Prostate Cancer Research

in the peer-reviewed medical literature

 

High dose vitamin C intravenously, helps to induce cell death in prostate cancer cells.

 

 

Anticancer Drugs. 2012 Apr;23(4):437-44. doi: 10.1097/CAD.0b013e32834fd01f.

Pharmacological ascorbate induces cytotoxicity in prostate cancer cells through ATP depletion and induction of autophagy.

Chen P1, Yu J, Chalmers B, Drisko J, Yang J, Li B, Chen Q.

 

Cilantro (Coriandrum sativum) extract has been shown to hinder the growth of prostate cancer.

 

J Cell Biochem.  Elmas L, Secme M, Mammadov R, Fahrioglu U, Dodurga Y. The determination of the potential anticancer effects of Coriandrum sativum in PC-3 and LNCaP prostate cancer cell lines. 2019 Mar;120(3):3506-3513. doi: 10.1002/jcb.27625. Epub 2018 Nov 11. PubMed PMID: 30417420.

 

Extract from pomegranate leaves promotes Prostate Cancer cell death and impairs the cell’s functions.

 

Sichuan Da Xue Xue Bao Yi Xue Ban.  Deng YL, Li YL, Zheng TT, Hu MX, Ye TH, Xie YM, Yin WY. [The Extract from Punica Granatum (Pomegranate) Leaves Promotes Apoptosis and Impairs Metastasis in Prostate Cancer Cells]. 2018 Jan;49(1):8-12. PubMed PMID: 29737081.

 

An extract from the flowering plant Cheilocostus speciosus has been shown to reduce the ability of prostate cancer cells to multiply and spread and to induce cell death.

 

Am J Transl Res.   Elkady AI. Targeting prostate cancer cell proliferation, stemness and metastatic potential using Costus speciosus derived phytochemicals. 2019;11(4):2550-2569. eCollection 2019. PubMed PMID: 31105862; PubMed Central PMCID: PMC6511805.

 

The plant Androsace umbellata used in traditional herbal medicine contains a compound Afrocyclamin A which induces the death of prostate cancer cells.

 

Phytomedicine.  Sachan R, Kundu A, Jeon Y, Choi WS, Yoon K, Kim IS, Kwak JH, Kim HS. Afrocyclamin A, a triterpene saponin, induces apoptosis and autophagic cell death via the PI3K/Akt/mTOR pathway in human prostate cancer cells. 2018 Dec 1;51:139-150. doi: 10.1016/j.phymed.2018.10.012. Epub 2018 Oct 10. PubMed PMID: 30466611.

 

Camellia sinensis, the plant black and green tea are made from, contains a compound which induces the death of prostate cancer cells.

 

Int J Biol Macromol.  Yang K, Gao ZY, Li TQ, Song W, Xiao W, Zheng J, Chen H, Chen GH, Zou HY. Anti-tumor activity and the mechanism of a green tea (Camellia sinensis) polysaccharide on prostate cancer. 2019 Feb 1;122:95-103. doi: 10.1016/j.ijbiomac.2018.10.101. Epub 2018 Oct 17. PubMed PMID: 30342140.


Curcumin, garlic, and Vernonia amygdalina show potential to prevent/treat prostate cancer.

Nutrients.  Yedjou CG, Mbemi AT, Noubissi F, Tchounwou SS, Tsabang N, Payton M, Miele L, Tchounwou PB. Prostate Cancer Disparity, Chemoprevention, and Treatment by Specific Medicinal Plants. 2019 Feb 4;11(2). doi: 10.3390/nu11020336. Review. PubMed PMID: 30720759; PubMed Central PMCID: PMC6412894.

Nummularic acid a compound from the plant Fraxinus xanthoxyloides suppresses the growth of prostate cancer cells.

