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Lung Cancer Research

in the peer-reviewed medical literature

None of the 700+ studies listed on this site can substitute for consulting a licensed naturopathic physician.  And none can be expected to function as stand-alone, at-home treatment.

Oil from the peel of mandarin orange (Citrus reticulata Blanco cv. Dancy) possesses significant antitumor activity without being toxic.


Food Funct. 2018 Apr 25;9(4):2290-2299. doi: 10.1039/C7FO01912B. PubMed PMID: 29560978.Castro MA, Rodenak-Kladniew B, Massone A, Polo M, García de Bravo M, Crespo R.

Citrus reticulata peel oil inhibits non-small cell lung cancer cell proliferation in culture and implanted in nude mice.


The Chinese herb Taraxacum formosanum Kitam shows antitumor effects on lung cancer.


Phytomedicine. 2018 Oct 1;49:1-10. doi: 10.1016/j.phymed.2018.06.011. Epub 2018 Jun 14. PubMed PMID: 30217255.Chien JT, Chang RH, Hsieh CH, Hsu CY, Wang CC. Antioxidant property of Taraxacum formosanum Kitam and its antitumor activity in non-small-cell lung cancer cells.


Carnosic acid, a compound found in herbs such as Rosemary, Sage and Oregano, enhances the anticancer effects of cisplatin and other platinum-based drugs.


Chin J Nat Med.  Liu W, Wu TC, Hong DM, Hu Y, Fan T, Guo WJ, Xu Q.

Carnosic acid enhances the anti-lung cancer effect of cisplatin by inhibiting myeloid-derived suppressor cells. 2018 Dec;16(12):907-915. doi: 10.1016/S1875-5364(18)30132-8. PubMed PMID: 30595215.


Lemon balm (Melissa officinalis) is shown to inhibit the growth of lung cancer by inducing the death of lung cancer cells.


Food Funct.  Magalhães DB, Castro I, Lopes-Rodrigues V, Pereira JM, Barros L, Ferreira ICFR, Xavier CPR, Vasconcelos MH.

Melissa officinalis L. ethanolic extract inhibits the growth of a lung cancer cell line by interfering with the cell cycle and inducing apoptosis. 2018 Jun 20;9(6):3134-3142. doi: 10.1039/c8fo00446c. PubMed PMID: 29790547.



Seeds from plants in the Centaurea genus have a natural compound which is toxic to lung cancer cells and can induce the death of the cells.


J BUON. Mitsis M, Markopoulos G, Alexiou GA, Vartholomatos E, Lazari D, Hodaj E, Nastos D, Lianos G, Zagorianakou P, Galani V, Kyritsis AP.

Antiproliferative and cytotoxic action of N-(p-coumaroyl) serotonin in lung cancer cells. 2018 Nov-Dec;23(6):1693-1698. PubMed PMID: 30610796.


Higher Vitamin E status, was related to decreased lung cancer risk during a 28-year period.


J Natl Cancer Inst. Huang J, Weinstein SJ, Yu K, Männistö S, Albanes D. A Prospective Study of Serum Vitamin E and 28-Year Risk of Lung Cancer. 2019 May 11;. doi: 10.1093/jnci/djz077. [Epub ahead of print] PubMed PMID: 31077299.

It has been found that patients who undergo chemotherapy for non-small cell lung cancer have prolonged progression-free survival, relieved symptoms, improved quality of life and alleviated side effects if they are also treated with Chinese herbal medicine.


Front Pharmacol.  Wang Q, Jiao L, Wang S, Chen P, Bi L, Zhou D, Yao J, Li J, Chen Z, Jia Y, Zhang Z, Shen W, Zhu W, Xu J, Gao Y, Gong Y, Xu L. Maintenance Chemotherapy With Chinese Herb Medicine Formulas vs. With Placebo in Patients With Advanced Non-small Cell Lung Cancer After First-Line Chemotherapy: A Multicenter, Randomized, Double-Blind Trial. 2018;9:1233. doi: 10.3389/fphar.2018.01233. eCollection 2018. PubMed PMID: 30459612; PubMed Central PMCID: PMC6232388.


Compounds from the plant Jiaogulan (Gynostemma pentaphyllum) is toxic to lung cancer cells and inhibits the growth of lung cancer.

J Ethnopharmacol. Xing SF, Liu LH, Zu ML, Ding XF, Cui WY, Chang T, Piao XL. The inhibitory effect of gypenoside stereoisomers, gypenoside L and gypenoside LI, isolated from Gynostemma pentaphyllum on the growth of human lung cancer A549 cells. 2018 Jun 12;219:161-172. doi: 10.1016/j.jep.2018.03.012. Epub 2018 Mar 12. PubMed PMID: 29545210.

