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Leukemia and Lymphoma Research

in the peer-reviewed medical literature

None of the 700+ studies listed on this site can substitute for consulting a licensed naturopathic physician.  And none can be expected to function as stand-alone, at-home treatment.

High dose vitamin C killed cells which cause acute myeloid leukemia and similar leukemias without harming any normal human cells.


Ann Hematol. 2015 Nov;94(11):1807-16. doi: 10.1007/s00277-015-2464-2. Epub 2015 Aug 12.

Cytotoxic effects of high concentrations of sodium ascorbate on human myeloid cell lines.

Mastrangelo D1, Massai L2, Lo Coco F3,4, Noguera NI3,4, Borgia L3,4, Fioritoni G5, Berardi A5, Iacone A5, Muscettola M2, Pelosi E6, Castelli G6, Testa U5, Di Pisa F2, Grasso G2.


Dandelion Root Extract has potential as one of the non-toxic and effective alternatives to conventional modes of chemotherapy available today in CMML leukemia.

PLoS One. 2012;7(2):e30604. doi: 10.1371/journal.pone.0030604. Epub 2012 Feb 17.

Efficient induction of extrinsic cell death by dandelion root extract in human chronic myelomonocytic leukemia (CMML) cells.

Ovadje P1, Hamm CPandey S.


This study examines the level of cellular oxidants, cytotoxicity, apoptosis and differentiation induced by hydroalcoholic extract of C. campestris , as well as arsenic trioxide in human leukemic cells.


Avicenna J Phytomed2018 May-Jun;8(3):237-245.

Cuscuta campestris induces apoptosis by increasing reactive oxygen species generation in human leukemic cells.

Moradzadeh MHosseini ARakhshandeh HAghaei ASadeghnia HR.



Stem barks of Drimys brasiliensis (Winteraceae) are widely used to treat gastric and stomach problems and also to treat cancer. This paper examines the efficacy and mechanisms to treat leukemia / lymphoma.


Biomed Pharmacother2018 Jul;103:1498-1506. doi: 10.1016/j.biopha.2018.04.103. Epub 2018 May 7.

Antiproliferative and toxicological properties of drimanes obtained from Drimys brasiliensis stem barks.

Fratoni Ede Athayde AEda Silva Machado MZermiani TVenturi ICorrêa Dos Santos MLobato FCechinel Filho VFranchi GC JrNowill AESantin JRMalheiros A.



Solanine, the main extract of the traditional Chinese herb, Solanum nigrum Linn, may have potential as a novel agent for the treatment of acute lymphocytic leukemia.


Oncol Lett. 2018 May;15(5):7383-7388. doi: 10.3892/ol.2018.8229. Epub 2018 Mar 12.

Solanine induced apoptosis and increased chemosensitivity to Adriamycin in T-cell acute lymphoblastic leukemia cells.

Yi YJJia XHWang JYChen JRWang HLi YJ



This study demonstrates that Northern Labrador tea extracts can exert anti- acute-myeloid-leukemia activity and that this may be attributed to ursolic acid as a constituent component.


Phytother Res. 2018 Apr 27. doi: 10.1002/ptr.6091. [Epub ahead of print]

Therapeutic effect of Northern Labrador tea extracts for acute myeloid leukemia.

McGill CMTomco PLOndrasik RMBelknap KCDwyer GKQuinlan DJKircher TAAndam CPBrown TJClaxton DFBarth BM



This study suggest that matrine, an alkaloid extracted from a Chinese herb, Sophora alopecuroides flavescens Ait, may be a potential anticancer agent.


Asian Pac J Cancer Prev. 2018 Feb 26;19(2):555-560.

Matrine Induction of ROS Mediated Apoptosis in Human ALL B-lymphocytes Via Mitochondrial Targeting

Aghvami MEbrahimi FZarei MHSalimi APourahmad Jaktaji RPourahmad J


These findings indicate that shikonin, an active naphthoquinone derived from the Chinese medical herb Zi Cao, inhibit cell proliferation and induce apoptosis in human leukemia cells.


Mol Med Rep. 2017 Sep;16(3):3055-3060. doi: 10.3892/mmr.2017.6965. Epub 2017 Jul 13.

Shikonin suppresses proliferation and induces apoptosis in human leukemia NB4 cells through modulation of MAPKs and c‑Myc.

Shan ZLZhong LXiao CLGan LGXu TSong HYang RLi LLiu BZ.


