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Colorectal Cancer Research

in the peer-reviewed medical literature

None of the 700+ studies listed on this site can substitute for consulting a licensed naturopathic physician.  And none can be expected to function as stand-alone, at-home treatment.

A compound produced by the liver by processing vitamin D3 is associated with lower risk of Colorectal Cancer.


Clin Lab.  Guo J, Sun C, Wang B, Ma K, Li F, Wang Y, Hou W. Associations between Vitamin D and β-Cell Function and Colorectal Cancer-Associated Tumor Markers in Chinese Type 2 Diabetic Patients with Albuminuria. 2019 Apr 1;65(4). doi: 10.7754/Clin.Lab.2019.181111. PubMed PMID: 30969095.


Inula Viscosa Extract Inhibits Growth of Colorectal Cancer Cells in vitro and in vivo


Front Oncol.  Bar-Shalom R, Bergman M, Grossman S, Azzam N, Sharvit L, Fares F. Inula ViscosaExtract Inhibits Growth of Colorectal Cancer Cells in vitro and in vivo Through Induction of Apoptosis. 2019;9:227. doi: 10.3389/fonc.2019.00227. eCollection 2019. PubMed PMID: 31024836; PubMed Central PMCID: PMC6469364.


Vitamin D3 plus omega-3 fatty acids co-supplementation in colorectal cancer patients has beneficial impacts on inflammation and nutritional status.


J Diet Suppl.   Haidari F, Abiri B, Iravani M, Ahmadi-Angali K, Vafa M. Randomized Study of the Effect of Vitamin D and Omega-3 Fatty Acids Cosupplementation as Adjuvant Chemotherapy on Inflammation and Nutritional Status in Colorectal Cancer Patients. 2019 May 20;:1-17. doi: 10.1080/19390211.2019.1600096. [Epub ahead of print] PubMed PMID: 31106659.


A method of delivering Vitamin D known as nano-emulsion was shown to be effective in inhibiting the growth and promoting the death of colorectal cancer cells.


Cell Biosci.  Razak S, Afsar T, Almajwal A, Alam I, Jahan S. Growth inhibition and apoptosis in colorectal cancer cells induced by Vitamin D-Nanoemulsion (NVD): involvement of Wnt/β-catenin and other signal transduction pathways. 2019;9:15. doi: 10.1186/s13578-019-0277-z. eCollection 2019. PubMed PMID: 30733856; PubMed Central PMCID: PMC6359839.


An herbal formula consisting of Descurainia sophia and Peucedani praeruptorum is shown to significantly slow tumor growth and increase the death of cancer cells when combined with other cancer treatment drugs.


Biomed Pharmacother.  Kim J, Kim HY, Hong S, Shin S, Kim YA, Kim NS, Bang OS. A new herbal formula BP10A exerted an antitumor effect and enhanced anticancer effect of irinotecan and oxaliplatin in the colon cancer PDTX model. 2019 May 18;116:108987. doi: 10.1016/j.biopha.2019.108987. [Epub ahead of print] PubMed PMID: 31112870.


A compound from the popular Chinese herb Sanguisorba officinalis is shown to cause the death of colorectal cancer cells.


Chin Med.   Li W, Yang CJ, Wang LQ, Wu J, Dai C, Yuan YM, Li GQ, Yao MC. A tannin compound fromSanguisorba officinalis blocks Wnt/β-catenin signaling pathway and induces apoptosis of colorectal cancer cells. 2019;14:22. doi: 10.1186/s13020-019-0244-y. eCollection 2019. PubMed PMID: 31164916; PubMed Central PMCID: PMC6544925.


Isobavachalcone a compound from the Chinese plant Psoralea corylifolia is shown to induce the death of colorectal cancer cells.


Drug Des Devel Ther.  Li Y, Qin X, Li P, Zhang H, Lin T, Miao Z, Ma S. Isobavachalcone isolated from Psoralea corylifolia inhibits cell proliferation and induces apoptosis via inhibiting the AKT/GSK-3β/β-catenin pathway in colorectal cancer cells. 2019;13:1449-1460. doi: 10.2147/DDDT.S192681. eCollection 2019. PubMed PMID: 31118579; PubMed Central PMCID: PMC6503305.


A compound from Lingzhi mushroom (Ganoderma lucidum) is shown to have inhibit the growth of colorectal cancer.