The compound β-Asarone which is found in some plants has anticancer effects and promotes the death of lung cancer cells.


Biomed Pharmacother.   Wang TL, Ouyang CS, Lin LZ. β-Asarone suppresses Wnt/β-catenin signaling to reduce viability, inhibit migration/invasion/adhesion and induce mitochondria-related apoptosis in lung cancer cells. 2018 Oct;106:821-830. doi: 10.1016/j.biopha.2018.07.009. Epub 2018 Jul 11. PubMed PMID: 29990876.


The plant Alnus nitida is shown to have potent anti-lung cancer effects.


Biomed Pharmacother.   Sajid M, Yan C, Li D, Merugu SB, Negi H, Khan MR. Potent anti-cancer activity of Alnus nitida against lung cancer cells; in vitro and in vivo studies. 2019 Feb;110:254-264. doi: 10.1016/j.biopha.2018.11.138. Epub 2018 Dec 1. PubMed PMID: 30508737.


Oridonin a compound extracted from medicinal herbs enhances the ability of radiation treatment to induce the death of non-small cell lung cancer cells.


Int J Mol Sci.   Park H, Jeong YJ, Han NK, Kim JS, Lee HJ. Oridonin Enhances Radiation-Induced Cell Death by Promoting DNA Damage in Non-Small Cell Lung Cancer Cells. 2018 Aug 13;19(8). doi: 10.3390/ijms19082378. PubMed PMID: 30104472; PubMed Central PMCID: PMC6121891.


Compounds from the seeds of Podocarpus nagi suppresses the ability of non-small cell cancer cells to spread.

Phytomedicine.   Zhang LL, Jiang XM, Huang MY, Feng ZL, Chen X, Wang Y, Li H, Li A, Lin LG, Lu JJ. Nagilactone E suppresses TGF-β1-induced epithelial-mesenchymal transition, migration and invasion in non-small cell lung cancer cells. 2019 Jan;52:32-39. doi: 10.1016/j.phymed.2018.09.222. Epub 2018 Sep 26. PubMed PMID: 30599910.

Gambogic acid a compound made from the Garcinia hanburyi tree inhibits the growth of lung cancer.


J Cancer Res Ther.  Ye L, Zhou J, Zhao W, Jiao P, Ren G, Wang S. Gambogic acid-induced autophagy in non-small cell lung cancer NCI-H441 cells through a reactive oxygen species pathway. 2018 Dec;14(Supplement):S942-S947. doi: 10.4103/0973-1482.206866. PubMed PMID: 30539827.

Ethyl Acetate Extract of Scindapsus cf. hederaceus is a potential treatment of lung cancer.


Int J Mol Sci.  Chou CK, Liu W, Hong YJ, Dahms HU, Chiu CH, Chang WT, Chien CM, Yen CH, Cheng YB, Chiu CC. Ethyl Acetate Extract of Scindapsus cf. hederaceus Exerts the Inhibitory Bioactivity on Human Non-Small Cell Lung Cancer Cells through Modulating ER Stress. 2018 Jun 21;19(7). doi: 10.3390/ijms19071832. PubMed PMID: 29933620; PubMed Central PMCID: PMC6073426.


Water extract of Arthrospira platensis from the dietary supplement Spirulina shows anti-cancer activity against lung cancer cells. Showing that the product Spirulina may be an effective cancer treatment.


Biomed Pharmacother.   Czerwonka A, Kaławaj K, Sławińska-Brych A, Lemieszek MK, Bartnik M, Wojtanowski KK, Zdzisińska B, Rzeski W. Anticancer effect of the water extract of a commercial Spirulina (Arthrospira platensis) product on the human lung cancer A549 cell line. 2018 Oct;106:292-302. doi: 10.1016/j.biopha.2018.06.116. Epub 2018 Jun 28. PubMed PMID: 29966973.


Evidence suggests that Disodium cantharidinate and Vitamin B6 injection combined with chemotherapy could improve clinical symptoms, and reduce side effects caused by chemotherapy in patients with non-small cell lung cancer.


Evid Based Complement Alternat Med.  Wang Z, Feng F, Wu Q, Jin Y, Gu C, Xu Y, Zhou X, He H. Disodium Cantharidinate and Vitamin B6 Injection Adjunct with Platinum-Based Chemotherapy for the Treatment of Advanced Non-Small-Cell Lung Cancer: A Meta-Analysis. 2019;2019:9386273. doi: 10.1155/2019/9386273. eCollection 2019. Review. PubMed PMID: 30992710; PubMed Central PMCID: PMC6434307.