Scutellaria orientalis exhibits potent anti-leukemic properties 


Phytomedicine. 2010 Jan;17(1):55-62. doi: 10.1016/j.phymed.2009.06.001. Epub 2009 Jul 2.

In vitro anti-leukemic activity of the ethno-pharmacological plant Scutellaria orientalis ssp. carica endemic to western Turkey.

Ozmen A1, Madlener SBauer SKrasteva SVonach CGiessrigl BGridling MViola KStark NSaiko PMichel BFritzer-Szekeres MSzekeres TAskin-Celik TKrenn LKrupitza G.

Bidens Pilosa is a potentially useful medicinal plant for treatment of T-cell leukemia.

Int J Oncol. 2011 Apr;38(4):1163-73. doi: 10.3892/ijo.2011.939. Epub 2011 Feb 10.

Anti-adult T-cell leukemia effects of Bidens pilosa.

Nakama S1, Ishikawa CNakachi SMori N.


Salvia miltiorrhiza Bunge extract may serve as a potential anti-leukemia reagent.

Oncol Rep. 2009 Apr;21(4):1075-81.

Tanshinone IIA inhibits leukemia THP-1 cell growth by induction of apoptosis.

Liu JJ1, Zhang YLin DJXiao RZ.


Wogonoside may represent a therapeutic candidate for the treatment of Acute myeloid leukemia.


Blood. 2013 May 2;121(18):3682-91. doi: 10.1182/blood-2012-11-466219. Epub 2013 Mar 13.

Wogonoside induces cell cycle arrest and differentiation by affecting expression and subcellular localization of PLSCR1 in AML cells.

Chen Y1, Hui HYang HZhao KQin YGu CWang XLu NGuo Q.



Radix Angelicae Sinensis induces apoptosis and autophagy in human lymphocytic leukemia cells.

Oncol Rep. 2013 May;29(5):2072-8. doi: 10.3892/or.2013.2334. Epub 2013 Mar 6.

Indirubin-3'-monoxime promotes autophagic and apoptotic death in JM1 human acute lymphoblastic leukemia cells and K562 human chronic myelogenous leukemia cells.

Lee MY1, Liu YWChen MHWu JYHo HYWang QFChuang JJ.

In this study, Scutellaria Baicalensis inhibited the growth of ALL, lymphoma and myeloma cell lines by inducing apoptosis.


Leuk Res. 2007 Apr;31(4):523-30. Epub 2006 Sep 26.

Scutellaria baicalensis, a herbal medicine: anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines.

Kumagai T1, Müller CIDesmond JCImai YHeber DKoeffler HP.



Andrographis Paniculata (King of Bitters), is an herbal medicine that showed to cause ROS-dependent apoptosis in lymphoma cell lines.


Clin Cancer Res. 2010 Oct 1;16(19):4755-68. doi: 10.1158/1078-0432.CCR-10-0883. Epub 2010 Aug 26.

Mitochondrial-mediated apoptosis in lymphoma cells by the diterpenoid lactone andrographolide, the active component of Andrographis paniculata.

Yang S1, Evens AMPrachand SSingh ATBhalla SDavid KGordon LI.


Icaritin, a chemical compound found in Barronwart, was found to inhibit T-cell lymphoma cell proliferation and induces apoptosis and cell cycle arrest.


J Exp Clin Cancer Res. 2015 Feb 15;34:17. doi: 10.1186/s13046-015-0133-x.

Icaritin induces lytic cytotoxicity in extranodal NK/T-cell lymphoma.

Wu T1, Wang S2, Wu J3, Lin Z4, Sui X5, Xu X6, Shimizu N7, Chen B8, Wang X9.


Ganoderma lucidum may have a successful immune reaction against B-cell lymphoma.


Int J Surg Pathol. 2007 Apr;15(2):180-6.

Regression of gastric large B-Cell lymphoma accompanied by a florid lymphoma-like T-cell reaction: immunomodulatory effect of Ganoderma lucidum (Lingzhi)?

Cheuk W1, Chan JKNuovo GChan MKFok M.


Berbamine inhibits cell proliferation and induces cell apoptosis in lymphoma cell lines.


Oncol Rep. 2010 Mar;23(3):709-16.

4-Chlorobenzoyl berbamine induces apoptosis and G2/M cell cycle arrest through the PI3K/Akt and NF-kappaB signal pathway in lymphoma cells.

Du HP1, Shen JKYang MWang YQYuan XQMa QLJin J.



