General and other
in the peer-reviewed medical literature
None of the 700+ studies listed on this site can substitute for consulting a licensed naturopathic physician. And none can be expected to function as stand-alone, at-home treatment.
Intravenous Vitamin C can be safely used in a concentration that is toxic to malignant cells.
P R Health Sci J. 2002 Mar;21(1):39-41.
Orthomolecular oncology: a mechanistic view of intravenous ascorbate's chemotherapeutic activity.
Vitamin C / Ascorbate is the single most essential nutrient for resistance to cancer.
Int J Vitam Nutr Res Suppl. 1982;23:115-27.
Vitamin C and cancer: an overview.
Humans are able to use Vitamin C / ascorbate in multiple ways to resist cancer.
Cancer Res. 1979 Mar;39(3):663-81.
Ascorbic acid and cancer: a review.
Survival time of cancer patients was 4.2 times as long for Vitamin C/ascorbic acid treated patients as controls. Safety of Vitamin C was confirmed.
Proc Natl Acad Sci U S A. 1976 Oct;73(10):3685-9.
Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer.
Vitamin C / ascorbic acid selectively kills cancer cells.
Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13604-9. Epub 2005 Sep 12.
Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues.
Vitamin C / ascorbic acid decreases aggressive tumor growth.
Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11105-9. doi: 10.1073/pnas.0804226105. Epub 2008 Aug 4.
Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice.
Aggressive cancers may be slowed or even stopped with combined therapy of sodium bicarbonate and Vitamin C.
Med Hypotheses. 2013 Oct;81(4):664-70. doi: 10.1016/j.mehy.2013.07.023. Epub 2013 Aug 2.
Expression and/or activity of the SVCT2 ascorbate transporter may be decreased in many aggressive cancers, suggesting potential utility for sodium bicarbonate and dehydroascorbic acid in cancer therapy.
Treatment with high dose vitamin C intravenously, helped to decrease pain and other radiation side effects in patients with bone metastasis after radiation therapy.
Altern Ther Health Med. 2014 Oct;20 Suppl 2:16-20.
Ascorbic-acid Treatment for Progressive Bone Metastases After Radiotherapy: A Pilot Study.
Nine case studies in Singapore on high doses of vitamin C in cancer patients showed improved survival time, quality of life, as well as improved tolerance of conventional therapies.
Integr Cancer Ther. 2016 Jun;15(2):197-204. doi: 10.1177/1534735415622010. Epub 2015 Dec
Effects of High Doses of Vitamin C on Cancer Patients in Singapore: Nine Cases.
There has been found to be an inhibitory effect on angiogenesis by a nutrient mixture with vitamin C, lysine, proline, and green tea extract.
Oncol Rep. 2005 Oct;14(4):807-15.
Inhibitory effect of a mixture containing ascorbic acid, lysine, proline and green tea extract on critical parameters in angiogenesis.
Surveys of 172 practitioners who used intravenous vitamin C with cancer patients, shows a high amount of satisfaction with its results and low side effects.
PLoS One. 2010 Jul 7;5(7):e11414. doi: 10.1371/journal.pone.0011414.
Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects.
Studies show that taking oral supplementation of vitamin C and green tea do not interfere with the antitumor effect of the chemo agent, bortezomib
Cancer Chemother Pharmacol. 2011 Nov;68(5):1145-54. doi: 10.1007/s00280-011-1591-2. Epub 2011 Mar 13.
Preclinical evaluation of the antitumor activity of bortezomib in combination with vitamin C or with epigallocatechin gallate, a component of green tea.
The formula LCS101 consisting of 14 botanical components has been proven to increase cell death when used in conjunction with radiation therapy.
J Cancer Res Clin Oncol. Cohen Z, Samuels N, Maimon Y, Berger R. Effect of the botanical formula LCS101 on the anti-cancer effects of radiation therapy. 2019 Mar;145(3):609-613. doi: 10.1007/s00432-018-2812-4. Epub 2018 Dec 6. PubMed PMID: 30523409.