Vitamin D supplementation is effective in improving lung function and reducing asthma risk in current/former smokers. 


Nutrients.  Alsharairi NA. The Effects of Dietary Supplements on Asthma and Lung Cancer Risk in Smokers and Non-Smokers: A Review of the Literature. . 2019 Mar 28;11(4). doi: 10.3390/nu11040725. Review. PubMed PMID: 30925812; PubMed Central PMCID: PMC6521315.


Extract from Marsdenia tenacissima is shown to cause the death of lung cancer cells.


Cancer Cell Int    Jiao YN, Wu LN, Xue D, Liu XJ, Tian ZH, Jiang ST, Han SY, Li PP. Marsdenia tenacissimaextract induces apoptosis and suppresses autophagy through ERK activation in lung cancer cells. . 2018;18:149. doi: 10.1186/s12935-018-0646-4. eCollection 2018. PubMed PMID: 30275772; PubMed Central PMCID: PMC6161462. 


Extract from the tree Bulnesia sarmientoi can cause lung cancer cells to die from inflammation, it also lessens the likelihood of the cancer spreading.


Molecules.  Wang HL, Chang JC, Fang LW, Hsu HF, Lee LC, Yang JF, Liang MT, Hsiao PC, Wang CP, Wang SW, Chang CC, Houng JY. Bulnesia sarmientoi Supercritical Fluid Extract Exhibits Necroptotic Effects and Anti-Metastatic Activity on Lung Cancer Cells. 2018 Dec 13;23(12). doi: 10.3390/molecules23123304. PubMed PMID: 30551590; PubMed Central PMCID: PMC6320997.


Brucea javanica oil mixture can inhibit the growth and potential to spread of non-small cell lung cancer.


Zhong Nan Da Xue Xue Bao Yi Xue Ban   Zhu X, Pan P. [Effect of Brucea javanica oil emulsion on proliferation, migration and autophagy of non-small cell lung cancer A549 cells and the underlying mechanisms].. 2018 Nov 28;43(11):1202-1208. doi: 10.11817/j.issn.1672-7347.2018.11.006. PubMed PMID: 30643064.


The plant Asian water plantain (Alisma orientale) induces lung cancer cell death.


Biochem Biophys Res Commun.  Wang J, Li H, Wang X, Shen T, Wang S, Ren D. Alisol B-23-acetate, a tetracyclic triterpenoid isolated from Alisma orientale, induces apoptosis in human lung cancer cells via the mitochondrial pathway. 2018 Nov 10;505(4):1015-1021. doi: 10.1016/j.bbrc.2018.10.022. Epub 2018 Oct 9. PubMed PMID: 30314700.

The evergreen Selaginella tamariscina may inhibit the spread of lung cancer to other areas of the body.


Bioorg Med Chem Lett.  Wang CG, Yao WN, Zhang B, Hua J, Liang D, Wang HS. Lung cancer and matrix metalloproteinases inhibitors of polyphenols from Selaginella tamariscina with suppression activity of migration. 2018 Aug 1;28(14):2413-2417. doi: 10.1016/j.bmcl.2018.06.024. Epub 2018 Jun 18. PubMed PMID: 29921475.


A compound from Alpinia nantonensis shows the ability to inhibit the spread of lung cancer tumors.


Phytomedicine.  Kumar KJS, Wang SH, Tseng YH, Tsao NW, Kuo YH, Wang SY. trans-3-Methoxy-5-hydroxystilbene (MHS) from the rhizome of Alpinia nantonensis inhibits metastasis in human lung cancer cells. 2018 Nov 15;50:223-230. doi: 10.1016/j.phymed.2018.04.010. Epub 2018 Apr 5. PubMed PMID: 30466982.


A fluid produced by the European Nightcrawler (Dendrobaena veneta) is shown to be toxic to certain lung cancer cells and shows promise to develop a cancer treatment.


APMIS.  Fiołka MJ, Rzymowska J, Bilska S, Lewtak K, Dmoszyńska-Graniczka M, Grzywnowicz K, Kaźmierski W, Urbanik-Sypniewska T. Antitumor activity and apoptotic action of coelomic fluid from the earthworm Dendrobaena veneta against A549 human lung cancer cells. 2019 Jun;127(6):435-448. doi: 10.1111/apm.12941. Epub 2019 Mar 28. PubMed PMID: 30803036.


