2319. Epub 2013 Mar 1.
Livistona chinensis seed suppresses hepatocellular carcinoma growth through promotion of mitochondrial-dependent apoptosis.
Centella asiatica juice may have the potential to be used as a chemopreventive agent to prevent and treat liver cancer.
BMC Complement Altern Med. 2014 Jan 20;14:32. doi: 10.1186/1472-6882-14-32.
The centella asiatica juice effects on DNA damage, apoptosis and gene expression in hepatocellular carcinoma (HCC).
Strobilanthes crispus juice may have chemopreventive effects on hepatocellular carcinoma cells.
Asian Pac J Cancer Prev. 2015;16(14):6047-53.
Strobilanthes crispus Juice Concentrations and Anticancer Effects on DNA Damage, Apoptosis and Gene Expression in hepatocellular carcinoma Cells.
In this study, Actinidiaceae inhibited growth of hepatocellular carcinoma cell lines.
Pharm Biol. 2016 Aug;54(8):1445-57. doi: 10.3109/13880209.2015.1104699. Epub 2016 Jan 25.
Corosolic acid analogue, a natural triterpenoid saponin, induces apoptosis on human hepatocarcinoma cells through mitochondrial pathway in vitro.
Bolbostemma paniculatum extract may have a great potential as a chemotherapeutic drug candidate for hepatoma.
Biol Pharm Bull. 2011;34(6):831-8.
Natural plant extract tubeimoside I promotes apoptosis-mediated cell death in cultured human hepatoma (HepG2) cells.
Coptis root extract shows antiangiogenic effects on hepatocellular carcinoma cells.
Integr Cancer Ther. 2014 Sep;13(5):425-34. doi: 10.1177/1534735413513635. Epub 2013 Dec 19.
Suppression of vascular endothelial growth factor via inactivation of eukaryotic elongation factor 2 by alkaloids in Coptidis rhizome in hepatocellular carcinoma.
Astragalus and Red Sage extract significantly suppress hepatocellular carcinoma progression.
J Gastroenterol Hepatol. 2014 Jun;29(6):1284-91. doi: 10.1111/jgh.12490.
Compound Astragalus and Salvia miltiorrhiza extracts suppress hepatocarcinogenesis by modulating transforming growth factor-β/Smad signaling.
Curcuma oil can inhibit hepatoma cell growth in vivo and in vitro.
Int J Oncol. 2014 Feb;44(2):505-13. doi: 10.3892/ijo.2013.2184. Epub 2013 Nov 21.
Hepatic protection and anticancer activity of curcuma: a potential chemopreventive strategy against hepatocellular carcinoma.
Scutellaria barbata total flavonoids induces apoptosis in hepatocellular carcinoma cells.
Tumour Biol. 2014 Mar;35(3):2549-59. doi: 10.1007/s13277-013-1336-4. Epub 2013 Nov 13.
Induction of apoptosis by total flavonoids from Scutellaria barbata D. Don in human hepatocarcinoma MHCC97-H cells via the mitochondrial pathway.
Plum blossom extract may be useful for the treatment of hepatocellular carcinoma.
World J Hepatol. 2013 Oct 27;5(10):596-600. doi: 10.4254/wjh.v5.i10.596.
Advanced hepatocellular carcinoma responds to MK615, a compound extract from the Japanese apricot "Prunus mume".
Saussurea involucrata could be used as potential anti-tumor agent in hepatocellular carcinoma.
Asian Pac J Cancer Prev. 2013;14(9):5397-402.
Anti-metastatic potential of ethanol extract of Saussurea involucrata against hepatic cancer in vitro.
Astragalus membranaceus extract may be an important agent against hepatocellular carcinoma via directly inhibiting HCC cell growth.
Oncol Rep. 2012 Dec;28(6):2091-100. doi: 10.3892/or.2012.2035. Epub 2012 Sep 17.
Swainsonine inhibits growth and potentiates the cytotoxic effect of paclitaxel in hepatocellular carcinoma in vitro and in vivo.
In this study, Celastrus orbiculatus significantly inhibited the proliferation of human hepatocellular carcinoma.
