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Bladder Cancer Research

in the peer-reviewed medical literature

None of the 700+ studies listed on this site can substitute for consulting a licensed naturopathic physician.  And none can be expected to function as stand-alone, at-home treatment.

Higher levels of Vitamins A, E, and D were associated with lower occurrences of Urothelial Bladder Cancer.


Nutr Cancer.  Ben Fradj MK, Mrad Dali K, Kallel A, Bibi M, Ben Rhouma S, Sanhaji H, Nouira Y, Feki M.Interaction Effects of Plasma Vitamins A, E, D, B9, and B12 and Tobacco Exposure in Urothelial Bladder Cancer: A Multifactor Dimensionality Reduction Analysis. 2019 May 6;:1-8. doi: 10.1080/01635581.2019.1609531. [Epub ahead of print] PubMed PMID: 31058547.


Increased Vitamin E consumption is associated with lower occurrences of bladder cancer.


Int J Vitam Nutr  Lin JH, Chen SJ, Liu H, Yan Y, Zheng JH. Vitamin E consumption and the risk of bladder cancer. Res. 2019 Feb 26;:1-8. doi: 10.1024/0300-9831/a000553. [Epub ahead of print] PubMed PMID: 30806606.


Vitamin C in the body creates a compound which inhibits the growth of bladder cancer.

Clin Epigenetics  Peng D, Ge G, Gong Y, Zhan Y, He S, Guan B, Li Y, Xu Z, Hao H, He Z, Xiong G, Zhang C, Shi Y, Zhou Y, Ci W, Li X, Zhou L. Vitamin C increases 5-hydroxymethylcytosine level and inhibits the growth of bladder cancer. . 2018 Jul 13;10(1):94. doi: 10.1186/s13148-018-0527-7. PubMed PMID: 30005692; PubMed Central PMCID: PMC6045833.

Saponins dervied from Paris polyphylla var. yunnanensis, a Chinese herb, demonstrate the ability to inhibit bladder cancer cell growth


Curr Urol. 2018 Mar;11(3):131-138. doi: 10.1159/000447207. Epub 2018 Feb 20.

Paris Polyphylla-Derived Saponins Inhibit Growth of Bladder Cancer Cells by Inducing Mutant P53 Degradation While Up-Regulating CDKN1A Expression.

Guo YLiu ZLi KCao GSun CCheng GZhang DPeng WLiu JQi YZhang LWang PChen YLin ZGuan YZhang JWen JWang FKong FXu DZhao S.


Triterpene glycoside Actein, extracted from the herb Cimicifuga, induced autophagy and apoptosis in human bladder cancer. 


Oncotarget. 2017 Nov 1;8(68):112498-112515. doi: 10.18632/oncotarget.22274. eCollection 2017 Dec 22.

Actein induces autophagy and apoptosis in human bladder cancer by potentiating ROS/JNK and inhibiting AKT pathways.

Ji LZhong BJiang XMao FLiu GSong BWang CYJiao YWang JPXu ZBLi XZhan B.


Ganoderma lucidum possesses significant antioxidant and anti-cancer properties for bladder cancer.


J Ethnopharmacol. 2008 Jul 23;118(2):324-30. doi: 10.1016/j.jep.2008.05.003. Epub 2008 May 8.

The dual roles of Ganoderma antioxidants on urothelial cell DNA under carcinogenic attack.

Yuen JW1, Gohel MD.


Effects of frankincense and sandalwood essential oils on J82 cells and UROtsa cells involved different mechanisms leading to bladder cancer cell death. 


Chin Med. 2014 Jul 2;9:18. doi: 10.1186/1749-8546-9-18. eCollection 2014.

Differential effects of selective frankincense (Ru Xiang) essential oil versus non-selective sandalwood (Tan Xiang) essential oil on cultured bladder cancer cells: a microarray and bioinformatics study.

Dozmorov MG1, Yang Q2, Wu W3, Wren J1, Suhail MM4, Woolley CL5, Young DG5, Fung KM6, Lin HK7.


Sulforaphane inhibits the proliferation of bladder cancer cells.


Asian Pac J Cancer Prev. 2014;15(4):1517-20.

Sulforaphane inhibits the proliferation of the BIU87 bladder cancer cell line via IGFBP-3 elevation.

Dang YM1, Huang GChen YRDang ZFChen CLiu FLGuo YFXie XD.


Rehmannia glutinosa extract might serve to be a promising therapeutic agent for the treatment of human bladder cancer.

