Cervical and Uterine

Cancer Research

in the peer-reviewed medical literature

None of the 700+ studies listed on this site can substitute for consulting a licensed naturopathic physician.  And none can be expected to function as stand-alone, at-home treatment.

Vitamin C / ascorbate cancelled tumorigenic effect of estrogen promotion of uterine cancer.

Vopr Onkol. 1990;36(5):563-7.

[The inhibitory effect of ascorbic acid on the estrogen-stimulated promotion of uterine sarcoma development in mice].

[Article in Russian]

Trukhanova LSParfenov IuDTurusov VS.

Selenium exposure might be a protective factor for cervical cancer.

 

Biol Trace Elem Res. 2017 Mar 2. doi: 10.1007/s12011-017-0982-6. [Epub ahead of print]

Serum Selenium Levels and Cervical Cancer: Systematic Review and Meta-Analysis.

He D1,2, Wang Z1,2, Huang C1,2, Fang X1,2, Chen D3,4.

 

Effects of Curcumin were found to suppress proliferation of and induced the apoptosis in human cervical epithelioid carcinoma cancer cells.

 

Int J Nanomedicine. 2017 Nov 29;12:8545-8556. doi: 10.2147/IJN.S146516. eCollection 2017.

Induction of apoptosis in HeLa cancer cells by an ultrasonic-mediated synthesis of curcumin-loaded chitosan-alginate-STPP nanoparticles.

Ahmadi FGhasemi-Kasman MGhasemi SGholamitabar Tabari MPourbagher RKazemi SAlinejad-Mir A.

 

Matrine was found to inhibit cervical cancer cell growth.

 

Oncol Rep. 2017 Aug;38(2):1312-1320. doi: 10.3892/or.2017.5787. Epub 2017 Jul 3.

Matrine inhibits the metastatic properties of human cervical cancer cells via downregulating the p38 signaling pathway.

Wu XZhou JCai DLi M.

 

Rikkonshito was found to help prevent nausea and vomiting in chemotherapy treated patients with cervical cancer.

 

J Gynecol Oncol. 2017 Sep;28(5):e44. doi: 10.3802/jgo.2017.28.e44. Epub 2017 Mar 17.

Additive effect of rikkunshito, an herbal medicine, on chemotherapy-induced nausea, vomiting, and anorexia in uterine cervical or corpus cancer patients treated with cisplatin and paclitaxel: results of a randomized phase II study (JORTC KMP-02).

Ohnishi SWatari HKanno MOhba YTakeuchi SMiyaji TOyamada SNomura EKato HSugiyama TAsaka MSakuragi NYamaguchi TUezono YIwase S.

 

 

 

Caesalpinia sappan, Curcuma comosa and Mammea siamensis were strikingly active against ovarian and cervical cancer cells. 

 

J Med Assoc Thai. 2014 Aug;97 Suppl 8:S149-55.

In vitro cytotoxic activity of Sa-Tri-Lhung-Klod remedy and its herbal ingredients on ovarian and cervical carcinoma cell lines.

Inprasit JRuangnoo SItharat A.

 

Acacia Falcata extract has significant antiproliferative effect in cervical HeLa cancer cells

 

J BUON. 2015 Nov-Dec;20(6):1487-96.

Antiproliferative and apoptotic effects of the ethanolic herbal extract of Achillea falcata in human cervical cancer cells are mediated via cell cycle arrest and mitochondrial membrane potential loss.

Tian Q1, Zang YH.

Ginger and turmeric kill cervical cancer cells in test tubes, showing promise as a treatment for cervical cancer.

 

Scientific World J.  Assessment of Cytotoxic Activity of Rosemary (Rosmarinus officinalis L.), Turmeric (Curcuma longa L.), and Ginger (Zingiber officinale R.) Essential Oils in Cervical Cancer Cells (HeLa).

Santos PA1, Avanço GB1, Nerilo SB2, Marcelino RI3, Janeiro V4, Valadares MC3, Machinski M1.

A specific nutrient mixture has shown anticancer effects on multidrug-resistant uterine sarcoma.

Oncol Rep. 2012 Jan;27(1):17-27. doi: 10.3892/or.2011.1471. Epub 2011 Sep 22.

Anticancer effects of a specific mixture of nutrients in the multidrug-resistant human uterine sarcoma MES-SA/Dx5 and the drug-sensitive MES-SA cell lines.

Roomi MW1, Kalinovsky T, Roomi NW, Rath M, Niedzwiecki A.

Nutrient mixture (NM) containing lysine, ascorbic acid, proline, green tea extract and other micronutrients strongly inhibit cervical tumor growth and cancer markers.

 

Exp Ther Med. 2015 Feb;9(2):294-302. Epub 2014 Dec 11.

Effects of a nutrient mixture on immunohistochemical localization of cancer markers in human cervical cancer HeLa cell tumor xenografts in female nude mice.

Roomi MW1, Kalinovsky T1, Cha J1, Roomi NW1, Niedzwiecki A1, Rath M1

Astragalus shows its anti-tumor effect in cervical cancer.

 

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010 Nov;30(11):1157-9.

[Regulatory effect of astragalus injection on Th1/Th2 cell function in patients with cervical cancer].

Hu YJ1, Li LGong SX.