The plant Gelidiella acerosa inhibits the spread of non-small cell lung cancer.

BMC Complement Altern Med.  S M FMB, Chitra K, Joseph B, Sundararajan R, S H. Gelidiella acerosa inhibits lung cancer proliferation. 2018 Mar 20;18(1):104. doi: 10.1186/s12906-018-2165-1. PubMed PMID: 29558998; PubMed Central PMCID: PMC5861612.

BJ-1207, a derivative of vitamin B6 inhibited the growth of lung cancer cells as well as or better than the frequently used chemotherapy drugs: sunitinib and cisplatin though the study was not conducted with on human cells.

Chem Biol Interact.  Gautam J, Banskota S, Chaudhary P, Dahal S, Kim DG, Kang HE, Lee IH, Nam TG, Jeong BS, Kim JA. Antitumor activity of BJ-1207, a 6-amino-2,4,5-trimethylpyridin-3-ol derivative, in human lung cancer. 2018 Oct 1;294:1-8. doi: 10.1016/j.cbi.2018.08.007. Epub 2018 Aug 17. PubMed PMID: 30125546.

A compound derived from Descurainia sophia shows potent anti-tumor activity and low toxicity towards other cells.


Nan Fang Yi Ke Da Xue Xue Bao.  Gui J, Zhu M, Bai X, Li B, Gao M, Ma H, Li H, Wu C. [Effect of methanol-ethyl acetate partitioned fractions from Descurainia sophia on proliferation and apoptosis of human non-small cell lung cancer H1975 cells]. 2019 Feb 28;39(2):169-174. doi: 10.12122/j.issn.1673-4254.2019.02.07. PubMed PMID: 30890504.


A compound from the flower buds of Coltsfoot (Tussilago farfara) is shown to reduce the spread of non-small cell lung cancer and promote the death of non-small cell lung cancer cells.


Int J Biol Macromol.   Qu H, Yang W, Li J. Structural characterization of a polysaccharide from the flower buds of Tussilago farfara, and its effect on proliferation and apoptosis of A549 human non-small lung cancer cell line. 2018 Jul 1;113:849-858. doi: 10.1016/j.ijbiomac.2018.03.005. Epub 2018 Mar 2. PubMed PMID: 29505876.



The evergreen Arbor-vitae (Thuja orientalis) is shown to exhibit anti-lung cancer properties.


Biomed Pharmacother.   R EB, Jesubatham PD, V M BG, S V, S S. Non-toxic and non teratogenic extract of Thuja orientalis L. inhibited angiogenesis in zebra fish and suppressed the growth of human lung cancer cell line. 2018 Oct;106:699-706. doi: 10.1016/j.biopha.2018.07.010. Epub 2018 Jul 11. PubMed PMID: 29990861.


Dried leaves of Sweet Wormwood (Artemisia annua) promotes the death of non-small cell lung cancer cells and inhibits the cancer from spreading.


Phytomedicine.    Rassias DJ, Weathers PJ. Dried leaf Artemisia annua efficacy against non-small cell lung cancer. 2019 Jan;52:247-253. doi: 10.1016/j.phymed.2018.09.167. Epub 2018 Sep 20. PubMed PMID: 30599905.

Pleurodesis with Mistletoe (Viscus album) extract is shown to be an effective and tolerable procedure for controlling malignant pleural effusion in lung cancer patients.

Support Care Cancer  Lee YG, Jung I, Koo DH, Kang DY, Oh TY, Oh S, Lee SS. Efficacy and safety of Viscum album extract (Helixor-M) to treat malignant pleural effusion in patients with lung cancer. 2019 May;27(5):1945-1949. doi: 10.1007/s00520-018-4455-z. Epub 2018 Sep 14. PubMed PMID: 30218188.


The plant Houttuynia cordata is shown to stop the spread of lung cancer cells by stopping their function and killing them.


Int J Biol Macromol.   Han K, Jin C, Chen H, Wang P, Yu M, Ding K. Structural characterization and anti-A549 lung cancer cells bioactivity of a polysaccharide from Houttuynia cordata. 2018 Dec;120(Pt A):288-296. doi: 10.1016/j.ijbiomac.2018.08.061. Epub 2018 Aug 14. PubMed PMID: 30114425.

Lingzhi mushroom (Ganoderma lucidum) shows anti-tumor results and is a potential lung cancer treatment.