Huachansu is effective in inducing cell death and apoptosis in Non-Hodgkin’s Lymphoma.


Int J Oncol. 2015 Aug;47(2):592-600. doi: 10.3892/ijo.2015.3044. Epub 2015 Jun 11.

Huachansu mediates cell death in non-Hodgkin's lymphoma by induction of caspase-3 and inhibition of MAP kinase.

Efuet ET1, Ding XP1, Cartwright C1, Pan Y1, Cohen L1, Yang P1.


Lingzhi mushroom extract has a profound activity against lymphoma.


Leuk Res. 2006 Jul;30(7):841-8. Epub 2006 Jan 19.

Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells.

Müller CI1, Kumagai TO'Kelly JSeeram NPHeber DKoeffler HP.


Plant remedy peptide extract PE-PM stops growth of lymphoma tumor cells.


Biomed Khim. 2009 Jan-Feb;55(1):81-8.

[Antitumor activity of the plant remedy peptide extract PE-PM in a new mouse T-lymphoma/eukemia model].

Chaadaeva AVTenkeeva IIMoiseeva EVSvirshchevskaia EVDemushkin VP.



In this study, Ruta graveolens prevented the spread of lymphoma cells.


J Nat Med. 2017 Jan;71(1):170-180. doi: 10.1007/s11418-016-1046-5. Epub 2016 Oct 13.

Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (V): coumarins and alkaloids from Boenninghausenia japonica and Ruta graveolens.

Nakano D1, Ishitsuka K2, Matsuda N1, Kouguchi A1, Tsuchihashi R1, Okawa M1, Okabe H1, Tamura K3, Kinjo J4.


This study showed that Chinese lacquer tree inhibited the growth of lymphoma cells.


Food Chem Toxicol. 2004 Sep;42(9):1383-8.

Extract from Rhus verniciflua Stokes is capable of inhibiting the growth of human lymphoma cells.

Lee JC1, Lee KY, Kim J, Na CS, Jung NC, Chung GH, Jang YS.



Yunzhi inhibits the proliferation of lymphoma.


Life Sci. 2004 Jul 2;75(7):797-808.

Cytotoxic activities of Coriolus versicolor (Yunzhi) extract on human leukemia and lymphoma cells by induction of apoptosis.

Lau CB1, Ho CYKim CFLeung KNFung KPTse TFChan HHChow MS.


Rhus Verniciflua extract is a natural anti-oxidant that could be used as a cancer chemo-preventive and therapeutic agent in lymphoma cells.


J Biochem Mol Biol. 2003 Jul 31;36(4):337-43.

Ethanol-eluted extract of Rhus verniciflua stokes inhibits cell growth and induces apoptosis in human lymphoma cells.

Lee JC1, Kim JJang YS.



Tea Saponin can markedly inhibit the proliferation and invasiveness of T-lymphoma.


Immunopharmacol Immunotoxicol. 2014 Jun;36(3):202-10. doi: 10.3109/08923973.2014.909849. Epub 2014 Apr 23.

Immunomodulatory effect of tea saponin in immune T-cells and T-lymphoma cells via regulation of Th1, Th2 immune response and MAPK/ERK2 signaling pathway.

Bhardwaj J1, Chaudhary N, Seo HJ, Kim MY, Shin TS, Kim JD.



Ascorbic acid, lysine, proline, green tea extract could be a potential therapeutic treatment in Burkitt's lymphoma and T-cell lymphoma.


Exp Oncol. 2009 Sep;31(3):149-55.

Antineoplastic effects of nutrient mixture on raji and jurkat t cells: the two highly aggressive non Hodgkin's lymphoma cell lines.

Roomi MW, Bhanap BA, Roomi NW, Rath M, Niedzwiecki A.



Ganoderma Lucidum spores can inhibit proliferation of lymphoma cells and induce lymphoma cell apoptosis.


Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Apr;20(2):310-4.

[Inhibitory effects of sporoderm-broken Ganoderma lucidum spores on growth of lymphoma implanted in nude mouse].

Chen J1, Yu YH.



Selenium may have therapeutic relevance to treat lymphoma.


Colloids Surf B Biointerfaces. 2015 Feb 1;126:546-52. doi: 10.1016/j.colsurfb.2015.01.009. Epub 2015 Jan 12.

Carboxylic group-induced synthesis and characterization of selenium nanoparticles and its anti-tumor potential on Dalton's lymphoma cells.