Cell Biochem Biophys. 2015 Apr;71(3):1349-56. doi: 10.1007/s12013-014-0355-0.

Catalpol Inhibited the Proliferation of T24 Human Bladder Cancer Cells by Inducing Apoptosis Through the Blockade of Akt-Mediated Anti-apoptotic Signaling.

Jin D1, Cao M1, Mu X1, Yang G1, Xue W1, Huang Y1, Chen H2.

Vitamin E was found to be especially useful against bladder cancer.

Int J Clin Exp Med. 2014 Nov 15;7(11):4154-64. eCollection 2014.

Vitamin C and E intake and risk of bladder cancer: a meta-analysis of observational studies.

Wang YY1, Wang XL1, Yu ZJ1.

Plasma carotenoids were inversely correlated with urothelial cell carcinoma.

Urol Oncol. 2013 Jul;31(5):714-5. doi: 10.1016/j.urolonc.2013.03.015.

Commentary on "Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition." Ros MM, Bueno de Mesquita HB, Kampman E, Aben KK, Büchner FL, Jansen EH, van Gils CH, Egevad L, Overvad K, Tjønneland A, Roswall N, Boutron Ruault MC, Kvaskoff M, Perquier F, Kaaks R, Chang Claude J, Weikert S, Boeing H, Trichopoulou A, Lagiou P, Dilis V, Palli D, Pala V, Sacerdote C, Tumino R, Panico S, Peeters PH, Gram IT, Skeie G, Huerta JM, Barricarte A, Quirós JR, Sánchez MJ, Buckland G, Larrañaga N, Ehrnström R, Wallström P, Ljungberg B, Hallmans G, Key TJ, Allen NE, Khaw KT, Wareham N, Brennan P, Riboli E, Kiemeney LA, National Institute for Public Health and the Environment, Bilthoven, Netherlands: Am J Clin Nutr 2012;96(4):902-10 [Epub 2012 Sep 5].

Combined Vitamin C / ascorbate and Vitamin  K3 / menadione killed cancer cells.

Ultrastruct Pathol. 2010 May;34(3):140-60. doi: 10.3109/01913121003662304.

Cell damage and death by autoschizis in human bladder (RT4) carcinoma cells resulting from treatment with ascorbate and menadione.

Gilloteaux J1, Jamison JMNeal DRLoukas MDoberzstyn TSummers JL.


Garlic extract shows inhibitory effects on proliferation, migration, and invasion of EJ cells in bladder cancer.


PLoS One. 2017 Feb 10;12(2):e0171860. doi: 10.1371/journal.pone.0171860. eCollection 2017.

HSPA6 augments garlic extract-induced inhibition of proliferation, migration, and invasion of bladder cancer EJ cells; Implication for cell cycle dysregulation, signaling pathway alteration, and transcription factor-associated MMP-9 regulation.

Shin SS1, Song JH2, Hwang B2, Noh DH2, Park SL2, Kim WT3, Park SS1, Kim WJ3, Moon SK2.



Extra virgin olive oil significantly inhibited proliferation and clonogenic ability in bladder cancer cells.

Oncol Rep. 2016 Dec;36(6):3095-3104. doi: 10.3892/or.2016.5150. Epub 2016 Oct 5.

Extra-virgin olive oil phenols block cell cycle progression and modulate chemotherapeutic toxicity in bladder cancer cells.

Coccia A1, Mosca L2, Puca R1, Mangino G1, Rossi A3, Lendaro E1.       



Grape seed extract inhibits cell proliferation by inducing cell cycle arrest and apoptosis.


Eur Rev Med Pharmacol Sci. 2016 Jul;20(15):3282-91.

Induction of cell cycle arrest and apoptosis by grape seed procyanidin extract in human bladder cancer BIU87 cells.

Liu J1, Zhang WYKong ZHDing DG.



Trillium govanianum methanol extract and all SPE fractions exhibited considerable levels of cytotoxicity against bladder cancer cells.


Phytother Res. 2016 Oct;30(10):1716-1720. doi: 10.1002/ptr.5672. Epub 2016 Jul 1.

Cytotoxicity of the Roots of Trillium govanianum Against Breast (MCF7), Liver (HepG2), Lung (A549) and Urinary Bladder (EJ138) Carcinoma Cells.

Khan KM1,2, Nahar L1, Al-Groshi A1, Zavoianu AG1, Evans A1, Dempster NM1, Wansi JD1, Ismail FM1, Mannan A2, Sarker SD3.



Pumpkin seed extract shows inhibition in bladder cancer cells.