Mol Carcinog.  Younis T, Khan MI, Khan MR, Rasul A, Majid M, Adhami VM, Mukhtar H. Nummularic acid, a triterpenoid, from the medicinal plant Fraxinus xanthoxyloides, induces energy crisis to suppress growth of prostate cancer cells. 2018 Oct;57(10):1267-1277. doi: 10.1002/mc.22841. Epub 2018 Jun 5. PubMed PMID: 29802724.

When used in conjunction with Paclitaxel a chemical isolated from the tree Pacific Yew the extracts from the Turkish plants: Alkanna tinctoria, Phlomis leucophracta, and Rubia davisiana where shown do reduce proliferation of prostate cancer cells and to induce the death of the cells.

 

Gene.  Doğan Şiğva ZÖ, Balci Okcanoğlu T, Biray Avci Ç, Yilmaz Süslüer S, Kayabaşi Ç, Turna B, Dodurga Y, Nazli O, Gündüz C. Investigation of the synergistic effects of paclitaxel and herbal substances and endemic plant extracts on cell cycle and apoptosis signal pathways in prostate cancer cell lines. 2019 Mar 1;687:261-271. doi: 10.1016/j.gene.2018.11.049. Epub 2018 Nov 17. PubMed PMID: 30453074.

 

The organic compound Juglone, which is derived from multiple plants including  black walnut (Juglans nigraI) and commonly used in the food industry as a dye; has been shown to reduce the invasiveness of prostate cancer cells.

 

Oncol Lett.  Fang F, Chen S, Ma J, Cui J, Li Q, Meng G, Wang L. Juglone suppresses epithelial-mesenchymal transition in prostate cancer cells via the protein kinase B/glycogen synthase kinase-3β/Snail signaling pathway. 2018 Aug;16(2):2579-2584. doi: 10.3892/ol.2018.8885. Epub 2018 Jun 4. PubMed PMID: 30013652; PubMed Central PMCID: PMC6036567.

 

Several herbal medicines used by Mayans have been shown to possess anti-tumor effects.

 

Pharmaceuticals (Basel).  Fort RS, Trinidad Barnech JM, Dourron J, Colazzo M, Aguirre-Crespo FJ, Duhagon MA, Álvarez G. Isolation and Structural Characterization of Bioactive Molecules on Prostate Cancer from Mayan Traditional Medicinal Plants. 2018 Aug 14;11(3). doi: 10.3390/ph11030078. PubMed PMID: 30110911; PubMed Central PMCID: PMC6160984.

 

Excelsanone an ethyl acetate extract of Erythrina excelsa stem bark has been shown to be toxic to prostate cancer cells.

 

Nat Prod Res.  Gbaweng AJY, Daïrou H, Zingué S, Emmanuel T, Tchinda AT, Frédérich M, Mbafor JT.Excelsanone, a new isoflavonoid from Erythrina excelsa (Fabaceae), with in vitro antioxidant and in vitro cytotoxic effects on prostate cancer cells lines. 2018 Nov 8;:1-9. doi: 10.1080/14786419.2018.1495639. [Epub ahead of print] PubMed PMID: 30406690.

 

Alginate oligosaccharide a compound from the cell walls of algae slows the growth of prostate cancer.

 

Cell Death Dis.  Han Y, Zhang L, Yu X, Wang S, Xu C, Yin H, Wang S. Alginate oligosaccharide attenuates α2,6-sialylation modification to inhibit prostate cancer cell growth via the Hippo/YAP pathway. 2019 May 10;10(5):374. doi: 10.1038/s41419-019-1560-y. PubMed PMID: 31076566; PubMed Central PMCID: PMC6510775.

 

Rosmarinic Acid, a Component of Rosemary Tea can stop the function of and kill prostate cancer cells.

 

Nutrients.  Jang YG, Hwang KA, Choi KC. Rosmarinic Acid, a Component of Rosemary Tea, Induced the Cell Cycle Arrest and Apoptosis through Modulation of HDAC2 Expression in Prostate Cancer Cell Lines. 2018 Nov 16;10(11). doi: 10.3390/nu10111784. PubMed PMID: 30453545.