Drug Deliv.   Guo J, Yuan C, Huang M, Liu Y, Chen Y, Liu C, Chen Y. Ganoderma lucidum-derived polysaccharide enhances coix oil-based microemulsion on stability and lung cancer-targeted therapy. 2018 Nov;25(1):1802-1810. doi: 10.1080/10717544.2018.1516006. PubMed PMID: 30343605; PubMed Central PMCID: PMC6201799.


The roots of the flowering plant Scutellaria baicalensis known as Scutellaria Radix promotes the death of lung cancer cells.


Am J Chin Med.   Kim HI, Hong SH, Ku JM, Lim YS, Lee SJ, Song J, Kim TY, Cheon C, Ko SG. Scutellaria Radix Promotes Apoptosis in Non-Small Cell Lung Cancer Cells via Induction of AMPK-Dependent Autophagy. 2019;47(3):691-705. doi: 10.1142/S0192415X19500368. Epub 2019 Apr 11. PubMed PMID: 30974965.

The plant Chinese Cassia (Cinnamomum cassia) shows antitumor properties and promotes the death of lung cancer cells.


J Pharmacol Sci.   Lee EJ, Chung TW, Lee JH, Kim BS, Kim EY, Lee SO, Ha KT. Water-extracted branch of Cinnamomum cassia promotes lung cancer cell apoptosis by inhibiting pyruvate dehydrogenase kinase activity. 2018 Oct;138(2):146-154. doi: 10.1016/j.jphs.2018.10.005. Epub 2018 Oct 18. PubMed PMID: 30392804.


Panaxydol a compound derived from Asian Ginseng is shown to oppose the growth of non-small cell lung cancer.


Biol Pharm Bull.  Lee JH, Leem DG, Chung KS, Kim KT, Choi SY, Lee KT. Panaxydol Derived from Panax ginseng Inhibits G1 Cell Cycle Progression in Non-small Cell Lung Cancer via Upregulation of Intracellular Ca2+ Levels. 2018;41(11):1701-1707. doi: 10.1248/bpb.b18-00447. PubMed PMID: 30381670.


A compound from the plant Alpinia officinarum significantly suppresses lung cancer cell growth without obvious toxicity to the liver.


Food Funct.  Li N, Zhang Q, Jia Z, Yang X, Zhang H, Luo H. Volatile oil from alpinia officinarum promotes lung cancer regression in vitro and in vivo. 2018 Sep 19;9(9):4998-5006. doi: 10.1039/c8fo01151f. PubMed PMID: 30187896.


Curcumin, a popular supplement and a compound found in the root of turmeric, is shown to inhibit lung cancer growth in mice.


Oncol Lett.   Li X, Ma S, Yang P, Sun B, Zhang Y, Sun Y, Hao M, Mou R, Jia Y. Anticancer effects of curcumin on nude mice bearing lung cancer A549 cell subsets SP and NSP cells. 2018 Nov;16(5):6756-6762. doi: 10.3892/ol.2018.9488. Epub 2018 Sep 24. PubMed PMID: 30405819; PubMed Central PMCID: 30405819.   PMC6202465.


The Chinese herbal medicine Mai-Men-Dong-Tang exerts anticancer effects such as inducing the death of lung cancer cells.


Phytomedicine.   Lin YJ, Liang WM, Chen CJ, Tsang H, Chiou JS, Liu X, Cheng CF, Lin TH, Liao CC, Huang SM, Chen J, Tsai FJ, Li TM. Network analysis and mechanisms of action of Chinese herb-related natural compounds in lung cancer cells. 2019 May;58:152893. doi: 10.1016/j.phymed.2019.152893. Epub 2019 Mar 13. PubMed PMID: 30901663.


The twigs of Casearia kurzii have shown toxic activities towards lung cancer cells.


Bioorg Chem.  Liu F, Zhang Q, Yang X, Xi Y, Zhang X, Wang H, Zhang J, Tuerhong M, Jin DQ, Lee D, Xu J, Ohizumi Y, Shuai L, Guo Y. Cytotoxic diterpenoids as potential anticancer agents from the twigs of Casearia kurzii. 2019 May 23;89:102995. doi: 10.1016/j.bioorg.2019.102995. [Epub ahead of print] PubMed PMID: 31185389.


The Asian plant Scutellaria barbata, a member of the mint family, effectively inhibits non-small cell lung cancer tumor growth.