Kumar S1, Tomar MS1, Acharya A2.

Selenium supplementation may offer a novel therapeutic strategy in this frequently curable malignancy in lymphoma.


J Clin Oncol. 2003 Jun 15;21(12):2335-41.

Presentation serum selenium predicts for overall survival, dose delivery, and first treatment response in aggressive non-Hodgkin's lymphoma.

Last KW1, Cornelius V, Delves T, Sieniawska C, Fitzgibbon J, Norton A, Amess J, Wilson A, Rohatiner AZ, Lister TA.


Indole-3-carbinol could be potentially a useful chemotherapeutic agent for patients with T-Cell lymphoma.

Retrovirology. 2009 Jan 16;6:7. doi: 10.1186/1742-4690-6-7.

Anti-adult T-cell leukemia/lymphoma effects of indole-3-carbinol.

Machijima Y1, Ishikawa CSawada SOkudaira TUchihara JNTanaka YTaira NMori N.


Salvia officinalis L. extract inhibits the proliferation of lymphoma and leukemic cells.

Adv Pharm Bull. 2013;3(1):51-5. doi: 10.5681/apb.2013.009. Epub 2013 Feb 7.

Inhibitory and cytotoxic activities of salvia officinalis L. Extract on human lymphoma and leukemia cells by induction of apoptosis.

Zare Shahneh F1, Valiyari SBaradaran BAbdolalizadeh JBandehagh AAzadmehr AHajiaghaee R.



Melatonin could be a potential chemotherapeutic/preventive agent for malignant lymphocytes.

J Pineal Res. 2012 Nov;53(4):366-73. doi: 10.1111/j.1600-079X.2012.01006.x. Epub 2012 May 14.

Melatonin inhibits cell proliferation and induces caspase activation and apoptosis in human malignant lymphoid cell lines.

Sánchez-Hidalgo M1, Lee Mde la Lastra CAGuerrero JMPackham G.

Curcumin can inhibit growth of Hodgkin’s Lymphoma cell lines.

Cancer Growth Metastasis. 2013 Aug 8;6:35-52. doi: 10.4137/CGM.S11113. eCollection 2013.

Curcuma Contra Cancer? Curcumin and Hodgkin's Lymphoma.

Kewitz S1, Volkmer I1, Staege MS1.



Curcumin may be a therapeutic agent for patients with cutaneous T-cell Lymphoma.


J Invest Dermatol. 2010 Aug;130(8):2110-9. doi: 10.1038/jid.2010.86. Epub 2010 Apr 15.

Curcumin selectively induces apoptosis in cutaneous T-cell lymphoma cell lines and patients' PBMCs: potential role for STAT-3 and NF-kappaB signaling.

Zhang C1, Li BZhang XHazarika PAggarwal BBDuvic M.


Consumption of carotenoids might protect against Non-Hodgkin’s lymphoma development.

Ann Hematol. 2016 Dec 24. doi: 10.1007/s00277-016-2898-1. [Epub ahead of print]

Carotenoid intake and risk of non-Hodgkin lymphoma: a systematic review and dose-response meta-analysis of observational studies.

Chen F1, Hu J2, Liu P3,4, Li J1, Wei Z1, Liu P5.




Artesunate could inhibit the proliferation of B/T lymphocytic tumor cells.


Sichuan Da Xue Xue Bao Yi Xue Ban. 2009 Nov;40(6):1038-43.

[Inhibitive effect of artesunate on human lymphoblastic leukemia/lymphoma cells].

Zeng Y1, Ni X, Meng WT, Wen Q, Jia YQ.

Qinghao su has a therapeutic effect in T-cell lymphoma.


PLoS One. 2015 Oct 26;10(10):e0137331. doi: 10.1371/journal.pone.0137331. eCollection 2015.

Mechanisms of Dihydroartemisinin and Dihydroartemisinin/Holotransferrin Cytotoxicity in T-Cell Lymphoma Cells.

Wang Q1, Wu S1, Zhao X2, Zhao C1, Zhao H1, Huo L1.


Lymphoma cells are inhibited by the molecules secreted by Wharton's jelly of the human umbilical cord.


Stem Cell Rev. 2014 Aug;10(4):573-86. doi: 10.1007/s12015-014-9514-3.

Human Wharton's jelly stem cells, its conditioned medium and cell-free lysate inhibit the growth of human lymphoma cells.

Lin HD1, Fong CY, Biswas A, Choolani M, Bongso A.

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