Vitamin D deficiency may be involved in cancer progression, since countries with lower amounts of sunlight have higher cancer death rates, the cancers examined were: bladder cancer, breast cancer, colon-rectum cancer, lung cancer, oesophagus cancer, oral cancer, ovary cancer, pancreas cancer, skin cancer and stomach cancer.
Anticancer Agents Med Chem. Câmara AB, Brandãob IA. The Role of Vitamin D and Sunlight Incidence in Cancer. 2019 Mar 12;. doi: 10.2174/1389557519666190312123212. [Epub ahead of print] PubMed PMID: 30864510.
Astrakurkurone, which is found in a wild edible mushroom has been shown to cause cancer cell death.
IUBMB Life Dasgupta A, Dey D, Ghosh D, Lai TK, Bhuvanesh N, Dolui S, Velayutham R, Acharya K.Astrakurkurone, a Sesquiterpenoid from Wild Edible Mushroom, Targets Liver Cancer Cells by Modulating Bcl-2 Family Proteins. . 2019 Apr 12;. doi: 10.1002/iub.2047. [Epub ahead of print] PubMed PMID: 30977280.
Betulinic Acid, a naturally occurring compound, is highly toxic to cancer cells but it is a hard molecule to introduce to the body but this study found a delivery method which works well.
Front Chem. Nicolov M, Ghiulai RM, Voicu M, Mioc M, Duse AO, Roman R, Ambrus R, Zupko I, Moaca EA, Coricovac DE, Farcas C, Racoviceanu RM, Danciu C, Dehelean CA, Soica C. Cocrystal Formation of Betulinic Acid and Ascorbic Acid: Synthesis, Physico-Chemical Assessment, Antioxidant, and Antiproliferative Activity. . 2019;7:92. doi: 10.3389/fchem.2019.00092. eCollection 2019. PubMed PMID: 30847340; PubMed Central PMCID: PMC6393380.
The flowering plant Bauhinia variegata native to Southeast Asia induces the death of cancer cells and inhibits tumors from spreading.
Biomed Res Int. Santos KM, Gomes INF, Silva-Oliveira RJ, Pinto FE, Oliveira BG, Chagas RCR, Romão W, Reis RMV, Ribeiro RIMA. Bauhinia variegata candida Fraction Induces Tumor Cell Death by Activation of Caspase-3, RIP, and TNF-R1 and Inhibits Cell Migration and Invasion In Vitro. 2018;2018:4702481. doi: 10.1155/2018/4702481. eCollection 2018. PubMed PMID: 29770331; PubMed Central PMCID: PMC5889885.
Japanese knotweed (Polygonum Cuspidatum) a plant used in Chinese herbal medicine has active ingredients with antitumor effects.
Evid Based Complement Alternat Med. Wu X, Li Q, Feng Y, Ji Q. Antitumor Research of the Active Ingredients from Traditional Chinese Medical Plant Polygonum Cuspidatum. 2018;2018:2313021. doi: 10.1155/2018/2313021. eCollection 2018. Review. PubMed PMID: 30584449; PubMed Central PMCID: PMC6280292.
Essential oils frankincense and especially myrrh, have shown significant anti-cancer effects.
Oncol Lett. 2013 Oct; 6(4): 1140–1146.
Published online 2013 Aug 8. doi: 10.3892/ol.2013.1520
Composition and potential anticancer activities of essential oils obtained from myrrh and frankincense
Asparagus adscendens Roxb., is native to the Himalayas and demonstrated a potential source of cytotoxic compounds with anticancer potential
Pharmacogn Mag. 2018 Jan;13(Suppl 4):S890-S894. doi: 10.4103/pm.pm_136_17. Epub 2018 Jan 31.
Liquid Chromatography Mass Spectrometry Analysis and Cytotoxicity of Asparagus adscendens Roots against Human Cancer Cell Lines.
Oplopanax elatus, used as a natural medicine in China, showed an ability to suppress proliferation of human breast, stomach, and colon cancer cells
Curr Pharm Biotechnol. 2018 May 14. doi: 10.2174/1389201019666180515105447. [Epub ahead of print]
Anticancer activity of an Oplopanax elatus stem extract and biologically active isolated compounds.
This paper examines the anti-cancer benefits of modifying the structure of naturally occurring products, specifically from oleanolic and glycyrrhetinic acids. These are derived from olive oil and licorice respectively.