 

Peperomin E a substance in plants from the genus Peperomia is shown to inhibit the spread of prostate cancer by stopping the cell cycle and killing prostate cancer cells.

 

Molecules.  Li Y, Pan J, Gou M. The Anti-Proliferation, Cycle Arrest and Apoptotic Inducing Activity of Peperomin E on Prostate Cancer PC-3 Cell Line. 2019 Apr 15;24(8). doi: 10.3390/molecules24081472. PubMed PMID: 30991627; PubMed Central PMCID: PMC6514592.

 

It is shown that supplementing Vitamin D in addition to other cancer treatments can be a beneficial choice.

 

Int J Vitam Nutr Res.  Petrou S, Mamais I, Lavranos G, P Tzanetakou I, Chrysostomou S. Effect of Vitamin D Supplementation in Prostate Cancer: A Systematic Review of Randomized Control Trials. 2018 Feb;88(1-2):100-112. doi: 10.1024/0300-9831/a000494. Epub 2019 Apr 30. PubMed PMID: 31038028.

 

Plants such as Paederia foetida can induce a response from the immune system to oppose the growth of prostate cancer cells.

 

Food Chem Toxicol.   Pradhan N, Parbin S, Kausar C, Kar S, Mawatwal S, Das L, Deb M, Sengupta D, Dhiman R, Patra SK. Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells. 2019 Aug;130:161-173. doi: 10.1016/j.fct.2019.05.016. Epub 2019 May 18. PubMed PMID: 31112703.

 

Oncotarget. 2017 Feb 16. doi: 10.18632/oncotarget.15353. [Epub ahead of print]

Artesunate suppresses the viability and mobility of prostate cancer cells through UCA1, the sponge of miR-184.

Zhou Y1, Wang X2, Zhang J1, He A1, Wang YL1, Han K1, Su Y1, Yin J1, Lv X3, Hu H1.

 

 

Regular consumption of Camellia Sinensis for a long period may prevent men from developing prostate cancer or at least delay its progression.

 

Evid Based Complement Alternat Med. 2017;2017:1691568. doi: 10.1155/2017/1691568. Epub 2017 Jan 4.

Protective Effect of Green Tea (Camellia sinensis (L.) Kuntze) against Prostate Cancer: From In Vitro Data to Algerian Patients.

Lassed S1, Deus CM2, Djebbari R3, Zama D4, Oliveira PJ2, Rizvanov AA5, Dahdouh A6, Benayache F4, Benayache S4.

 

 

Taraxacum (Dandelion) may inhibit growth of both breast and prostate cancers.

 

Int J Oncol. 2008 May;32(5):1085-90.

Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells.

Sigstedt SC1, Hooten CJCallewaert MCJenkins ARRomero AEPullin MJKornienko ALowrey TKSlambrouck SVSteelant WF.

 

 

Ganoderma lucidum exerts its effect on cancer cells by multiple mechanisms and may have potential therapeutic use for the prevention and treatment of prostate cancer.

 

Int J Oncol. 2004 May;24(5):1093-9.

Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3.

Jiang J1, Slivova VValachovicova THarvey KSliva D.

 

Cayenne Pepper contributes to antiproliferation in prostate cancer cells

Oncotarget. 2016 Jan 12;7(2):1569-83. doi: 10.18632/oncotarget.6415.

The pepper's natural ingredient capsaicin induces autophagy blockage in prostate cancer cells.

Ramos-Torres Á1, Bort A1, Morell C1, Rodríguez-Henche N1, Díaz-Laviada I1.

 

Artemisia Annua capsules combined with short-term bicalitumide treatment resulted in considerable regression of advanced metastasized prostate carcinoma

 

Phytomedicine. 2015 Dec 15;22(14):1223-31. doi: 10.1016/j.phymed.2015.11.001. Epub 2015 Nov 10.

Activity of Artemisia annua and artemisinin derivatives, in prostate carcinoma.

Michaelsen FW1, Saeed ME2, Schwarzkopf J3, Efferth T4.