Cell Death DisPan H, Wang Y, Na K, Wang Y, Wang L, Li Z, Guo C, Guo D, Wang X. Autophagic flux disruption contributes to Ganoderma lucidum polysaccharide-induced apoptosis in human colorectal cancer cells via MAPK/ERK activation. 2019 Jun 11;10(6):456. doi: 10.1038/s41419-019-1653-7. PubMed PMID: 31186406; PubMed Central PMCID: PMC6560101.


Higher intake of vitamin B12, especially intake from milk, dairy and fish are associated with the low-risk diet and lifestyle in a population at high risk for Colorectal Cancer.


Cent Eur J Public Health.  Banjari I, Kožić S. Dietary intake of vitamin B12 in relation to diet and lifestyle characteristics in a population at high risk for colorectal cancer. 2018 Dec;26(4):253-259. doi: 10.21101/cejph.a4585. PubMed PMID: 30660133.

The anti-cancer effect of the food borne phytochemical phenolic acid is examined both in vitro and in vivo models of colon cancer.


Chem Biol Interact2018 Jun 4. pii: S0009-2797(18)30171-6. doi: 10.1016/j.cbi.2018.06.001. [Epub ahead of print]

Antiproliferative effect of p-Coumaric acid targets UPR activation by downregulating Grp78 in colon cancer.

Sharma SHRajamanickam VNagarajan S.



In lab experiments, compositions of phosphatidylcholine and DHA helped slow and even stop the liver metastasis of colon cancer.


Biol Pharm Bull. 2011;34(6):901-5.

Therapeutic effects of hybrid liposomes composed of phosphatidylcholine and docosahexaenoic acid on the hepatic metastasis of colon carcinoma along with apoptosis in vivo.

Ichihara H1, Zako K, Komizu Y, Goto K, Ueoka R.



Rhododendron luteum extract shows ability to selectively kill colon cancer and liver cancer cells.


J BUON. 2016 Jul-Aug;21(4):883-888.

Selective cytotoxic effect of Rhododendron luteum extract on human colon and liver cancer cells.

Demir S1, Turan I, Aliyazicioglu Y.



This study shows enteral glutamine exhibits some anti-inflammatory activity and, consequently, leads to a lower hormonal stress response during radiochemotherapy in patients with rectal cancer.

Eur J Clin Nutr. 2017 Mar 8. doi: 10.1038/ejcn.2017.11. [Epub ahead of print]

Influence of enteral glutamine on inflammatory and hormonal response in patients with rectal cancer during preoperative radiochemotherapy.

Rotovnik Kozjek N1, Kompan L1, Žagar T1, Mrevlje Ž2.


Astragalus influences immune-regulating properties involved in antitumor activity in liver cancer.


Dose Response. 2017 Jan 3;15(1):1559325816685182. doi: 10.1177/1559325816685182.

Therapeutic Effect of Astragalus Polysaccharides on Hepatocellular Carcinoma H22-Bearing Mice.

Lai X1, Xia W2, Wei J2, Ding X3.



Milk Thistle is shown to possess anti-cancer properties in a variety of epithelial cancers.


Int J Oncol. 2012 Sep;41(3):849-54. doi: 10.3892/ijo.2012.1526. Epub 2012 Jun 25.

Silibinin, a natural flavonoid, modulates the early expression of chemoprevention biomarkers in a preclinical model of colon carcinogenesis.

Kauntz H1, Bousserouel SGosse FMarescaux JRaul F.


The demonstrated effectiveness of Astragalus suggests a potential therapeutic drug for colorectal cancer.

Oncol Rep. 2016 Feb;35(2):659-68. doi: 10.3892/or.2015.4441. Epub 2015 Nov 23.

An in vivo molecular response analysis of colorectal cancer treated with Astragalus membranaceus extract.

Tseng A1, Yang CH2, Chen CH1, Chen CH3, Hsu SL4, Lee MH5, Lee HC6, Su LJ1.



​Supplemented zinc may have a positive effect in colorectal cancer treatment.


Biol Trace Elem Res. 2016 Jan;169(1):8-16. doi: 10.1007/s12011-015-0396-2. Epub 2015 Jun 12.