Zhonghua Gan Zang Bing Za Zhi. 2012 May;20(5):377-80. doi: 10.3760/cma.j.issn.1007-3418.2012.05.015.
[Acetoacetate extract from Celastrus orbiculatus Thunb inhibits growth of RFP-xenografted human liver carcinoma].
[Article in Chinese]
Common hops acids may be used for prevention and treatment of hepatocellular carcinoma.
Oncol Rep. 2012 Oct;28(4):1423-8. doi: 10.3892/or.2012.1925. Epub 2012 Jul 20.
Hop bitter acids inhibit tumorigenicity of hepatocellular carcinoma cells in vitro.
Shiitake Fungus extract can directly induce apoptosis of liver cancer cells, and thus may have potential chemotherapeutic applications for the treatment of hepatocellular carcinoma.
Biol Pharm Bull. 2012;35(7):1014-21.
Direct cytotoxicity of Lentinula edodes mycelia extract on human hepatocellular carcinoma cell line.
Fennel flower extract has a chemo-preventive effect against the progression into liver malignancy.
Environ Health Prev Med. 2013 Jan;18(1):49-56. doi: 10.1007/s12199-012-0292-8. Epub 2012 Jul 6.
Can methanolic extract of Nigella sativa seed affect glyco-regulatory enzymes in experimental hepatocellular carcinoma?
A nutrient mix of N-acetylcysteine, selenium, copper and zinc is an excellent candidate for therapeutic use in the treatment liver cancer by inhibiting critical parameters in cancer development and progression, such as proliferation, invasion and metastasis, and by inducing apoptosis.
Cancers (Basel). 2012 Mar 23;4(2):323-39. doi: 10.3390/cancers4020323.
Micronutrient Synergy in the Fight against hepatocellular carcinoma.
Beefsteak plant extract suppresses hepatocellular carcinoma tumor growth.
Afr J Tradit Complement Altern Med. 2012 Dec 31;10(2):251-7. eCollection 2013.
Extract of Perilla frutescens inhibits tumor proliferation of HCC via PI3K/AKT signal pathway.
Ginkgo Biloba and Milk Thistle extract may have beneficial chemopreventive roles against the production of liver cancer.
Cancer Cell Int. 2011 Oct 31;11(1):38. doi: 10.1186/1475-2867-11-38.
The chemopreventive effect of Ginkgo biloba and Silybum marianum extracts on hepatocarcinogenesis in rats.
Pulsatilla koreana extract is an effective chemotherapeutic candidate for cancer therapy against hepatocellular carcinoma.
Int J Oncol. 2012 Feb;40(2):452-60. doi: 10.3892/ijo.2011.1204. Epub 2011 Sep 20.
Apoptotic and anti-angiogenic effects of Pulsatilla koreana extract on hepatocellular carcinoma.
Injectable Semen Coicis may induce apoptosis in hepatocellular carcinoma Cells.
Hepatobiliary Pancreat Dis Int. 2011 Jun;10(3):303-7.
hepatocellular carcinoma HepG2 cell apoptosis and caspase-8 and Bcl-2 expression induced by injectable seed extract of Coix lacryma-jobi.
Black nightshade plant extract may be an potent agent for liver cancer treatment through targeting G(2)/M arrest and apoptosis induction, achieving cell growth inhibition.
J Sci Food Agric. 2011 Jan 15;91(1):178-85. doi: 10.1002/jsfa.4170. Epub 2010 Sep 17.
Solanum nigrum L. polyphenolic extract inhibits hepatocarcinoma cell growth by inducing G2/M phase arrest and apoptosis.
Pteris semipinnata extract might have a therapeutic value against human cancer cell lines and especially on hepatocellular carcinoma cells.
Zhong Yao Cai. 2010 Jan;33(1):77-80.
[Apoptosis effect and mechanism of 5F from Pteris semipinnata on HepG2 cells].
[Article in Chinese]
Red Sage extract inhibits invasion and metastasis of hepatocellular carcinoma cells.
Tumori. 2009 Nov-Dec;95(6):789-95.
Tanshinone II-A inhibits invasion and metastasis of human hepatocellular carcinoma cells in vitro and in vivo.
Ardisia pusilla has the potential of inhibition of liver cancer survival, invasion and metastasis.