Drug Des Devel Ther. 2018 May 21;12:1321-1336. doi: 10.2147/DDDT.S166051. eCollection 2018.
PMID:29861624 Free PMC Article
Design and preparation of derivatives of oleanolic and glycyrrhetinic acids with cytotoxic properties.
A study on the efficacy of a support program for cancer patients that focuses on mind-body medicine and lifestyle modification.
Psychooncology. 2017 Dec;26(12):2127-2134. doi: 10.1002/pon.4433. Epub 2017 May 9.
Mind-body medicine and lifestyle modification in supportive cancer care: A cohort study on a day care clinic program for cancer patients.
This review summarizes classification of enzymes, their aberrant expression in cancerous tissue, structures, sources, and the anticancer mechanisms of enzyme inhibitors, both naturally occurring and synthetic, as well as the inhibitors that are either FDA-approved or under clinical trials.
Nutrients. 2018 Jun 6;10(6). pii: E731. doi: 10.3390/nu10060731.
Targeting Histone Deacetylases with Natural and Synthetic Agents: An Emerging Anticancer Strategy.
Betaine, widely distributed in animals, plants, and microorganisms, has beneficial actions in several human diseases, such as obesity, diabetes, cancer, and Alzheimer's disease.
Front Immunol. 2018 May 24;9:1070. doi: 10.3389/fimmu.2018.01070. eCollection 2018.
This review revisits and updates the current knowledge on the molecular mechanisms involved in the anticancer action of phytosterols and their potential in cancer prevention or treatment.
Curr Med Chem. 2018 Jun 6. doi: 10.2174/0929867325666180607093111. [Epub ahead of print]
Phytosterols in cancer: From molecular mechanisms to preventive and therapeutic potentials.
Based on the overall literature data, this paper describes a nutritional intervention consisting in a plant-based moderate ketogenic diet that could be exploited for future preclinical research in cancer therapy.
Front Oncol. 2018 May 8;8:148. doi: 10.3389/fonc.2018.00148. eCollection 2018.
Pushing the Limits of Cancer Therapy: The Nutrient Game.
This paper identifies and highlights all the mechanisms involved in the chemotherapeutic activity of caffeine.
Biomed Pharmacother. 2018 Jun 1;105:312-319. doi: 10.1016/j.biopha.2018.05.144. [Epub ahead of print]
This study suggest that treatment with Rhodiola crenuleta extract can induce cytotoxic effects in neuroblastoma cells.
Tumour Biol. 2018 Jun;40(6):1010428318779515. doi: 10.1177/1010428318779515.
Evaluation of Rhodiola crenulata on growth and metabolism of NB-1691, an MYCN-amplified neuroblastoma cell line.
L-carnitine supplementation may be a good approach for a multi-targeted therapy for the treatment of cancer-related cachexia.
Clin Nutr. 2012 Dec;31(6):889-95. doi: 10.1016/j.clnu.2012.03.005. Epub 2012 May 19.
L-Carnitine: an adequate supplement for a multi-targeted anti-wasting therapy in cancer.
Curcumin/Ascorbic Acid identifies several candidate genes that may regulate the response of varied cancer cells.
Front Pharmacol. 2017 Feb 2;8:38. doi: 10.3389/fphar.2017.00038. eCollection 2017.
Pharmacogenomic Characterization and Isobologram Analysis of the Combination of Ascorbic Acid and Curcumin-Two Main Metabolites of Curcuma longa-in Cancer Cells.
Pseudocedrela kotschyi exhibited marked anticancer activity.
Pharmacognosy Res. 2017 Jan-Mar;9(1):46-50. doi: 10.4103/0974-8490.199776.
Cytotoxicity Studies of the Extracts, Fractions, and Isolated Compound of Pseudocedrela kotschyi on Cervical Cancer (HeLa), Breast Cancer (MCF-7) and Skeletal Muscle Cancer (RD) Cells.
Riboflavin and thiamine show promising potential in the treatment of cancer.
Pharm Res. 2016 Jul;33(7):1769-81. doi: 10.1007/s11095-016-1916-2. Epub 2016 Apr 18.