Effect of Zinc Supplementation on Antioxidant Defenses and Oxidative Stress Markers in Patients Undergoing Chemotherapy for Colorectal Cancer: a Placebo-Controlled, Prospective Randomized Trial.

Ribeiro SM1, Braga CB1, Peria FM2, Domenici FA1, Martinez EZ3, Feres O4, da Rocha JJ4, da Cunha SF5.



Acetyl carnitine is potentially beneficial as one of the anticarcinogenic nutrients that inhibit colon cancer cell survival in vitro.


Int J Oncol. 2015 Aug;47(2):755-63. doi: 10.3892/ijo.2015.3029. Epub 2015 Jun 4.

Acetylcarnitine potentiates the anticarcinogenic effects of butyrate on SW480 colon cancer cells.

Elimrani I1, Dionne S1, Saragosti D1, Qureshi I2, Levy E2, Delvin E2, Seidman EG1.



Curcumin and Silymarin are shown to be effective against colorectal cancer.


J Cancer. 2016 Jun 23;7(10):1250-7. doi: 10.7150/jca.15690. eCollection 2016.

Curcumin Sensitizes Silymarin to Exert Synergistic Anticancer Activity in Colon Cancer Cells.

Montgomery A1, Adeyeni T2, San K3, Heuertz RM3, Ezekiel UR3.



Americanin A Isolated from the Seeds of Phytolacca americana might be plausible mechanisms of action for the antiproliferative and antitumor activities of Phytolacca in human colon cancer cells.


J Nat Prod. 2015 Dec 24;78(12):2983-93. doi: 10.1021/acs.jnatprod.5b00743. Epub 2015 Nov 23.

Antitumor Activity of Americanin A Isolated from the Seeds of Phytolacca americana by Regulating the ATM/ATR Signaling Pathway and the Skp2-p27 Axis in Human Colon Cancer Cells.

Jung C1, Hong JY1, Bae SY1, Kang SS1, Park HJ1, Lee SK1.



Grape seed extract may be an effective chemopreventive agent against colorectal cancer.


Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6194-202.

Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells.

Kaur M1, Singh RPGu MAgarwal RAgarwal C.



Boswellia Serrata extract has great potential to suppress colon tumorigenesis.


Mol Nutr Food Res. 2017 Feb 28. doi: 10.1002/mnfr.201600984. [Epub ahead of print]

Boswellia serrata resin extract alleviates azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colon tumorigenesis.

Chou YC1, Suh JH2, Wang Y2, Pahwa M3, Badmeav V4, Ho CT5, Pan MH1,6,7.


Quercetin could be a potent therapeutic agent for the treatment of metastatic colorectal cancer.


Phytomedicine. 2016 Dec 1;23(13):1680-1690. doi: 10.1016/j.phymed.2016.09.011. Epub 2016 Oct 1.

Inhibitory effect of quercetin on colorectal lung metastasis through inducing apoptosis, and suppression of metastatic ability.

Kee JY1, Han YH1, Kim DS1, Mun JG1, Park J2, Jeong MY3, Um JY4, Hong SH5.



Phytolacca Americana may be useful in the treatment of colon cancer.

Phytother Res. 2014 Feb;28(2):219-23. doi: 10.1002/ptr.4979. Epub 2013 Apr 4.

Impact of Phytolacca americana extracts on gene expression of colon cancer cells.

Maness L1, Goktepe I, Chen H, Ahmedna M, Sang S.

Rice Bran promotes significant inhibitory activities in colon and liver cancer cells.


J Agric Food Chem. 2008 Dec 24;56(24):11643-7. doi: 10.1021/jf802558v.

Human colon and liver cancer cell proliferation inhibition by peptide hydrolysates derived from heat-stabilized defatted rice bran.

Kannan A1, Hettiarachchy NJohnson MGNannapaneni R.


A multi-mineral approach may be a chemo-prevention of colon cancer.

Mol Carcinog. 2015 Jul;54(7):543-53. doi: 10.1002/mc.22123. Epub 2013 Dec 17.

Induction of calcium sensing receptor in human colon cancer cells by calcium, vitamin D and aquamin: Promotion of a more differentiated, less malignant and indolent phenotype.

Singh N1, Aslam MN2, Varani J2, Chakrabarty S1


Sijunzi could improve the immune function and quality of life of colorectal cancer patients.


Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011 Feb;31(2):164-7.

[Immune enhancing effect of modified sijunzi decoction on patients with colorectal cancer undergoing chemotherapy].

[Article in Chinese]

Xiao H1, Yang J.


Tienchi ginseng is promising as a useful botanical product in colorectal cancer chemoprevention.



Food Chem. 2011 Apr 15;125(4):1299-1305.

Red notoginseng: higher ginsenoside content and stronger anticancer potential than Asian and American ginseng.

Sun S1, Qi LWDu GJMehendale SRWang CZYuan CS.

Panaxadiol and irinotecan found in ginseng has antiproliferative effects of irinotecan on human colorectal cancer cells


J Pharm Pharmacol. 2012 May;64(5):727-34. doi: 10.1111/j.2042-7158.2012.01463.x. Epub 2012 Feb

Caspase-mediated pro-apoptotic interaction of panaxadiol and irinotecan in human colorectal cancer cells.

Du GJ1, Wang CZZhang ZYWen XDSomogyi JCalway THe TCDu WYuan CS.



Notoginseng extracts were observed having a most potent effect, supporting an antiproliferative effect against human colorectal cancer cells.


Phytother Res. 2009 Jan;23(1):6-13. doi: 10.1002/ptr.2383.

Antiproliferative effects of different plant parts of Panax notoginseng on SW480 human colorectal cancer cells.

Wang CZ1, Xie JTFishbein AAung HHHe HMehendale SRHe TCDu WYuan CS.



Grapeseed extract may be useful for colorectal cancer prevention and treatment.


Curr Cancer Drug Targets. 2014;14(4):323-36.

Target identification of grape seed extract in colorectal cancer using drug affinity responsive target stability (DARTS) technique: role of endoplasmic reticulum stress response proteins.

Derry MMSomasagara RRRaina KKumar SGomez JPatel MAgarwal RAgarwal C1.


Blood root extract may have a potential therapeutic use in the treatment of human colon cancer.


Int J Toxicol. 2012 Jan-Feb;31(1):70-7. doi: 10.1177/1091581811423845. Epub 2012 Jan 3.

Sanguinarine induces apoptosis of HT-29 human colon cancer cells via the regulation of Bax/Bcl-2 ratio and caspase-9-dependent pathway.

Lee JS1, Jung WKJeong MHYoon TRKim HK.


Watercress extract proved to be significantly protective against the three stages of the colon cancer carcinogenesis process.


Nutr Cancer. 2006;55(2):232-41.

Assessment of the anti-genotoxic, anti-proliferative, and anti-metastatic potential of crude watercress extract in human colon cancer cells.

Boyd LA1, McCann MJHashim YBennett RNGill CIRowland IR.


Phenols extracted from virgin olive oil are capable of inhibiting several stages in colon carcinogenesis.

Int J Cancer. 2005 Oct 20;117(1):1-7.

Potential anti-cancer effects of virgin olive oil phenols on colorectal carcinogenesis models in vitro.

Gill CI1, Boyd AMcDermott EMcCann MServili MSelvaggini RTaticchi AEsposto SMontedoro GMcGlynn HRowland I.


Aloe vera gel suppresses colitis-related colon carcinogenesis.


Int Immunopharmacol. 2016 Nov;40:428-435. doi: 10.1016/j.intimp.2016.09.022. Epub 2016 Sep 30.

Prevention of azoxymethane/dextran sodium sulfate-induced mouse colon carcinogenesis by processed Aloe vera gel.

Im SA1, Kim JW1, Kim HS1, Park CS1, Shin E2, Do SG2, Park YI3, Lee CK4.


Nutmeg may be effective in colon cancer chemoprevention strategies.

J Proteome Res. 2015 Apr 3;14(4):1937-46. doi: 10.1021/pr5013152. Epub 2015 Mar 10.

Modulation of colon cancer by nutmeg.

Li F1,2, Yang XW3, Krausz KW1, Nichols RG4, Xu W3, Patterson AD4, Gonzalez FJ1.

Curcumin, either the parental compound or its derivatives, may eventually find a place in the therapeutic management protocols of several conditions, including colon cancer. 


Scientifica   A neutraceutical by design: the clinical application of curcumin in colonic inflammation and cancer. Review article. Soni D, et al. (Cairo). 2012.

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