Hyperthermia is a well-documented alternative and complementary cancer treatment. There were fewer recurrences (18% vs. 53%) and better 5-year survival (52% vs. 17%) for cervical cancer patients who receive hyperthermia less than two hours following radiotherapy in patients not doing chemotherapy. Toxicity levels were not significantly different for women having hyperthermia more than two hours after radiotherapy.  The majority of DNA repair occurs within 2 hours, which might explain the difference in the timing intervals.

 

Radiat Oncol. 2017 Apr 27;12(1):75. doi: 10.1186/s13014-017-0813-0.

A short time interval between radiotherapy and hyperthermia reduces in-field recurrence and mortality in women with advanced cervical cancer.

van Leeuwen CM1, Oei AL2,3, Chin KWTK4, Crezee J4, Bel A4, Westermann AM5, Buist MR6, Franken NAP4,7, Stalpers LJA4, Kok HP4.

 

 

This article is written in Bulgarian. However the abstract says it is being studied to reverse early stages of cervical cancer and risk factors of recurring HPV. Coriolus versicolor is derived from a mushroom commonly known as turkey tail. It is prized in Chinese Medicine for fighting cancer. It is grown in many locations throughout the world.

 

Akush Ginekol (Sofiia). 2008;47 Suppl 3:51-3.

[Coriolus versicolor--innovation in prevention of oncogynecological diseases, especially HPV].

Bogdanova J.

 

Ganoderic Mf and Ganodercid GA-S are both derived from Ganoderma luidum (the Reishi mushroom) and play a big part in Chinese medicine. HeLa cells are a type of cell in a mortal cell line used in research. They were derived from cervical cells taken from a patient, who died of her disease in 1951. Mitochondria are responsible for biochemical processes inside cells. One way apoptosis (cell death) happens is through a biological process carried out by mitochondria in this case after being exposed to GA-Mf and GA-S. 

 

Phytomedicine. 2011 Mar 15;18(5):349-55. doi: 10.1016/j.phymed.2010.08.019. Epub 2010 Oct 29.

Ganoderic acid Mf and S induce mitochondria mediated apoptosis in human cervical carcinoma HeLa cells.

Liu RMZhitong JJ.

 

 

[Article in Japanese] Abstract says this study compared the effects on uterine cervix of radiation with and without PSK. PSK is derived from Coriolus versicolor from a particular kind of mushroom used in Chinese and Japanese medicine to treat cancer with good results. In this study PSK was found to have a beneficial effect on giant cells (over 4 C) caused by endomitosis (a doubling of chromosomes) and in cases that are resistant to radiotherapy. Other studies show other anti-cancer effects.

 

Nihon Sanka Fujinka Gakkai Zasshi. 1988 Feb;40(2);179-86

Enhancing effect of irradiation on carcinoma of the uterine cervix by administering the protein-bound polysaccharide kureha (PSK) - - quantitative nuclear analysis following irradiation.

Hayashi Y.

 

 

Pronounced longer-term survival for patients administered PS-K for uterine cancer. Five year survival for stage IIIb was 65% vs. 49% for the control group. PS-K showed an early effect for 37% of patients.

 

Gan No Rinsho. 1986 Feb;32(2):181-5.

[The effects of PS-K on long-term survival of uterine cervical cancer patients treated with radiation].

Okazaki AMitsuhashi NYamakawa MNozaki MTakeuchi MNiibe H.

 

 

PS-K significantly enhanced the effect of radiation for patients with uterine cancer.

 

Nihon Sanka Fujinka Gakkai Zasshi. 1985 Sept;37(9);1908-14.

[Enhancement of irradiation effect in carcinoma of the uterine cervix with the administration of protein-bound polysaccharide kureha (PS-K)].

Kazuta M.

 

 

Apigenin, a plant flavone found in artichokes, parsley, celery, chamomile tea, Italian herbs, and some fruits, has the ability to kill cervical cancer cell lines induced by HPV genotypes.  

 

Oxid Med Cell Longev. 2017;2017:1512745. doi: 10.1155/2017/1512745. Epub 2017 Jan 16.

Oxidative Stress Triggered by Apigenin Induces Apoptosis in a Comprehensive Panel of Human Cervical Cancer-Derived Cell Lines.

Souza RPBonfim-Mendonça PSGimenes FRatti BAKaplum VBruschi MLNakamura CVSilva SOMaria-Engler SSConsolaro ME.

Orchid root extract was shown to have cytotoxic effects on human cervical adenocarcinoma cell line HeLa.

 

Phytomedicine. 2017 Jan 15;24:157-165. doi: 10.1016/j.phymed.2016.11.018. Epub 2016 Nov 23.

Eulophia macrobulbon - an orchid with significant anti-inflammatory and antioxidant effect and anticancerogenic potential exerted by its root extract.

Schuster RZeindl LHolzer WKhumpirapang NOkonogi SViernstein HMueller M.

This paper found that silver nanoparticles coated with Zataria Multiflora inhibited cancer cell metastasis.

Iran J Pharm Res2018 Spring;17(2):627-639.

Silver Nanoparticles Synthesized Coating with Zataria Multiflora Leaves Extract Induced Apoptosis in HeLa Cells Through p53 Activation.

Baharara JRamezani THosseini NMousavi M.