Fitoterapia. 2016 Apr;110:150-6. doi: 10.1016/j.fitote.2016.03.010. Epub 2016 Mar 11.

Pumpkin seed extract: Cell growth inhibition of hyperplastic and cancer cells, independent of steroid hormone receptors.

Medjakovic S1, Hobiger S2, Ardjomand-Woelkart K3, Bucar F4, Jungbauer A5.



Mulberry water extract is an effective therapeutic option for bladder cancer treatment strategies.

Sci Rep. 2016 Feb 3;6:20417. doi: 10.1038/srep20417.

Promotion of mitotic catastrophe via activation of PTEN by paclitaxel with supplement of mulberry water extract in bladder cancer cells.

Chen NC1, Chyau CC2, Lee YJ3, Tseng HC4,5, Chou FP1,6.



Protosappanin B extracted from Lignum Sappan exerts marked antitumor effects in bladder cancer.


Integr Cancer Ther. 2016 Mar;15(1):87-95. doi: 10.1177/1534735415588929. Epub 2015 Jun 2.

Antitumor Effects of Purified Protosappanin B Extracted From Lignum Sappan.

Yang X1, Ren L2, Zhang S3, Zhao L1, Wang J1.



Crude brazilin extract from Sappan wood may inhibit Human bladder carcinoma cell growth and trigger cell death.


IUBMB Life. 2015 Mar;67(3):175-81. doi: 10.1002/iub.1357. Epub 2015 Apr 11.

c-Fos is involved in inhibition of human bladder carcinoma T24 cells by brazilin.

Zhang T1, Fan XSong LRen LMa EZhang SRen LZheng YZhang J.



Brazilian red propolis may be a potential source for bladder cancer treatment.


Evid Based Complement Alternat Med. 2014;2014:639856. doi: 10.1155/2014/639856. Epub 2014 Nov 3.

Brazilian red propolis induces apoptosis-like cell death and decreases migration potential in bladder cancer cells.

Begnini KR1, Moura de Leon PM1, Thurow H1, Schultze E1, Campos VF1, Martins Rodrigues F2, Borsuk S3, Dellagostin OA3, Savegnago L3, Roesch-Ely M4, Moura S4, Padilha FF5, Collares T1, Pêgas Henriques JA4, Seixas FK1.



Pomegranate fruit ethanol extract (PEE) could effectively restrict the proliferation of bladder cancer cells.

BMC Complement Altern Med. 2013 Dec 21;13:364. doi: 10.1186/1472-6882-13-364.

Suppression of urinary bladder urothelial carcinoma cell by the ethanol extract of pomegranate fruit through cell cycle arrest and apoptosis.

Lee STLu MHChien LHWu TF1, Huang LCLiao GI.


Pomegranate fruit extract treatment might inhibit urinary bladder urothelial carcinoma cell proliferation.

BMC Complement Altern Med. 2016 Mar 9;16:96. doi: 10.1186/s12906-016-1071-7.

Clarification of the molecular pathway of Taiwan local pomegranate fruit juice underlying the inhibition of urinary bladder urothelial carcinoma cell by proteomics strategy.

Wu TF1, Hsu LT2, Tsang BX2, Huang LC2, Shih WY2, Chen LY2.



Paeonia suffruticosa bark may provide an alternative therapeutic strategy for the intravesical therapy of superficial bladder cancer.

Evid Based Complement Alternat Med. 2013;2013:207279. doi: 10.1155/2013/207279. Epub 2013 Oct 24.

Cortex Moutan Induces Bladder Cancer Cell Death via Apoptosis and Retards Tumor Growth in Mouse Bladders.

Lin MY1, Lee YRChiang SYLi YZChen YSHsu CDLiu YW.


Extracts from Artemisia herba-alba, Ruta chalpensis L. and Peganum harmala L. plants demonstrate a remarkable potential as a valuable source of antioxidants, exhibiting original and interesting anti-inflammatory and anticancer capacities in bladder cancer.

Food Chem Toxicol. 2013 May;55:202-8. doi: 10.1016/j.fct.2013.01.004. Epub 2013 Jan 16.

Composition and anti-oxidant, anti-cancer and anti-inflammatory activities of Artemisia herba-alba, Ruta chalpensis L. and Peganum harmala L.

Khlifi D1, Sghaier RMAmouri SLaouini DHamdi MBouajila J.



Justicia procumbens compounds could be a potential novel alternative to bladder cancer therapy.