Front Pharmacol.   Liu J, Jiang M, Li Z, Zhang X, Li X, Hao Y, Su X, Zhu J, Zheng C, Xiao W, Wang Y. A NovelSystems Pharmacology Method to Investigate Molecular Mechanisms of Scutellaria barbata D. Don for Non-small Cell Lung Cancer. 2018;9:1473. doi: 10.3389/fphar.2018.01473. eCollection 2018. PubMed PMID: 30618763; PubMed Central PMCID: PMC6304355.

Two herbal medicines, Coptidis rhizoma (CR) and Curcumae longae rhizoma (CLR), were found to induce the synergistic effects of cancer fighting cytotoxins in lung cancer cells


Pharmacogn Mag. 2018 Apr-Jun;14(54):145-148. doi: 10.4103/pm.pm_270_17. Epub 2018 Apr 10.

Herbal Medicines Showing Synergistic Effects with Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) against A549 TRAIL-resistant Lung Cancer Cells: A Screening Study.

Chiang SCChoi YJKang SEYun MLee BJ.



Baicalin, a flavonoid derived from Scutellaria baicalensis, was found to inhibit the proliferation and migration of human non-small cell lung cancer cells.


Med Sci Monit. 2018 Apr 10;24:2126-2133.

Baicalin, a Chinese Herbal Medicine, Inhibits the Proliferation and Migration of Human Non-Small Cell Lung Carcinoma (NSCLC) Cells, A549 and H1299, by Activating the SIRT1/AMPK Signaling Pathway.

You JCheng JYu BDuan CPeng J.



Baicalin was found to inhibit the proliferation activity in non-small cell lung cancer cells


Cancer Biomark. 2018 Mar 23. doi: 10.3233/CBM-170673. [Epub ahead of print]

Baicalein suppresses non small cell lung cancer cell proliferation, invasion and Notch signaling pathway.

Su GChen HSun X.


A traditional Chinese herbal medicine formula, Bu-Fei decoction may inhibit the growth of non‑small cell lung cancer


Int J Mol Med. 2018 Apr;41(4):2128-2138. doi: 10.3892/ijmm.2018.3444. Epub 2018 Jan 30.

Bu-Fei decoction and modified Bu-Fei decoction inhibit the growth of non-small cell lung cancer, possibly via inhibition of apurinic/apyrimidinic endonuclease 1.

Jiang STHan SYPang LNJiao YNHe XRLi PP.


An herbal medicine isolate, Jolkinolide B, can inhibit growth in non-small cell lung cancer cells.


J Cell Biochem. 2018 Jun;119(6):4967-4974. doi: 10.1002/jcb.26742. Epub 2018 Mar 9.

Jolkinolide B inhibits glycolysis by downregulating hexokinase 2 expression through inactivating the Akt/mTOR pathway in non-small cell lung cancer cells.

Gao XHan H.



Scutellaria barbata D. Don (SB), which is derived from the dried whole plant of Labiatae, was found to reduce lung cancer tumor size.


Oncotarget. 2017 Nov 27;8(65):109340-109357. doi: 10.18632/oncotarget.22677. eCollection 2017 Dec 12.

The anti-cancer effects and mechanisms of Scutellaria barbata D. Don on CL1-5 lung cancer cells.

Chen CCKao CPChiu MMWang SH.


An herbal medicine, Camptosorus sibiricus Rupr was found to prevent lung tumorigenesis


J Ethnopharmacol. 2017 Dec 16;220:44-56. doi: 10.1016/j.jep.2017.12.021. [Epub ahead of print]

Camptosorus sibiricus rupr aqueous extract prevents lung tumorigenesis via dual effects against ROS and DNA damage.

He SOu RWang WJi LGao HZhu YLiu XZheng HLiu ZWu PLu L.



An herbal blend of Oldenlandia diffusa and Salvia miltiorrhiza extract was found to exert antiangiogenic and apoptotic effects on non-small cell lung cancer cells.


Oncotarget. 2017 Oct 19;8(60):101771-101783. doi: 10.18632/oncotarget.21973. eCollection 2017 Nov 24.

Inhibition of STAT3/VEGF/CDK2 axis signaling is critically involved in the antiangiogenic and apoptotic effects of arsenic herbal mixture PROS in non-small lung cancer cells.

Lee HLee HJBae IJKim JJKim SH.



A component of the plant, Hydrastis canadensis, has been found to be effective at suppressing proliferation of human lung cancer cells.


Oncol Rep. 2016 Apr;35(4):2246-56. doi: 10.3892/or.2016.4594. Epub 2016 Jan 25.

(-)-β-hydrastine suppresses the proliferation and invasion of human lung adenocarcinoma cells by inhibiting PAK4 kinase activity.