Phytomedicine. 2012 May 15;19(7):603-8. doi: 10.1016/j.phymed.2012.01.003. Epub 2012 Feb 18.
Ardipusilloside inhibits survival, invasion and metastasis of human hepatocellular carcinoma cells.
Chrysanthemum indicum is a potential novel therapeutic medicinal plant for treatment of HCC or cancer invasion and metastasis.
Oncol Rep. 2010 Feb;23(2):413-21.
Chrysanthemum indicum ethanolic extract inhibits invasion of hepatocellular carcinoma via regulation of MMP/TIMP balance as therapeutic target.
Scutellaria baicalensis shows inhibition of cell proliferation in hepatocellular carcinoma.
Nutr Cancer. 2009;61(4):530-7. doi: 10.1080/01635580902803719.
The effect of Scutellaria baicalensis on the signaling network in hepatocellular carcinoma cells.
Chrysanthemum indicum plant extract could be a promising novel treatment for human hepatocellular carcinoma cancer.
World J Gastroenterol. 2009 Sep 28;15(36):4538-46.
Induction of apoptosis and cell cycle arrest in human HCC MHCC97H cells with Chrysanthemum indicum extract.
Lucidenic acid found in Ganoderma lucidum could serve as a chemopreventive agent for the tumorigenesis and metastasis of highly invasive hepatoma cells.
J Agric Food Chem. 2009 Jun 10;57(11):5049-57. doi: 10.1021/jf900828k.
Inhibitory effects of ganoderma lucidum on tumorigenesis and metastasis of human hepatoma cells in cells and animal models.
Extract of fungi of Huaier suppress not only the growth of hepatocellular carcinoma cells but also tumor angiogenesis and it can induce the apoptosis of hepatocellular carcinoma cells.
J Huazhong Univ Sci Technolog Med Sci. 2009 Apr;29(2):198-201. doi: 10.1007/s11596-009-0212-3. Epub 2009 Apr 28.
Inhibitory effect of extract of fungi of Huaier on hepatocellular carcinoma cells.
Songyou Yin extract inhibits tumor growth and prolonged survival, via inducing apoptosis which indicates its potential use in patients with advanced hepatocellular carcinoma.
J Cancer Res Clin Oncol. 2009 Sep;135(9):1245-55. doi: 10.1007/s00432-009-0566-8. Epub 2009 Mar 10.
Herbal extract "Songyou Yin" inhibits tumor growth and prolongs survival in nude mice bearing human hepatocellular carcinoma xenograft with high metastatic potential.
Japanese apricot extract has an anti-cancer effect against hepatocellular carcinoma.
Hepatogastroenterology. 2007 Sep;54(78):1770-4.
A novel anti-cancer substance, MK615, from ume, a variety of Japanese apricot, inhibits growth of hepatocellular carcinoma cells by suppressing Aurora A kinase activity.
Phellinus rimosus extract has significant chemopreventive properties against NDEA-induced hepatocellular carcinoma.
J Exp Ther Oncol. 2006;5(4):309-21.
Chemopreventive activity of a macrofungus Phellinus rimosus against N-nitrosodiethylamine induced hepatocellular carcinoma in rat.
The extract of Zanthoxylum schinifolium is a good candidate for hepatocellular carcinoma therapy by causing induced cell death in HepG2 cells.
Biol Pharm Bull. 2005 May;28(5):802-7.
The essential oils from Zanthoxylum schinifolium pericarp induce apoptosis of HepG2 human hepatoma cells through increased production of reactive oxygen species.
Cinnamomi Cortex and roots of Scutelleria Radix could be used as potential anti-tumor agent in hepatocellular carcinoma.
Pharmacol Res. 2004 Sep;50(3):279-85.
Inhibitory effect of Sihoga-Yonggol-Moryo-Tang on matrix metalloproteinase-2 and -9 activities and invasiveness potential of hepatocellular carcinoma.
Ginkgo biloba extract significantly can suppress proliferation and increase cytotoxicity in liver cancer cells.
World J Gastroenterol. 2004 Jan;10(1):37-41.
Effects of Ginkgo biloba extract on cell proliferation and cytotoxicity in human hepatocellular carcinoma cells.