J Ethnopharmacol. 2012 Nov 21;144(2):284-92. doi: 10.1016/j.jep.2012.09.010. Epub 2012 Sep 15.

JR6, a new compound isolated from Justicia procumbens, induces apoptosis in human bladder cancer EJ cells through caspase-dependent pathway.

He XL1, Zhang PDong XZYang MHChen SLBi MG.


Leaf Extracts of Calocedrus formosana may be an effective antibladder cancer agent.

Evid Based Complement Alternat Med. 2011;2011:380923. doi: 10.1155/2011/380923. Epub 2011 Jun 12.

Leaf Extracts of Calocedrus formosana (Florin) Induce G2/M Cell Cycle Arrest and Apoptosis in Human Bladder Cancer Cells.

Yuan SY1, Lin CCHsu SLCheng YWWu JHCheng CLYang CR.


In this study, Rhodiola rosea extract and one of its bioactive components, salidroside, inhibited the growth of bladder cancer cell lines.

Mol Carcinog. 2012 Mar;51(3):257-67. doi: 10.1002/mc.20780. Epub 2011 Apr 22.

Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy.

Liu Z1, Li XSimoneau ARJafari MZi X.



Sclerotia extract of Polyporus umbellatus and polyporus polysaccharide may be effective in inhibiting bladder carcinogenesis.


Am J Chin Med. 2011;39(1):135-44.

Inhibition of urinary bladder carcinogenesis by aqueous extract of sclerotia of Polyporus umbellatus fries and polyporus polysaccharide.

Zhang G1, Zeng XLi CLi JHuang YHan LWei JAHuang H.



Meriandra bengalensis showed potent cytotoxic effect against bladder cancer cell lines.

Pharmazie. 2009 Sep;64(9):613-5.

Antimicrobial and cytotoxic abietane diterpenoids from the roots of Meriandera benghalensis (Roxb.) Benth.

Mothana RA1, Jansen RGruenert RBednarski PJLindequist U.



Shi-Liu-Wei-Liu-Qi-Yin reduced tumor growth, caused cell-cycle arrest and apoptosis in human bladder carcinoma.

Evid Based Complement Alternat Med. 2011;2011:nep016. doi: 10.1093/ecam/nep016. Epub 2011 Jan 3.

Aqueous Extract of Shi-Liu-Wei-Liu-Qi-Yin Induces G2/M Phase Arrest and Apoptosis in Human Bladder Carcinoma Cells via Fas and Mitochondrial Pathway.

Ou TT1, Wang CJHung GUWu CHLee HJ.


Kava plant extract may be a good prevention and treatment of bladder cancer.     


Cancer Prev Res (Phila). 2008 Nov;1(6):439-51. doi: 10.1158/1940-6207.CAPR-08-0165.

Effects of the kava chalcone flavokawain A differ in bladder cancer cells with wild-type versus mutant p53.

Tang Y1, Simoneau ARXie JShahandeh BZi X.



Magnolia officinalis exhibits potential chemopreventive activity against urinary bladder tumors.


Phytother Res. 2009 Jan;23(1):20-7. doi: 10.1002/ptr.2413.

Inhibitory effects of the aqueous extract of Magnolia officinalis on the responses of human urinary bladder cancer 5637 cells in vitro and mouse urinary bladder tumors induced by N-Butyl-N-(4-hydroxybutyl) nitrosamine in vivo.

Lee SJ1, Cho YHPark KKim EJKang BSJung KHKim CHKim WJMoon SK.



Alcohol extract from seeds of Livistona chinensis could selectively inhibit the proliferation of bladder cancer cells.


Zhong Yao Cai. 2008 May;31(5):718-22.

[Screening of anti-tumor parts from the seeds of Livistona chinensis and its anti-angiogenesis effect].

[Article in Chinese]

Wang H1, Li ADong XPXu XY.



Components of cranberries may be effective in preventing urinary bladder carcinogenesis.

Oncol Rep. 2008 Jun;19(6):1565-70.

Effect of cranberry juice concentrate on chemically-induced urinary bladder cancers.

Prasain JK1, Jones KMoore RBarnes SLeahy MRoderick RJuliana MMGrubbs CJ.



Broccoli sprout extract is a highly promising substance for bladder cancer prevention.


Cancer Res. 2008 Mar 1;68(5):1593-600. doi: 10.1158/0008-5472.CAN-07-5009. Epub 2008 Feb 29.

Inhibition of urinary bladder carcinogenesis by broccoli sprouts.