Guo B1, Li X1, Song S2, Chen M1, Cheng M2, Zhao D2, Li F1.



Flax Seed Oil has a protective role against lung cancer metastasis.


J BUON. 2015 Nov-Dec;20(6):1546-52.

Flax seed oil inhibits metastatic melanoma and reduces lung tumor formation.

Han J1, Lu SSWang ZJLi YL.


Higher dietary vitamin E intake exerts a protective effect against lung cancer.


Asia Pac J Clin Nutr. 2017 Mar;26(2):271-277. doi: 10.6133/apjcn.032016.04.

Association of dietary vitamin E intake with risk of lung cancer: a dose-response meta-analysis.

Zhu YJ1, Bo YC2, Liu XX2, Qiu CG3.



Grape Seed extract has an anti-neoplastic and chemopreventive agent for lung cancer.


J Nutr Biochem. 2016 Aug;34:118-25. doi: 10.1016/j.jnutbio.2016.05.003. Epub 2016 May 20.

MicroRNA-19a/b mediates grape seed procyanidin extract-induced anti-neoplastic effects against lung cancer.

Mao JT1, Xue B2, Smoake J2, Lu QY3, Park H2, Henning SM3, Burns W4, Bernabei A5, Elashoff D6, Serio KJ7, Massie L4.


Scutellaria baicalensis Georgi may be a useful chemotherapeutic agent for lung cancer.


J Ethnopharmacol. 2011 Jan 27;133(2):634-41. doi: 10.1016/j.jep.2010.10.057. Epub 2010 Nov 10.

Korean Scutellaria baicalensis water extract inhibits cell cycle G1/S transition by suppressing cyclin D1 expression and matrix-metalloproteinase-2 activity in human lung cancer cells.

Park KI1, Park HSKang SRNagappan ALee DHKim JAHan DYKim GS.

Astragalus might be a potential chemo-preventive drug for lung cancer therapy.


Int J Clin Exp Pathol. 2014 Dec 1;7(12):8453-61. eCollection 2014.

Formononetin suppresses the proliferation of human non-small cell lung cancer through induction of cell cycle arrest and apoptosis.

Yang Y1, Zhao Y1, Ai X1, Cheng B1, Lu S1.


This review summarizes and stratifies pre-clinical evidence for chemo-preventive efficacy of Curcumin in models of lung cancer.


J Pharmacol Exp Ther. 2014 Sep;350(3):483-94. doi: 10.1124/jpet.114.216333. Epub 2014 Jun 17

Translating curcumin to the clinic for lung cancer prevention: evaluation of the preclinical evidence for its utility in primary, secondary, and tertiary prevention strategies.

Howells LM1, Mahale J2, Sale S2, McVeigh L2, Steward WP2, Thomas A2, Brown K2.


Scutellaria baicalensis and its active compounds induce cell cycle arrest in human lung cancer cells.

Toxicol Appl Pharmacol. 2011 Aug 1;254(3):221-8. doi: 10.1016/j.taap.2011.03.016. Epub 2011 Mar 30.

The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells.

Gao J1, Morgan WASanchez-Medina ACorcoran O.


Andrographolide down-regulates hypoxia-inducible factor in human non-small cell lung cancer cells.


Toxicol Appl Pharmacol. 2011 Feb 1;250(3):336-45. doi: 10.1016/j.taap.2010.11.014. Epub 2010 Dec 4.

Andrographolide down-regulates hypoxia-inducible factor-1α in human non-small cell lung cancer A549 cells.

Lin HH1, Tsai CWChou FPWang CJHsuan SWWang CKChen JH.


Jobi seed extract hold promise as an efficient drug delivery system for the treatment of lung cancer.

Int J Nanomedicine. 2014;9:109-19. doi: 10.2147/IJN.S54796. Epub 2013 Dec 19.

Triterpene-loaded microemulsion using Coix lacryma-jobi seed extract as oil phase for enhanced antitumor efficacy: preparation and in vivo evaluation.

Qu D1, He J1, Liu C1, Zhou J1, Chen Y1.


Curcumin could be an important potential adjuvant therapeutic agent for lung cancer.


PLoS One. 2015 Dec 10;10(12):e0144462. doi: 10.1371/journal.pone.0144462. eCollection 2015.

Curcumin Inhibits Non-Small Cell Lung Cancer Cells Metastasis through the Adiponectin/NF-κb/MMPs Signaling Pathway.

Tsai JR1,2, Liu PL1, Chen YH3, Chou SH1,4, Cheng YJ5, Hwang JJ1,2, Chong IW1.