 

 

This study identified two new curcumin conjugate compounds with more potent activity than curcumin against breast and prostate cancers.  Curcumin mimics show selective activity against breast and prostate cancer cell lines.

Bioorg Med Chem Lett. 2016 Sep 1;26(17):4223-32. doi: 10.1016/j.bmcl.2016.07.053. Epub 2016 Jul 25.

Synthesis and biological evaluation of some novel triazole hybrids of curcumin mimics and their selective anticancer activity against breast and prostate cancer cell lines.

Mandalapu D1, Saini KS2, Gupta S3, Sharma V2, Yaseen Malik M4, Chaturvedi S4, Bala V3, Hamidullah2, Thakur S5, Maikhuri JP2, Wahajuddin M4, Konwar R2, Gupta G2, Sharma VL6.

DMSO and sodium bicarbonate intravenous, helps relieve pain in patients with metastatic prostate cancer.

 

J Pain Palliat Care Pharmacother. 2011;25(4):350-5. doi: 10.3109/15360288.2011.606294. Epub 2011 Sep 21.

Dimethyl sulfoxide-sodium bicarbonate infusion for palliative care and pain relief in patients with metastatic prostate cancer.

Hoang BX1, Le BT, Tran HD, Hoang C, Tran HQ, Tran DM, Pham CQ, Pham TD, Ha TV, Bui NT, Shaw DG.

N-Acetyl Cysteine may suppress the growth of prostate tumors.

 

J Med Assoc Thai. 2012 Dec;95 Suppl 12:S56-62.

Antimetastatic potential of N-acetylcysteine on human prostate cancer cells.

Supabphol A1, Supabphol R.

Soy been could be a natural supplement in an alternative for prostate, breast, and blood cancer therapy.

J Food Sci Technol. 2017 Jan;54(1):38-44. doi: 10.1007/s13197-016-2426-2. Epub 2017 Jan 13.

Soybean peptide fractions inhibit human blood, breast and prostate cancer cell proliferation.

Rayaprolu SJ1, Hettiarachchy NS1, Horax R1, Phillips GK2, Mahendran M3, Chen P4.

 

Andrographolide suppresses prostate cancer cell growth

Genes Cancer. 2010 Aug;1(8):868-76. doi: 10.1177/1947601910383416.

Andrographolide, an herbal medicine, inhibits interleukin-6 expression and suppresses prostate cancer cell growth.

Chun JY1, Tummala RNadiminty NLou WLiu CYang JEvans CPZhou QGao AC.

 

Gallic acid shows inhibition of MMP-2 and -9 of PC-3 human prostate cancer cells.

 

Oncol Rep. 2011 Jul;26(1):177-84. doi: 10.3892/or.2011.1264. Epub 2011 Apr 15.

Gallic acid suppresses the migration and invasion of PC-3 human prostate cancer cells via inhibition of matrix metalloproteinase-2 and -9 signaling pathways.

Liu KC1, Huang ACWu PPLin HYChueh FSYang JSLu CCChiang JHMeng MChung JG.

 

Licorice Root might inhibit the metastatic and invasive capacity of malignant prostate cancer cells.

 

Br J Nutr. 2010 Nov;104(9):1272-82. doi: 10.1017/S0007114510002114. Epub 2010 May 21.

Hexane-ethanol extract of Glycyrrhiza uralensis containing licoricidin inhibits the metastatic capacity of DU145 human prostate cancer cells.

Park SY1, Lim SSKim JKKang IJKim JSLee CKim JPark JH.

 

Red Clover extract exerts the anticarcinogenic effect on prostate cancer.

 

Nutr Cancer. 2014;66(4):656-61. doi: 10.1080/01635581.2014.894098. Epub 2014 Mar 25.

Formononetin induces apoptosis in PC-3 prostate cancer cells through enhancing the Bax/Bcl-2 ratios and regulating the p38/Akt pathway.

Zhang X1, Bi LYe YChen J.