Munday R1, Mhawech-Fauceglia PMunday CMPaonessa JDTang LMunday JSLister CWilson PFahey JWDavis WZhang Y.


Magnolia officinalis shows anti-cancer activity in human urinary bladder cells.

Oncol Rep. 2007 Sep;18(3):729-36.

Aqueous extract of Magnolia officinalis mediates proliferative capacity, p21WAF1 expression and TNF-alpha-induced NF-kappaB activity in human urinary bladder cancer 5637 cells; involvement of p38 MAP kinase.

Lee SJ1, Kim HMCho YHPark KKim EJJung KHKim CHKim WJMoon SK.


Serenoa Repens shows an antiproliferative effect which is triggered by induction of apoptosis.

Anticancer Res. 2007 Mar-Apr;27(2):873-81.

Evaluation of cell death caused by an ethanolic extract of Serenoae repentis fructus (Prostasan) on human carcinoma cell lines.

Hostanska K1, Suter AMelzer JSaller R.


Broccoli Sprout ITC is a promising agent for prevention of bladder cancer.

J Agric Food Chem. 2006 Dec 13;54(25):9370-6.

Induction of GST and NQO1 in cultured bladder cells and in the urinary bladders of rats by an extract of broccoli (Brassica oleracea italica) sprouts.

Zhang Y1, Munday RJobson HEMunday CMLister CWilson PFahey JWMhawech-Fauceglia P.


Antrodia Camphorata Extract can be rather effective and beneficial in suppression of bladder cancer cells.


J Ethnopharmacol. 2007 Jan 3;109(1):93-103. Epub 2006 Jul 11.

Antrodia camphorata extract induces replicative senescence in superficial TCC, and inhibits the absolute migration capability in invasive bladder carcinoma cells.

Peng CC1, Chen KCPeng RYChyau CCSu CHHsieh-Li HM.



Viscum Album Extract proteins were able to block the growth of bladder carcinoma cells.


Anticancer Res. 2006 Jul-Aug;26(4B):3049-55.

Antiproliferative effects of mistletoe (Viscum album L.) extract in urinary bladder carcinoma cell lines.

Urech K1, Buessing AThalmann GSchaefermeyer HHeusser P.


Standardized mistletoe extract could be a potential adjuvant therapy for superficial bladder cancer.

Anticancer Res. 2005 Nov-Dec;25(6C):4733-6.

Adjuvant intravesical treatment with a standardized mistletoe extract to prevent recurrence of superficial urinary bladder cancer.

Elsässer-Beile U1, Leiber CWetterauer UBühler PWolf PLucht MMengs U.


Lipophilic extract of Hypericum perforatum holds the promise of being an interesting, new, anti-proliferative agent against bladder cancer.

Planta Med. 2005 Nov;71(11):1030-5.

The lipophilic extract of Hypericum perforatum exerts significant cytotoxic activity against T24 and NBT-II urinary bladder tumor cells.

Skalkos D1, Stavropoulos NETsimaris IGioti EStalikas CDNseyo UOIoachim EAgnantis NJ.



Flavokawain A. may have a dual efficacy in induction of apoptosis preferentially in bladder tumors.

Cancer Res. 2005 Apr 15;65(8):3479-86.

Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice.

Zi X1, Simoneau AR.



Water extract of Polyporus could provide significant protection against the promotion of bladder tumors.


Biol Pharm Bull. 2000 Nov;23(11):1298-302.

Antitumor promoting effect of an active component of Polyporus, ergosterol and related compounds on rat urinary bladder carcinogenesis in a short-term test with concanavalin A.

Yazawa Y1, Yokota MSugiyama K.



Green tea may inhibit bladder tumor growth.


Int J Urol. 1999 Feb;6(2):93-9.

Inhibition of urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl)-nitrosamine in rats by green tea.

Sato D1.



This study shows a therapeutic usage of green tea polyphenols against bladder.

Biomed Res. 2009 Aug;30(4):207-15.

Induction of apoptosis in human bladder cancer cells by green tea catechins.

Philips BJ1, Coyle CHMorrisroe SNChancellor MBYoshimura N.


Ascorbic acid, lysine, proline, arginine, and green tea extract nutrient mixture is an excellent candidate for therapeutic use in the treatment of bladder cancer.


Int J Urol. 2006 Apr;13(4):415-9.

Antitumor effect of ascorbic acid, lysine, proline, arginine, and green tea extract on bladder cancer cell line T-24.

Roomi MW1, Ivanov VKalinovsky TNiedzwiecki ARath M.

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