Curcumin has anti-cancer effects and shows inhibition of migration and invasion in lung cancer cells.

Cancer Lett. 2009 Nov 28;285(2):127-33. doi: 10.1016/j.canlet.2009.04.037. Epub 2009 May 23.

Curcumin inhibits the migration and invasion of human A549 lung cancer cells through the inhibition of matrix metalloproteinase-2 and -9 and Vascular Endothelial Growth Factor (VEGF).

Lin SS1, Lai KCHsu SCYang JSKuo CLLin JPMa YSWu CCChung JG.


The traditional Chinese medicine Astragalus might reverse Th2 predominant status in lung cancer patients.

Oncol Rep. 2003 Sep-Oct;10(5):1507-12.

Traditional Chinese medicine Astragalus reverses predominance of Th2 cytokines and their up-stream transcript factors in lung cancer patients.

Wei H1, Sun RXiao WFeng JZhen CXu XTian Z.


Ginger extract might prove to be beneficial as a complementary agent in lung cancer prevention and maintenance therapy.


J Med Food. 2010 Dec;13(6):1347-54. doi: 10.1089/jmf.2010.1191.

Ginger extract inhibits human telomerase reverse transcriptase and c-Myc expression in A549 lung cancer cells.

Tuntiwechapikul W1, Taka TSongsomboon CKaewtunjai NImsumran AMakonkawkeyoon LPompimon WLee TR.



This study revealed that Bergamottin (A grapefruit juice extract) was able to inhibit lung cancer cell growth.

Oncol Rep. 2016 Jul;36(1):324-32. doi: 10.3892/or.2016.4833. Epub 2016 May 23.

Bergamottin isolated from Citrus bergamia exerts in vitro and in vivo antitumor activity in lung adenocarcinoma through the induction of apoptosis, cell cycle arrest, mitochondrial membrane potential loss and inhibition of cell migration and invasion.

Wu HJ1, Wu HB1, Zhao YQ1, Chen LJ1, Zou HZ1.


Croton tiglium extract can inhibit proliferation of lung cancer cells.


Asian Pac J Cancer Prev. 2016 Nov 1;17(11):4893-4898.

Croton Tiglium Extract Induces Apoptosis via Bax/Bcl-2 Pathways in Human Lung Cancer A549 Cells

Li Ch1, Wu XSun RZhao PLiu FZhang Ch.


Withania somnifera/ Acnistus arborescens can inhibit proliferation and induce apoptosis of lung cancer cells.


Asian Pac J Cancer Prev. 2014;15(4):1711-4.

Effect of Withaferin A on A549 cellular proliferation and apoptosis in non-small cell lung cancer.

Cai Y1, Sheng ZYChen YBai C.

Feiliuping ointment has a significant anti-tumor effect


Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010 Dec;30(12):1288-91.

[Effect of feiliuping ointment and its disassembled prescriptions on dendritic cell of mice with transplanted Lewis lung cancer].

Zheng HG1, Piao BKHua BJ.


This study shows that Safflower suppresses tumor growth in non-small cell lung cancer.


Oncol Rep. 2016 Jul;36(1):147-54. doi: 10.3892/or.2016.4784. Epub 2016 May 4.

Safflower polysaccharide induces NSCLC cell apoptosis by inhibition of the Akt pathway.

Li JY1, Yu J2, Du XS3, Zhang HM3, Wang B3, Guo H3, Bai J3, Wang JH4, Liu A3, Wang YL1.

These findings provide an insightful approach to the anticancer effect of Triptolide, the major bioactive component isolated from the Chinese Medicinal plant Tripterygium wilfordii, against lung cancer cells.


Biomed Pharmacother2018 Jul;103:1557-1566. doi: 10.1016/j.biopha.2018.04.198. Epub 2018 May 7.

Biochemical and computational evaluation of Triptolide-induced cytotoxicity against NSCLC.

Hamdi AMJiang ZZGuerram MYousef BAHassan HMLing JWZhang LY.

Hedyotis diffusa, an herb used in Chinese medicine, induces the death of lung cancer cells.

Lin L, Cheng K, Xie Z, Chen C, Chen L, Huang Y, Liang Z.


Int J Biol Macromol  2019 Feb 1;122:64-71. doi: 10.1016/j.ijbiomac.2018.10.077. Epub 2018 Oct 18. PubMed PMID: 30342944.

Purification and characterization a polysaccharide from Hedyotis diffusa and its apoptosis inducing activity toward human lung cancer cell line A549. 

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