 

 

Barberry extract has a high therapeutic potential in targeting prostate cancer and its cancer stem cells

 

PLoS One. 2014 Nov 7;9(11):e112453. doi: 10.1371/journal.pone.0112453. eCollection 2014.

Berberis libanotica Ehrenb extract shows anti-neoplastic effects on prostate cancer stem/progenitor cells.

El-Merahbi R1, Liu YN2, Eid A1, Daoud G1, Hosry L3, Monzer A1, Mouhieddine TH1, Hamade A4, Najjar F5, Abou-Kheir W1.

 

 

Red Sage might contribute to the anticancer actions such as induction of apoptosis and inhibition of proliferation of prostate cancer cells.

Chin J Integr Med. 2017 Mar 23. doi: 10.1007/s11655-017-2801-5. [Epub ahead of print]

Inhibition of proliferation of prostate cancer cell line DU-145 in vitro and in vivo using Salvia miltiorrhiza Bunge.

Bae WJ1,2, Choi JB1, Kim KS1, Syn Ha U1, Hong SH1, Lee JY1, Hwang TK1, Hwang SY3, Wang ZP4, Kim SW5,6.

 

 

Anthocyanins from black soybean inhibit the progression of prostate cancer

 

Yonsei Med J. 2015 Jan;56(1):16-23. doi: 10.3349/ymj.2015.56.1.16.

Anthocyanin induces apoptosis of DU-145 cells in vitro and inhibits xenograft growth of prostate cancer.

Ha US1, Bae WJ2, Kim SJ1, Yoon BI1, Hong SH1, Lee JY1, Hwang TK1, Hwang SY3, Wang Z4, Kim SW5.

 

Honokiol, which is used in traditional oriental medicine for the treatment of various ailments, may be an attractive agent for treatment and/or prevention of human prostate cancers

 

Clin Cancer Res. 2008 Feb 15;14(4):1248-57. doi: 10.1158/1078-0432.CCR-07-1926.

Honokiol, a constituent of oriental medicinal herb magnolia officinalis, inhibits growth of PC-3 xenografts in vivo in association with apoptosis induction.

Hahm ER1, Arlotti JAMarynowski SWSingh SV.

Dietary modulation of miRNA expression may contribute to the cancer-protective effects of dietary components.

 

Pharm Res. Diet, microRNAs and prostate cancer. Review article. Saini S, et al. 2010. https://www.ncbi.nlm.nih.gov/m/pubmed/20221895/

 

 

Clinical trials of GTP, especially in prostate cancer patients have yielded encouraging results. This article briefly reviews properties of GTP, especially EGCG with reference to multitargeted therapy of cancer.

 

Cancer Lett.  Multitargeted therapy of cancer by green tea polyphenols. Review article. Khan N, et al. 2008. https://www.ncbi.nlm.nih.gov/m/pubmed/18501505/

Diosmetin, a plant flavonoid, has been shown to exert promising effects on prostate cancer cells as an anti‑proliferative and anticancer agent.

 

Int J Oncol. 2018 May 16. doi: 10.3892/ijo.2018.4407. [Epub ahead of print]

Diosmetin suppresses human prostate cancer cell proliferation through the induction of apoptosis and cell cycle arrest.

Oak CKhalifa AOIsali IBhaskaran NWalker EShukla S.

Extract from the South Asian plant Psoralea corylifolia induces the death of prostate cancer cells.

 

Environ Toxicol.  Lin CH, Funayama S, Peng SF, Kuo CL, Chung JG. The ethanol extraction of prepared Psoralea corylifolia induces apoptosis and autophagy and alteres genes expression assayed by cDNA microarray in human prostate cancer PC-3 cells. 2018 Jul;33(7):770-788. doi: 10.1002/tox.22564. Epub 2018 Apr 18. PubMed PMID: 29667321.

UCA1 level was reduced significantly after being exposed to ART.

None of the 700+ studies listed on this site can substitute for consulting a licensed naturopathic physician.  And none can be expected to function as stand-alone, at-home treatment.