Development and Characterization of the Paclitaxel loaded Riboflavin and Thiamine Conjugated Carbon Nanotubes for Cancer Treatment.
Oregano vulgare main component is 4-terpineol and was effective in inhibiting cancer cell growth.
J Med Food. 2014 Oct;17(10):1129-33. doi: 10.1089/jmf.2013.0063. Epub 2014 Sep 17.
Composition and antiproliferative effect of essential oil of Origanum vulgare against tumor cell lines.
Huanglian is a promising herb for chemoprevention and chemotherapy of certain cancers.
Carcinogenesis. 2005 Nov;26(11):1934-9. Epub 2005 Jun 15.
The extract of huanglian, a medicinal herb, induces cell growth arrest and apoptosis by upregulation of interferon-beta and TNF-alpha in human breast cancer cells.
Goldenseal is a potential anti-cancer herb.
Environ Toxicol Pharmacol. 2013 Jul;36(1):202-14. doi: 10.1016/j.etap.2013.03.023. Epub 2013 Apr 8.
Ethanolic extract of Goldenseal, Hydrastis canadensis, has demonstrable chemopreventive effects on HeLa cells in vitro: Drug-DNA interaction with calf thymus DNA as target.
Rumex genus compounds have potential role in cancer therapy due to its compounds.
BMC Complement Altern Med. 2016 Aug 24;16:308. doi: 10.1186/s12906-016-1302-y.
Evaluation of Rumex hastatus D. Don for cytotoxic potential against HeLa and NIH/3T3 cell lines: chemical characterization of chloroform fraction and identification of bioactive compounds.
Rumex Hastatus possesses both anti-tumor and anti-angiogenic potentials.
Biol Res. 2016 Mar 12;49:18. doi: 10.1186/s40659-016-0079-2.
Antitumor and anti-angiogenic potentials of isolated crude saponins and various fractions of Rumex hastatus D. Don.
Cat's claw might be beneficial in patients with advanced cancer by improving their quality of life and reducing fatigue.
J Altern Complement Med. 2015 Jan;21(1):22-30. doi: 10.1089/acm.2014.0127. Epub 2014 Dec 11.
Uncaria tomentosa (cat's claw) improves quality of life in patients with advanced solid tumors.
A nutrient mixture with vitamin C, lysine, proline, and green tea extract has been shown to inhibit human neuroblastoma cells in lab studies.
Oncol Rep. 2013 May;29(5):1714-20. doi: 10.3892/or.2013.2307. Epub 2013 Feb 27.
Inhibition of the SK-N-MC human neuroblastoma cell line in vivo and in vitro by a novel nutrient mixture.
Eupatilin may serve as a potential therapeutic agent for the treatment of human renal cancer.
Oncol Lett. 2016 Oct;12(4):2894-2899. Epub 2016 Aug 10.
Eupatilin induces human renal cancer cell apoptosis via ROS-mediated MAPK and PI3K/AKT signaling pathways.
DMSO and sodium bicarbonate, iv, helps to relieve unmanageable cancer pain in cancer patients.
J Pain Palliat Care Pharmacother. 2011;25(1):19-24. doi: 10.3109/15360288.2010.536306.
Dimethyl sulfoxide and sodium bicarbonate in the treatment of refractory cancer pain.
Intravenous vitamin C helps to relieve chemo-related fatigue and improve quality of life in cancer patients.
Front Oncol. 2014 Oct 16;4:283. doi: 10.3389/fonc.2014.00283. eCollection 2014.
The effect of intravenous vitamin C on cancer- and chemotherapy-related fatigue and quality of life.
Essential oils are proven to provide protection of the liver from the toxic chemotherapy drug, cyclophosphamide, in mice.
PLoS One. 2016 Nov 1;11(11):e0165667. doi: 10.1371/journal.pone.0165667. eCollection 2016.
Protective Effects of Essential Oils as Natural Antioxidants against Hepatotoxicity Induced by Cyclophosphamide in Mice.
Crude extract of Rheum palmatum may have anticancer effects for osteosarcoma.
Environ Toxicol. 2016 Aug;31(8):957-69. doi: 10.1002/tox.22105. Epub 2015 Feb 17.
Crude extract of Rheum palmatum L. Induces cell cycle arrest S phase and apoptosis through mitochondrial-dependent pathways in U-2 OS human osteosarcoma cells.
Cornelian cherry may have potential as a novel anticancer agent for the treatment of osteosarcoma.
Environ Toxicol. 2015 Jan;30(1):53-63. doi: 10.1002/tox.21894. Epub 2013 Aug 19.
The crude extract of Corni Fructus inhibits the migration and invasion of U-2 OS human osteosarcoma cells through the inhibition of matrix metalloproteinase-2/-9 by MAPK signaling.
Red sage extract has inhibitory effect on Oral Squamous Cell Carcinoma cell growth.
BMC Complement Altern Med. 2011 Jul 5;11:54. doi: 10.1186/1472-6882-11-54.
Modulation of growth and angiogenic potential of oral squamous carcinoma cells in vitro using salvianolic acid B.
Extracts of Artemisia annua (AMR), Rumex abyssinicus (RMA), and Catha edulis Forsk (CEF) have anti-tumor effects.
ISRN Biochem. 2013 Sep 22;2013:910308. doi: 10.1155/2013/910308. eCollection 2013.
Evaluation of the In Vitro Efficacy of Artemisia annua, Rumex abyssinicus, and Catha edulis Forsk Extracts in Cancer and Trypanosoma brucei Cells.
Huang-Qin could be used to block tumor necrosis.
Cancer Sci. 2011 Apr;102(4):870-6. doi: 10.1111/j.1349-7006.2011.01874.x. Epub 2011 Feb 24.
Catalase suppression-mediated H(2)O(2) accumulation in cancer cells by wogonin effectively blocks tumor necrosis factor-induced NF-κB activation and sensitizes apoptosis.
Dandelion could be a non-toxic and effective anti-cancer alternative.
Oncotarget. 2016 Nov 8;7(45):73080-73100. doi: 10.18632/oncotarget.11485.
Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways.
The long history of human use, remarkable nontoxicity, and preclinical efficacy strongly favor the clinical use of silibinin against advanced metastatic cancers.
Cancer Metastasis Rev. 2010. Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer. Review article. Deep G, et al. https://www.ncbi.nlm.nih.gov/m/pubmed/20714788/
Quercetin inhibits protein kinases involved in deregulated cell growth in cancer cells.
Emerging evidence provides credible support in favor of the potential role of bioactive products derived from ingesting cruciferous vegetables such as broccoli, brussel sprouts, cauliflower and cabbage. This study focuses on 3,3'-diindolylmethane (DIM) and its anti-cancer effects.
Mutat Res. Attenuation of multi-targeted proliferation-linked signaling by 3,3'-diindolylmethane (DIM): from bench to clinic. Review article. Banerjee S, et al. 2011 Jul-Oct. https://www.ncbi.nlm.nih.gov/m/pubmed/21703360/
Curcumin mediates its anti-proliferative, anti-invasive and apoptotic effects on cancer cells, including cancer stem/progenitor cells and their progenies, through multiple molecular mechanisms.
Chin Med. Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy. Mimeault M, et al. 2011. https://www.ncbi.nlm.nih.gov/m/pubmed/21859497/
Multicomponent therapy forms the basis of phytotherapy or phytomedicine where the holistic therapeutic effect arises as a result of complex positive (synergistic) or negative (antagonistic) interactions between different components.
Phytomedicine. Multicomponent phytotherapeutic approach gaining momentum: Is the "one drug to fit all" model breaking down? Review article. Rather MA, et al. 2013. https://www.ncbi.nlm.nih.gov/m/pubmed/24035674/
Vitamin C / ascorbate has effectively eliminated cancers in humans without toxic reactions.
P R Health Sci J. 2004 Jun;23(2):115-8.
Intravenous vitamin C as a chemotherapy agent: a report on clinical cases.
Vitamin C / ascorbate is more effective against cancer when used intravenously than orally.
P R Health Sci J. 2008 Mar;27(1):7-19.
Pharmacokinetics of vitamin C: insights into the oral and intravenous administration of ascorbate.